Date:5/13/2010

cting low, medium, and high doses of dibenzo[a,l]pyrene, a powerful carcinogen in tobacco, into the mouths of 104 mice. The researchers examined 24 of the mice for mutagenesis and 80 for carcinogenesis. After 38 weeks, all of the mice in the high-dose mutagenesis group developed excessive numbers of mutations in their oral tissue, and within one year, 31% of the high-dose carcinogenesis group displayed large tumors in their mouths.

"As a result of this study," said Dr. Guttenplan, "we now have a model that is significantly better than past models which relied on synthetic carcinogens. "We plan to use this new model in future studies to examine potential agents for cancer prevention."

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Contact: Christopher James christopher.james@nyu.edu 212-998-6876 New York University Source:Eurekalert

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