Navigation Links
NUS researchers make new discovery of protein as a promising target for treatment of ATC
Date:2/18/2014

Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer with a poor prognosis for which there is currently no effective treatment. Researchers from the National University of Singapore (NUS) have discovered for the first time that an epithelial basement membrane protein, called laminin-5 gamma-2 (LAMC2), has the potential to be an ideal target for the treatment of ATC.

Led by Professor H. Phillip Koeffler, Senior Principal Investigator, and Dr Manoj Garg, Research Fellow, at the Cancer Science Institute of Singapore (CSI Singapore) at NUS, the team is also the first to demonstrate that effect of LAMC2 on cell growth, cell cycle, migration and invasion in ATC cells. This novel study was published in the Journal of Clinical Endocrinology and Metabolism last month.

Thyroid cancer is the most common cancer of the endocrine system. ATC are undifferentiated tumours of the thyroid follicular epithelium. This type of cancer has a poor prognosis due to their extremely aggressive nature and resistance to treatment. Overall survival from diagnosis is typically six months or less. As such, new therapeutic targets are needed to improve the clinical care of these patients.

The effect of LAMC2 on ATC cells

In their study, the researchers found that LAMC2 is over-expressed in a large cohort of ATC patient samples. Analysis of RNA data of ATC cells showed that LAMC2 is likely to play a role in the formation of tumours. They discovered that silencing of LAMC2 in ATC cells reduced their cell growth, migration and invasion. In addition, silencing of this protein impaired the cell cycle of ATC cells by arresting them at the growth phase to DNA replication phase, or the G1 to S phase transition, of their cell cycle.

At the same time, the study found that LAMC2 enhanced activation of growth signals through a cell surface protein called epidermal growth factor receptor (EGFR) in ATC cells. EGFR plays an important
'/>"/>

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scripps researchers recommend mobile compression device to prevent DVT after joint surgery
2. No such thing as porn addiction, researchers say
3. LA BioMed researchers report on promising new therapy for devastating genetic disorder
4. NIH-funded researchers use antibody treatment to protect humanized mice from HIV
5. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
6. Researchers discover new hormone receptors to target when treating breast cancer
7. Kessler Foundation MS researchers study predictors of employment status
8. RI Hospital researchers identify components in C. diff that may lead to better treatment
9. Researchers create database to examine vast resources of health legacy foundations
10. UC Irvine stem cell researchers awarded $1.54 million in state funding
11. Researchers find novel approach for controlling deadly C. difficile infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... TherapySites, the leading website and ... its affiliation with the Illinois Association for Marriage ... TherapySites to continue to extend their online marketing solutions ... , “There has been a fundamental shift in the ... 3 billion Internet users, it is so important to ...
(Date:7/28/2014)... According to the Heartburn No More PDF review ... will help people get rid of acid reflux ... about heartburn and acid reflux. In addition, inside this book, ... risk factors for reflux disease. , Vkool informs in ... of symptoms of reflux disease naturally without medications. The book ...
(Date:7/28/2014)... New York, NY (PRWEB) July 28, 2014 ... completed the exit of its investment in Loftware, Inc., ... Partners of Boston. Shore Points was the lead investor ... which the Company has become the leading international provider ... applications. , “Loftware has been a great investment for ...
(Date:7/27/2014)... Hyaluronic Acid can hold 1,000 times ... to the power of Hyaluronic Serums. , "Hyaluronic acid ... of Sublime Beauty®. "But like collagen, it diminishes with ... improves skin moisture-retention and radiance." , Hyaluronic acid ... healthy and beautiful look. Key Ingredients in the serum ...
(Date:7/27/2014)... hepatitis E virus (HEV) transmission by blood components indicates ... HEV in their plasma. The findings, published in ... components (eg, red cells, platelets, and fresh frozen plasma) ... , The study retrospectively screened 225 000 individual ... 2012 and Sept, 2013 for HEV RNA. 79 donors ...
Breaking Medicine News(10 mins):Health News:TherapySites (Websites for Therapists) Partners with the Illinois Association for Marriage and Family Therapy 2Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 2Health News:Heartburn No More Pdf Review Exposes Jeff Martin's Guide For Treating Heartburn – Vkool.com 3Health News:Shore Points Capital Announces Sale of Portfolio Company Loftware 2Health News:Aging or Dry Skin Benefits from Hyaluronic Serum; Now 30% Off Sale at Sublime Beauty® 2Health News:The Lancet: 1 in 3000 blood donors in England infected with hepatitis E 2
... that the brain is always alert even if there is ... they are listening out for a sound. ,Pierre ... national research institute. He studied the brain activity of 11patients ... Imaging. // It showed that they were actually listening ...
... leg pain and very pale skin can all be early ... ,Thousand’s of children's lives will be saved ... for parents, which could speed diagnosis and treatment. ... their child having a headache, stiff neck, sensitivity to light ...
... Professor Stuart J. Connolly and his team from McMaster ... JAMA that a combination of Antiarrhythmic drugs such as ... found to reduce the painful shocks in ventricular arrhythmia ... high voltage shocks which are used to treat fatal ...
... is lot of relaxation in weight reduction programs. This however cannot ... is to listen to one’s inner voice and constantly work towards ... voice starts piping up as you lie on the couch. "Go ... those potato chips," it urges., ,The voice is that ...
... led to researchers warning British tourists to keep away from ... into Britain. Despite these warnings of a possible spread of ... Association of British Travel Agents had reported that the tourist ... be not afraid of bird flu threat. The tour promoters ...
... shown that tomato juice prevented emphysema in mice exposed to ... disease. // ,The lung protective effect was attributed ... to be the first to link tomato consumption to emphysema ... 'We can't simply accept that these results go beyond the ...
Cached Medicine News:Health News:New warning signs for child meningitis 2Health News:Being Active In Winter Despite That Inner Urge 2
(Date:7/25/2014)... , July 25, 2014  Smile Train and ... to showcase their Virtual Surgery Simulator among leading global ... will take place in Washington, D.C. ... Performing Arts. "Smile Train is honored ... the talented community of innovators in health and medicine ...
(Date:7/25/2014)... , July 25, 2014 GrowBLOX Sciences, Inc. (OTCQB: ... Memorandum of Understanding ("MOU") with LaurelCo, LLC, an ... acquisition of both cultivation and dispensary medical marijuana licenses in ... the MOU, GBLX will acquire a 20% equity interest in ... GrowBLOX TM growing chambers, as well as all technology ...
(Date:7/25/2014)... -- Solanbridge Group Inc (OTC: SLNX) is pleased to announce ... and the Letter of Intent issued on July 11, ... Agreement. Charles R. Shirley , Managing ... Mr. David Pecoraro and Buzznbrewz.com join SLNX,s ... sector and developed a tremendous network of contacts who ...
Breaking Medicine Technology:Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 2Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 3GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 2GrowBLOX Sciences, Inc. Partners with LaurelCo, LLC to Obtain Licenses to Cultivate and Dispense Medical Marijuana in Illinois 3Solanbridge Group Inc Announces Acquisition of Buzznbrewz.com 2
... May 19, 2011 Omeros Corporation ... it is advancing two of its product candidates ... meniscectomy and OMS302 for intra-ocular lens replacement surgery ... of these product candidates are added to standard ...
... (Nasdaq: ENMD ), a clinical-stage pharmaceutical company ... the presentation of clinical data for its Phase 2 ... data will be presented at the American Society of ... 3 - 7, 2011 in Chicago, Illinois. ...
Cached Medicine Technology:Omeros Announces Clinical Development Programs for OMS103HP and OMS302 2Omeros Announces Clinical Development Programs for OMS103HP and OMS302 3Omeros Announces Clinical Development Programs for OMS103HP and OMS302 4Omeros Announces Clinical Development Programs for OMS103HP and OMS302 5EntreMed ENMD-2076 Phase 2 Data to Be Presented at ASCO Annual Meeting 2EntreMed ENMD-2076 Phase 2 Data to Be Presented at ASCO Annual Meeting 3
Lightweight & portable, compact station. Accurate and speedy measurement, auto-shot function, AI measuring function, focusing indicator....
... Medennium is an innovative device used ... duct, and conserve the eye's natural ... a range of punctum sizes. Made ... SmartPLUG adjusts to the exact shape ...
Provides quick freezing and quick defrosting. Lightweight probe tips have high conductivity silver. Useful for Cataract, Retinal Detachment, Glaucoma and Intra-vitreal surgery. Includes either one ca...
Khosla Precision and Quality in Medical and Surgical Products....
Medicine Products: