Navigation Links
NUS researchers discover novel protein complex with potential to combat gastric cancer

A team of scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) discovered that a protein named IL23A is part of our stomach's defence against bacterial infection which leads to gastric cancer. This finding could potentially be used to combat the deadly disease.

The research group, led by Professor Yoshiaki Ito, Senior Principal Investigator at CSI Singapore, also showed that the production of IL23A by stomach cells requires the tumour suppressor gene, RUNX3, which is frequently silenced in gastric cancer. The novel study was first published online in the leading journal Cell Reports on 4 July 2014.

Every year, some 740,000 people die from gastric cancer globally. In Singapore, stomach cancer was the fourth leading cause of cancer death among men and fifth among women from 2008 to 2012. This highlights the urgent need to understand the causes of this deadly disease. It is now known that a major trigger for the development of gastric cancer is the infection of a bacterium, Helicobacter pylori. A drawn-out battle against this bacterium often causes persistent inflammation of the stomach, which is a dangerous cancer-causing condition. As such, understanding and strengthening the natural defence mounted by our stomach cells is a logical and crucial step in preventing gastric cancer.

In this study, the researchers found that a protein named IL23A normally produced only by white blood cells is released by stomach cells when exposed to H. pylori. This demonstrates that IL23A is part of our stomach's defence against bacterial infection. At the same time, they found that production of IL23A by stomach cells requires RUNX3, a tumour suppressor gene that is frequently silenced in gastric cancer. The involvement of RUNX3 appears particularly important during inflammation and infection caused by the bacterium. Their observation makes an important connection: when stomach cells lose RUNX3, they become defective in their ability to respond to infection by H. pylori, making the stomach vulnerable to this carcinogenic bacterium.

Prof Ito said, "We have been studying the frequent inactivation of RUNX3 in gastric cancer for some time. Our latest findings show that an important consequence of losing RUNX3 is a compromised immunity and this will enable us to devise better protection against pathogens."

The study was supported by the Translational and Clinical Research Flagship Programme and the National Research Foundation of Singapore.

In the next phase of research, the team will focus on determining the function of the novel IL23A complex they discovered, as part of their overall strategy to combat H. pylori-induced gastric cancer. Concomitant application for patent protection of this work by NUS will facilitate industry involvement, so that this research can be effectively used to develop novel treatments to combat gastric cancer.


Contact: Kimberley Wang
National University of Singapore

Related medicine news :

1. NYU researchers find 18 percent of high school seniors smoke hookah
2. The Lancet: Sierra Leone researchers call for improved health surveillance and communication around Ebola crisis
3. GW researchers: Acute kidney injury and chronic kidney disease as interconnected syndromes
4. Cleveland Clinic researchers identify urgent need for Alzheimers drug development
5. Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
6. Researchers seek to tackle transplant tolerance using patients own T cells
7. Moffitt researchers develop new way to combat drug resistance for melanoma patients
8. Researchers estimate 5.8 million A&E visits occur after patients unable to see a GP
9. Researchers conduct comprehensive review of treatments for depression in cancer patients
10. Miriam Hospital researchers develop app focused on making obese adults less sedentary
11. Researchers home in on way to predict aggressiveness of oral cancer
Post Your Comments:
(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many ... the beholder, according to experts who offered insights and commentary in the current issue ... the full issue, click here . , For the American Society of Clinical ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
Breaking Medicine Technology: