Navigation Links
NTRK1: A new oncogene and target in lung cancer
Date:6/3/2013

To the list of oncogenic drivers of lung cancer that includes ALK, EGFR, ROS1 and RET, results of a University of Colorado Cancer Center study presented at ASCO 2013 show that mutations in the gene NTRK1 cause a subset of lung cancers.

"We're reconceptualizing lung cancer as many, related diseases. And we need to learn to identify and treat each individually. We can treat the forms of the disease that depend on ALK and EGFR mutations. We're getting very close to treating lung cancers that depend on ROS1 and RET. And now we show another oncogenic driver of the disease that begs its own targeted treatment," says Robert C. Doebele, MD, PhD, investigator at the CU Cancer Center and assistant professor of medical oncology at the CU School of Medicine.

The group, in collaboration with Pasi A. Jnne, MD, PhD from the Dana-Farber Cancer Institute, started with lung cancer tumor samples from 36 "pan-negative" patients, meaning that no other driver oncogene had been identified. So if not EGFR, ALK and the like, what was driving the cancer? Doebele and colleagues took the question to Foundation Medicine (Cambridge, MA), which used targeted, next-gen sequencing to analyze the samples for possible mutations in a couple hundred potential oncogenes identified as drivers of other cancers. NTRK1 had been identified as a driver of thyroid cancer and so was included in the panel (though drug development had stalled due in part to the relative rarity of the thyroid disease). Sure enough, next-gen sequencing identified NTRK1 gene fusions as the potential driver in two of these samples.

Doebele and colleagues took the lead back to the CU labs, where Marileila Varella Garcia, PhD, developed a specific test for NTRK1 fusions based on fluorescence in situ hybridization (FISH), similar to what is used for ALK, ROS1 and RET fusions. This allowed the group to validate the finding of NRTK1 as a novel oncogene in these patient samples.

