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NYP/Weill Cornell physician-scientists present latest cancer findings at ASCO meeting
Date:5/31/2008

ood vessel growth (angiogenesis) to tumors is safe and highly effective for the treatment of early-stage non-small cell lung cancer. Pazopanib works by blocking the action of vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which both work by growing bloods vessels that supply nutrition to tumors. Prior to surgery to remove their tumors, 87 percent of the 26 subjects tested had a significant reduction in tumor growth.

Palonosetron (PALO) for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose melphalan prior to stem cell transplant (SCT). [Abstract number: 9617; Poster number 47B]

Time: Saturday, May 31, 2:00 p.m. 6:00 p.m
Authors: S. Giralt, K. Mangan, R. Maziarz, J. S. Bubalo, R. Beveridge, D. D. Hurd, F. Mendoza, E. B. Rubenstein, T. J. DeGroot, M. W. Schuster

Principal investigator Dr. Michael Schuster's multicenter trial group will present findings from a Phase II clinical trial showing that a new drug called Palonosetron (PALO) is safe and effective at reducing vomiting and nausea -- common side effects of chemotherapy -- in multiple myeloma patients undergoing multi-day high-dose chemotherapy and autologous stem cell transplantation. All of the subjects studied were taking a common chemotherapy agent called melphalan at the time of the study. The researchers found that those who were on multiple daily doses of PALO reported fewer incidences of vomiting and nausea.

LE-SN38 for metastatic colorectal cancer after progression on oxaliplatin: Results of CALGB 80402. [Abstract number: 4109; Poster number: 16A]

Time: Monday, June 2, 8:00 a.m. 12:00 p.m.
Authors: A. J. Ocean, D. Niedzwiecki, J. N. Atkins, B. Parker, B. H. O'Neil, J. W. Lee, S. Wadler, R. M. Goldberg

Dr. Allyson Ocean will present data showing that LESN-38, the active molecule of the chemotherapy drug ir
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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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