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NSU researchers receive $4.1 million grant from DOD to investigate Gulf War illness
Date:11/19/2013

GWI research program is the investment in a lasting infrastructure of relationships among the participating organizations fostering continuing research collaborations and future clinical trials focused on GWI.

GWI is a medical condition that affects veterans and civilians who were exposed to a number of dangers, including chemical weapons, during the 1991 Gulf War. Symptoms can include chronic headaches, widespread pain, cognitive difficulties, debilitating fatigue, gastrointestinal problems, respiratory symptoms, and other abnormalities that are not explained by established medical diagnoses or standard laboratory tests. At least a quarter of the nearly 700,000 soldiers who fought in the Gulf War suffer from GWI, according to the U.S. Department of Veterans Affairs' Research Advisory Committee on Gulf War Veterans' Illnesses.

"Our goal is to develop a better understanding of GWI and understand specific causes so we can find treatments to address these causes, rather than focus on the symptoms," said Klimas. "This consortium will integrate our clinical understanding of the disease process with basic research efforts using a novel mathematical model."

It has been established that GWI is caused by a disruption in normal cell signaling that results in disabling symptoms including fainting, low blood pressure, fatigue, and pain. This is primarily due to disruptions in normal immune, cardiovascular, and hormone signaling.

However, the exact cause of this disruption is not well understood. The goal of the consortium is to pinpoint the causes of GWI using a multidisciplinary approach. The project will involve integrating basic and clinical research using a computational systems biology method to correlate data between the physiological compartments and levels of biology from basic models to human patients. This will allow them to tailor treatment more effectively using drugs already approved for other illnesses.

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Contact: Jeremy Katzman
j.katzman@nova.edu
954-262-5408
Nova Southeastern University
Source:Eurekalert  

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NSU researchers receive $4.1 million grant from DOD to investigate Gulf War illness
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