Navigation Links
NSU researchers receive $4.1 million grant from DOD to investigate Gulf War illness
Date:11/19/2013

FORT LAUDERDALE-DAVIE, Fla.- Nova Southeastern University (NSU) President and CEO George L. Hanbury II, Ph.D., recently announced that a NSU research team led by Mariana Morris, Ph.D., and Nancy Klimas, M.D., was selected by the U.S. Department of Defense (DoD) as one of two DoD Gulf War Illness Research Program Consortium awardees.

The award includes a $4.1 million grant to fund NSU's research project titled "Understanding Gulf War Illness (GWI): An Integrative Modeling Approach." The research will be housed in the Institute for Neuro Immune Medicine, part of NSU's College of Osteopathic Medicine.

"Projects like this help us fulfill our core value to conduct research that not only advances human knowledge, but makes a real difference for mankind," said Hanbury.

The consortium combines leading scientific researchers with expertise in basic and clinical research along with those with expertise in stress response and heart function models, genomics, computational models that isolate therapeutic targets, and guide drug development, formulation and testing.

"This grant allows us to find ways to help hundreds of thousands of men and women who risked everything to serve their country and are now facing adverse health effects," added Gary S. Margules, Sc.D., NSU vice president for research and technology transfer.

"This consortium provides an opportunity to advance our understanding of Gulf War Illness through discovery of biomarkers to more accurately diagnose and treat this syndrome," said Col. Wanda Salzer, M.D., director of Congressionally Directed Medical Research Programs (CDMRP). "Working as an integrated team, the scientists, clinicians, and veterans at these accomplished organizations will be able to establish synergy and collectively develop research strategies which may unlock the pathways leading to the regulatory dysfunction in Gulf War Illness."

Col. Salzer added that the long-term goal of the CDMRP GWI research program is the investment in a lasting infrastructure of relationships among the participating organizations fostering continuing research collaborations and future clinical trials focused on GWI.

GWI is a medical condition that affects veterans and civilians who were exposed to a number of dangers, including chemical weapons, during the 1991 Gulf War. Symptoms can include chronic headaches, widespread pain, cognitive difficulties, debilitating fatigue, gastrointestinal problems, respiratory symptoms, and other abnormalities that are not explained by established medical diagnoses or standard laboratory tests. At least a quarter of the nearly 700,000 soldiers who fought in the Gulf War suffer from GWI, according to the U.S. Department of Veterans Affairs' Research Advisory Committee on Gulf War Veterans' Illnesses.

"Our goal is to develop a better understanding of GWI and understand specific causes so we can find treatments to address these causes, rather than focus on the symptoms," said Klimas. "This consortium will integrate our clinical understanding of the disease process with basic research efforts using a novel mathematical model."

It has been established that GWI is caused by a disruption in normal cell signaling that results in disabling symptoms including fainting, low blood pressure, fatigue, and pain. This is primarily due to disruptions in normal immune, cardiovascular, and hormone signaling.

However, the exact cause of this disruption is not well understood. The goal of the consortium is to pinpoint the causes of GWI using a multidisciplinary approach. The project will involve integrating basic and clinical research using a computational systems biology method to correlate data between the physiological compartments and levels of biology from basic models to human patients. This will allow them to tailor treatment more effectively using drugs already approved for other illnesses.

At the end of the four-year study, the consortium plans to complete early studies in human patients and be able to pursue larger-scale clinical trials for further drug testing.

"By increasing the understanding of the reasons for GWI, our consortium will advance the diagnosis and treatment of the disease," said Morris. "Specifically, our more detailed understanding of the dysfunction involved in GWI would greatly increase the speed to identify targets for improved diagnosis as well as selection and testing of more specific treatments over the longer term that will address the causes of disease."

The consortium consists of co-principal investigators Mariana Morris, Ph.D., NSU professor and director of Gulf War research, and Nancy Klimas, M.D., director of NSU COM's Institute for Neuro Immune Medicine; Gordon Broderick, Ph.D., NSU Center for Psychological Studies; Travis Craddock, Ph.D., assistant professor, NSU Center for Psychological Studies; NSU-COM's Institute for Neuro Immune Medicine genomics core, and Mary Ann Fletcher, Ph.D., NSU-COM's Schemel Professor for Neuro Immune Medicine. The team is affiliated with the research service of the Bruce W. Carter Department of Veterans Affairs Medical Center and Miami VA Healthcare System. Klimas is also affiliated with the VA's medical service.


'/>"/>

Contact: Jeremy Katzman
j.katzman@nova.edu
954-262-5408
Nova Southeastern University
Source:Eurekalert  

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NSU researchers receive $4.1 million grant from DOD to investigate Gulf War illness
(Date:2/5/2016)... SARASOTA, Florida (PRWEB) , ... February 05, 2016 , ... ... an event he has completed every year since it started in 2003. This year, ... attracting the attention of fellow runners and NBA team the Miami Heat. , This ...
(Date:2/5/2016)... ... February 05, 2016 , ... Successful recruitment and ... clinical and scientific initiatives have all marked the last 12 months at Roswell ... CEO of the nation’s oldest cancer center, Candace S. Johnson, PhD, outlined the ...
(Date:2/5/2016)... New York, New York (PRWEB) , ... February 05, 2016 , ... ... your life? The answer may be at the tips of your toes. Foot massage, ... benefits as well as pure comfort and relaxation. The American Board of Multiple ...
(Date:2/5/2016)... Rafael, CA (PRWEB) , ... February 05, 2016 , ... ... with ChildLight Yoga Studio in Dover, NH to direct high-performance kids yoga training. ChildLight ... New Hampshire’s seacoast, just one hour from Boston. , ChildLight Yoga Studio founder Lisa ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure ... to search for and donate to Give To Cure’s campaign that is crowdfunding clinical ... lets users make and share payments through a smart device. In 2015 alone, Venmo ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016 Global Immunology Market ... to drive long-term market growth Summary ... of chronic disorders that affect 5–7% of western ... of their symptoms and key patient demographics, they ... immune pathways and an inappropriate immune response. Generally, ...
(Date:2/4/2016)... -- Omnicell, Inc. (NASDAQ: OMCL ), a leading provider of ... announced results for its fiscal year and fourth quarter ... --> GAAP results: Revenue for the fourth quarter ... 4.1% from the third quarter of 2015, and up ... 2014. Revenue for the year ended December 31, 2015 was ...
(Date:2/4/2016)...  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... treat life-threatening diseases, today announced results for the ... 2015. --> --> ... our last quarterly call, we strategically advanced pre-clinical ... to establish the Aethlon Hemopurifier® as a leading ...
Breaking Medicine Technology: