Navigation Links
NYU College of Dentistry, Penn State develop new model for investigating tobacco/oral cancer link
Date:5/13/2010

Although tobacco use is widely understood to be one of the leading causes of oral cancer, research on the prevention of tobacco-related oral cancer in experimental animals has traditionally been limited to examining the impact of synthetic carcinogens manufactured especially for cancer research, rather than on observing the effects of carcinogens that occur in tobacco smoke.

Now, a recently completed study conducted collaboratively by Dr. Joseph Guttenplan, a Professor of Basic Science & Craniofacial Biology at the NYU College of Dentistry, and Dr. Karam El-Bayoumy, a Professor of Biochemistry and Molecular Biology at Penn State University College of Medicine and Associate Director of Basic Research at the Penn State Cancer Institute, has shown that a powerful carcinogen in tobacco smoke can be used for oral cancer research in experimental animals, thus providing a new, more relevant research model with which to understand the initiation, progression, and, ultimately, the prevention of oral cancer. The two-year study was sponsored by the National Institute of Dental and Craniofacial Research, part of the NIH.

In a presentation on April 19 at the 2010 annual meeting of the American Association for Cancer Research (AACR) in Washington, DC, Dr. Guttenplan said the findings could ultimately facilitate research aimed at identifying new approaches to oral cancer prevention.

Oral cancer is a devastating disease that can severely and permanently compromise one's ability to eat, drink, talk, and even kiss. In the United States, about 100 new cases of oral cancer occur each day, and approximately 7,000 people die annually from the disease. Worldwide, over 640,000 new cases of oral cancer occur annually. In addition to tobacco use, alcohol use and exposure to the HPV-16 virus (human papilloma virus version 16) are the leading causes of oral cancer.

The study described in Dr. Guttenplan's presentation examined the impact of injecting low, medium, and high doses of dibenzo[a,l]pyrene, a powerful carcinogen in tobacco, into the mouths of 104 mice. The researchers examined 24 of the mice for mutagenesis and 80 for carcinogenesis. After 38 weeks, all of the mice in the high-dose mutagenesis group developed excessive numbers of mutations in their oral tissue, and within one year, 31% of the high-dose carcinogenesis group displayed large tumors in their mouths.

"As a result of this study," said Dr. Guttenplan, "we now have a model that is significantly better than past models which relied on synthetic carcinogens. "We plan to use this new model in future studies to examine potential agents for cancer prevention."


'/>"/>

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Related medicine news :

1. High School and College Students Take No-Tanning Pledge to Stay out of Tanning Beds for Proms and Spring Break
2. Ashworth College Instructor Dr. Nicole Detling Miller Appears on Colbert Report
3. Eukanuba Partners With Cat Fancy(R) to Launch Cat College
4. ChildRC.com Features “Acclimating To College Life In A Wheelchair”
5. Researchers at Meharry Medical College Find Green Tea Extract Showing Promise for Treatment of Uterine Fibroids
6. New Hampshire Community Colleges Choose Rapid Insight for Data Reporting Needs
7. Oversized College Football Players May Face Heart Risks
8. Meharry Medical College Officer Will Head the National Dental Association
9. Recovery Act dollars are stimulating research at the Medical College of Georgia
10. Exergen TemporalScanner Sponsors Game Time Temperature for NFL and College Bowl Games
11. College football linemen take one for the team in terms of health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... , ... December 08, 2016 , ... ... Center has been recognized for adherence to the highest standards of trauma, ... accreditation organizations, announced the center's president and CEO, Dr. Daniel Messina. , Among ...
(Date:12/8/2016)... ... , ... Vida Health, the digital health platform that pairs individuals ... Ventures . Other investors include Nokia Growth Partners (NGP) and returning investor Aspect Ventures. ... who are managing chronic conditions or simply want to improve their health. ...
(Date:12/8/2016)... ... , ... Coppin Insurance Agency, an insurance and financial planning firm based in ... area, is embarking on a charity drive with the goal of providing support and ... Food Bank of Southwest Florida works to provide fresh and nutritious food free of ...
(Date:12/7/2016)... ... December 07, 2016 , ... Students ... have the unique opportunity to get hands-on experience in an emergency medical simulation, ... immersive experience to gain invaluable, real-life medical skills that are critical success in ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... of Smart Device Remote Control through a new partnership with Splashtop Inc. This ... strengthens its mobile solutions to help businesses maximize their uptime and productivity. , ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... FRANCISCO, Calif. , Dec. 8, 2016 /PRNewswire/ ... technology to develop novel antiviral therapeutics, today announced ... as chief executive officer and a member of ... an incredibly experienced executive with a deep background ... Stephen Quake, D.Phil., founder of Agenovir, co-president of ...
(Date:12/8/2016)...  Haemonetics Corporation (NYSE: HAE ) has released ... innovative software suite designed to help customers drive efficiency in ... NextGen DMS 4 improves core features and introduces innovations aligned ... of plasma collected, enhancing quality and regulatory compliance and leveraging ... ...
(Date:12/8/2016)... 8, 2016 Henry Schein, Inc. (Nasdaq: ... and services to office-based dental, animal health and medical practitioners, ... in Marrodent, one of Poland,s largest ... This transaction was announced on August 30, 2016. ... Poland since 2014, and Marrodent marks the Company,s ...
Breaking Medicine Technology: