Navigation Links
NTU gene research promises better treatment procedures for children with leukemia
Date:8/14/2014

A research team led by Nanyang Technological University (NTU) scientists have made a key finding which is expected to open up improved treatment possibilities for children suffering from leukaemia.

They found that two in three cases of acute lymphoblastic leukaemia, a type of cancer of the white blood cells, may be caused by mutations in one of the two key genes found in children. These genes are however more prevalent in those with Down syndrome.

This means that scientists can design better tailored treatment protocols, depending on which mutating gene is carried by the patient. Such treatments may include lower doses of anti-cancer drugs thus leading to fewer side effects.

Acute lymphoblastic leukaemia is the most common cancer in children, with 50 to 100 children diagnosed each year in Singapore. This gene discovery is good news for those with Down syndrome and the 20 per cent of children who do not respond well to standard therapy.

Children with Down syndrome have a 20 to 50 fold greater risk of developing this blood cancer. They are also prone to suffer a relapse and have a higher risk of dying from the side effects of therapy.

The discovery, made by an international team led by Professor Dean Nizetic from NTU's Lee Kong Chian School of Medicine, was published in the prestigious academic journal Nature Communications last week.

Prof Nizetic's team of experts in ageing and Down syndrome collaborated with researchers from the Queen Mary University in London and the universities of Geneva and Padua on this study.

"By analysing the DNA sequence of patient samples at different stages of the disease, we identified mutations in two genes that turn normal blood cells into cancer cells," said Prof Nizetic, the senior author of the study.

The research team found that the two genes (RAS and JAK) never mutate together, which makes them ideal biomarkers.

"This could benefit all c
'/>"/>

Contact: Lester Kok
lesterkok@ntu.edu.sg
65-679-06804
Nanyang Technological University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Irish research sheds light on how aspirin works to reduce cancer deaths
2. Scientists detail urgent research agenda to address chronic disease toll
3. ChanTest Announces a Global Campaign to Share New Findings and Developments in Cystic Fibrosis (CF) Research
4. New Research Finds Mesothelioma Surgery Outcomes Can Be Improved, According to Surviving Mesothelioma
5. Ethane Industry 2014 Development Trends in Global & China Regions in a New Study Available at DeepResearchReports.com
6. Researchers identify tests to diagnose invasive aspergillosis with 100 percent accuracy
7. Global Neuropathy Clinical Trials and Deep Analysis 2014 - Worldwide Market Size, Share, Trend, Forecasts, Growth and Research Report
8. Researchers Unlock Clues to How Ebola Disarms Immune System
9. ASTRO awards $35,500 in individual grants to 43 researchers presenting at the 2014 Annual Meeting
10. Caterers in Canada Industry Market Research Report Now Available from IBISWorld
11. Researchers uncover clues about how the most important TB drug attacks its target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... (PRWEB) October 01, 2014 Join the more ... Eating Disorder Treatment Center’s first ever charity golf tournament to ... people with eating disorders who cannot afford treatment. The tournament ... Club in Eureka, Mo. , The day-long event starts ... A reception and award dinner will begin at 5 p.m. ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Innovations announces ... scheduled to broadcast on Monday, October 20, 2014 at ... episode, Innovations will go behind the scenes to learn ... This segment will explore the practical help and information ... which teaches the warning signs of abuse, how to ...
(Date:10/1/2014)... Scientists at the University of Western Australia ... system proteins has the power to knock out mesothelioma ... the new study on their website. Click here ... the UWA School of Pathology and Laboratory Medicine administered ... mesothelioma with promising results. , “A timed triple ...
(Date:10/1/2014)... October 01, 2014 October is national ... and early detection plans while raising money for breast ... Breast Cancer Awareness Month in the effort to ... to promote the importance of having access to clean, ... may be linked to certain forms of cancer. ...
(Date:10/1/2014)... Two bicyclists began a journey on ... country in an effort to raise funds and awareness ... cyclists, a father-daughter team, plan to bike more than ... and finishing in Key West Florida. Funds raised ... a national nonprofit organization that assists post-9/11 service members, ...
Breaking Medicine News(10 mins):Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2Health News:New Mesothelioma Study Says Mice Cured by Immuntherapy “Cocktail”, Reports Surviving Mesothelioma 2Health News:Pelican Water Supports Breast Cancer Awareness Month with Order Donations 2Health News:Father-Daughter Cycling Duo to Ride Cross-Country to Benefit Hope For The Warriors 2
... Treatment Model Blends Eastern and Western Therapies to Create ... ... Feb. 13 Moonview Sanctuary, the exclusive,non-residential treatment and ... approaches practiced by more than 70,experts in their fields, ...
... SUINING, China, Feb. 13 /Xinhua-PRNewswire/ -- China Health ... that Jia Minru, famous,professor of the Chinese Medicine ... be responsible for deep development,high-tech development and systematic ... The joining of Jia Minru will certainly ...
... Calif., Feb. 12 Blue Cross of California,highly values ... members have with their physicians and medical groups. It ... and up to date,both for the benefit of our ... the ways we do this is to send the ...
... Event Name ... Same Commitment to ... the Health of all Babies, CINCINNATI, ... announce that 4-year-old Bradley,Coffey of Kennedy Heights and his family will serve ... as WalkAmerica,March for Babies is the March of Dimes premier fundraising event ...
... (OTC Bulletin Board: ECTE), a specialty pharmaceuticals and,diagnostics ... approximately,$2.3 million private financing with Montaur Capital through ... select institutional and strategic,investors of senior unsecured convertible ... principal amount of Senior Convertible,Notes to be issued ...
... 12 Edwards Lifesciences,Corporation (NYSE: EW ), the ... that it has filed a patent infringement lawsuit against,CoreValve, ... Court for,the District of Delaware. The suit seeks injunctive ... family of patents for transcatheter,heart valve technology., "Edwards ...
Cached Medicine News:Health News:High-End Treatment Center Moonview Sanctuary Unveils Four New Core Treatment Programs 2Health News:High-End Treatment Center Moonview Sanctuary Unveils Four New Core Treatment Programs 3Health News:Renowned Chinese Herbal Medicine Development Specialist Joins China Health Resources 2Health News:Local Families Chosen for Ambassador Role for 2008 March for Babies 2Health News:Local Families Chosen for Ambassador Role for 2008 March for Babies 3Health News:Echo Therapeutics Announces Closing of Approximately $2.3 Million Private Financing 2Health News:Echo Therapeutics Announces Closing of Approximately $2.3 Million Private Financing 3Health News:Edwards Lifesciences Initiates Patent Infringement Litigation Against CoreValve in the U.S. 2
(Date:10/1/2014)... , Oct. 1, 2014 ... now available. Interested parties can learn about ... Cardinal Health is supporting the health care ... http://cardinalhealth.com/annualreport . Photo- http://photos.prnewswire.com/prnh/20140930/149504-INFO ... summary financials and the chief executive officer,s ...
(Date:10/1/2014)... (NYSE: RMD ), a pioneer and innovator in ... sleep apnea solutions specifically for women, is launching a new ... night,s sleep. The Better Sleep For Women ... just part of living a busy life. It will encourage ... health, essential to not only living an active lifestyle but ...
(Date:10/1/2014)... 1, 2014  Varian Medical Systems (NYSE: ... for the fourth quarter of fiscal year 2014 following ... 2014.  The news release will be followed by a ... PT.  The news release and a link to the ... website at: www.varian.com/investor .  To access the teleconference ...
Breaking Medicine Technology:Cardinal Health 2014 Digital Report to Shareholders Now Available 2ResMed Launches Initiative to Help Women Get Better Sleep 2ResMed Launches Initiative to Help Women Get Better Sleep 3Varian Medical Systems Schedules Fourth Quarter FY2014 News Release and Conference Call 2
... 7 The 14th Annual Webby Awards named Regence BlueCross ... of Rich Media: Business to Consumer. More than a million people ... steep competition from companies that included Doritos® and NIKE. , ... The People,s Voice win ...
... May 7 Catalyst Pharmaceutical Partners, Inc. (NasdaqCM: ... Officer, will be making a presentation at the MoneyShow Conference ... at Caesars Palace in Las Vegas .  Catalyst will ... and CPP-115. Further, the Company reported that its presentation materials ...
Cached Medicine Technology:Regence BlueCross BlueShield Wins People's Voice Award for Online Consumer Campaign in the 14th Annual Webby Awards 2Regence BlueCross BlueShield Wins People's Voice Award for Online Consumer Campaign in the 14th Annual Webby Awards 3Catalyst Pharmaceutical Partners to Present at the MoneyShow Conference 2