But the study went
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New oncogene identified for breast cancer
2. Dietary glucose affects the levels of a powerful oncogene in mice
3. Hepatitis B virus promotes oncogenesis through microRNA modulation
4. Preclinical study identifies master proto-oncogene that regulates ovarian cancer metastasis
5. RET rearrangement a new oncogene and potential target in lung cancer
6. Targeted therapeutics for colon cancer to be presented at AACR meeting
7. First targeted nanomedicine to enter human clinical studies
8. SMART heart eases heart ache, targets cardiac patients emotional well-being
9. Target set on cancer gene MCL1
10. Scientists tailor cell surface targeting system to hit organelle ZIP codes
11. IBN discovers human neural stem cells with tumor targeting ability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014 As part of ... care service in San Diego and surrounding ... its senior care team with ongoing online training ... Care is provided by Caregiverlist®. Caregiverlist® is ... with the most reliable eldercare options, highest quality ...
(Date:12/22/2014)... December 22, 2014 Sagacious Consultants, the ... a subscription option to their ad hoc report writing ... services. Customers can sign up for an annual subscription ... each month at a deeply discounted hourly rate. ... each has a progressively discounted rate. Subscription hours are ...
(Date:12/22/2014)... NC (PRWEB) December 22, 2014 ... the current Ebola virus epidemic are receiving ... U.S. government agencies, nongovernmental organizations (NGOs) and ... remains ongoing, healthcare workers, emergency responders, patients ... technologies such as the CmTP MediDefense ...
(Date:12/22/2014)... The Bob Woodruff Foundation will ... more than $5 million in programs and organizations ... families. , This includes $1.3 million in grants ... with: veteran entrepreneurship; community impact; vocational training; transportation; ... injured veterans. , “The needs of those injured ...
(Date:12/22/2014)... Give a loved one the greatest gift of ... vitality. , For a limited time, HealthiPlus ( https://healthiplus.com/christmas-gift-packages/ ... special Holiday Wellness gift packages at drastically reduced prices ... contains cutting-edge, proven nutritional support for joints, mental functioning ... we age. , Joint Health Plus contains ...
Breaking Medicine News(10 mins):Health News:Golden Care Partners with Nationally Recognized Caregiver Training Service 2Health News:Sagacious Consultants’ New Subscription Packages Offer Customers Additional Report Writing Options 2Health News:Sagacious Consultants’ New Subscription Packages Offer Customers Additional Report Writing Options 3Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 2Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 3Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 4Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2
... Suicidal teens are not likely to get the ... team of researchers at Seattle Children,s Research Institute, the ... The study, "Adolescents With Suicidal Ideation: Health Care Use ... . The researchers found that only 13 ...
... (September 2011) Research conducted by Boston College neuroscientist Sean ... finds evidence of a new way of considering how the ... paper published in the latest issue of Nature Neuroscience ... magnetic resonance image (fMRI) to help them identify how the ...
... By Jenifer Goodwin HealthDay Reporter , TUESDAY, ... of lymph nodes after colon cancer surgery does not seem ... Researchers from the U.S. National Cancer Institute analyzed data ... and End Results (SEER) cancer registry. The investigators found ...
... Medicine have found that thyroid-stimulating hormone (TSH), a hormone ... function in the thyroid gland, can promote bone growth ... that TSH, or drugs that mimic its affect on ... osteoporosis and other conditions involving bone loss, such as ...
... (HealthDay News) --,Statins, a widely prescribed class of drugs used ... of brain bleeds in people who,ve had strokes, new research ... an ischemic stroke, caused by blocked blood flow to the ... two previous reviews raised concerns that statins might also raise ...
... previously unrelated imaging tools into one new device, a ... the University of Southern California has proposed a new ... through minimally invasive surgery. The new technique may be ... the ovaries. Ovarian cancer has a low ...
Cached Medicine News:Health News:Study finds over 70 percent of suicidal teens don't get the mental health services they need 2Health News:Study finds over 70 percent of suicidal teens don't get the mental health services they need 3Health News:Researchers utilize neuroimaging to show how brain uses objects to recognize scenes 2Health News:Screening Lots of Lymph Nodes Little Help for Colon Cancer Patients 2Health News:Screening Lots of Lymph Nodes Little Help for Colon Cancer Patients 3Health News:Pituitary hormone TSH found to directly influence bone growth 2Health News:Statins Don't Raise Risk of Brain Bleeds After Stroke: Study 2
(Date:12/19/2014)... the Friday, December 19 edition of USA ... (HIT) features Konica Minolta, the company announced today. The supplement will ... healthcare organizations. In addition to the print section ... New York , Chicago , ... Minneapolis and San Francisco , ...
(Date:12/19/2014)... , Dec. 19, 2014  Advanced Medical Isotope ... company engaged primarily in the development of brachytherapy ... applications, today announced that a Life Sciences Discovery ... awarded for which AMIC is the commercialization partner.  ... (WSU) for the proposal titled "Optimized Injectable Radiogels ...
(Date:12/19/2014)... , Dec. 19, 2014 In ... research and marketing communication tools are essential for ... competitive – consequently consumers, desires, preferences, and unmet ... environment, market research groups across all industries are ... communication tools. However, the adoption of new market ...
Breaking Medicine Technology:USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 3Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2
... VenaCure Laser Vein Treatment. It is estimated ... worldwide have varicose veins. In the United States, ... of 60 suffer from painful and unsightly venous ... the capabilities of vascular therapy for the treatment ...
ELVeS is a new minimally-invasive laser treatment for patients with superficial vein reflux of the greater saphenous vein. The ELVeS laser treatment offers your patients an effective out-patient alt...
... technology provides practitioners with the ability to treat ... permanent hair reduction on all skin types and ... the practitioner to instantly switch to a 3, ... a simple twist of the handpiece dial while ...
... people are diagnosed with varicose veins every ... never seek treament and are apprehensive of ... them an effective alternative to conventional therapies., ... hook phlebectomy), is considered a laborious procedure ...
Medicine Products: