Navigation Links
NSAIDs Might Lower Breast Cancer Risk

Analysis of 38 studies found painkillers showed protective effect

THURSDAY, Oct. 9 (HealthDay News) -- Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a reduced risk for breast cancer, a new review suggests.

But the findings aren't an invitation for all women to start popping the popular painkillers, the researchers added.

"We don't want that to happen here, for people to jump on the bandwagon and start taking aspirin or ibuprofen," said study senior author Mahyar Etminan, an assistant professor of medicine at the University of British Columbia. "A lot of people are taking these drugs for aches and pains, and aspirin to prevent cardiac events. Those people may actually get an added benefit, but, for someone relatively healthy, we don't recommend starting to [reduce breast cancer risk] as of yet."

"From a practitioner's standpoint, it's kind of reassuring to patients if they do take NSAIDs for whatever reason," added Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, La. "I don't think women should be taking these medicines for prevention, but if they are taking them for other reasons like heart prevention or arthritis, this should be reassuring."

The study is in the Oct. 15 issue of the Journal of the National Cancer Institute.

Use of NSAIDs has been linked to a lower risk of cancer overall, particularly colon cancer, and even to a lower risk of breast cancer, although studies looking specifically at breast cancer have produced inconsistent results.

With colleagues at the University of Santiago de Compostela in Spain, Etminan reviewed mostly observational studies which, together, involved a total of almost 3 million women.

The analysis included the group of NSAIDs known as cox-2 inhibitors, only one of which, Celebrex (celecoxib), is still on the market.

NSAID use across all participants in all studies was associated with a 12 percent lower risk of developing breast cancer. Aspirin was associated with a 13 percent reduced risk, and ibuprofen with a 21 percent reduced risk.

Different doses did not yield different results.

The authors acknowledged that, given that almost all of the studies reviewed were observational, this analysis may be subject to the certain limitations, and all such analyses are only as good as the studies they review.

On the other hand, the review was a large one and has biological plausibility. The inhibition of the enzyme cyclooxygenase (COX) is thought to be one of the ways NSAIDs might reduce cancer risk. And, according to an accompanying editorial, cox-2 is over expressed by 40 percent in invasive breast cancer and 80 percent in colorectal cancer.

At the very least, the results should prompt further research.

"The question is, how can you apply these results? These drugs are widely used but not without side effects. You're not going to put someone on ibuprofen long-term, because it's not going to help the stomach, and there are kidney effects," said Dr. Debra Monticciolo, a professor of radiology at Texas A&M Health Science Center and vice chair of research in the radiology department and chief of breast imaging at Scott & White Hospital. "This is preliminary. You're looking at an observational meta-analysis. It's not the strength of a randomized, controlled trial. You want long-term efficacy and long-term safety data. We need more information."

A randomized trial looking at the protective effect of Celebrex on breast cancer is due to be completed in 2009, Etminan said.

More information

The American Cancer Society has more on breast cancer.

SOURCES: Mahyar Etminan, Pharm.D., assistant professor, medicine, University of British Columbia; Jay Brooks, M.D., chairman, hematology/oncology, Ochsner Health System, Baton Rouge, La.; Debra Monticciolo, M.D., professor, radiology, Texas A&M Health Science Center, and vice chair, research, radiology department, and chief, breast imaging, Scott & White Hospital; Oct. 15, 2008, Journal of the National Cancer Institute

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
2. NSAIDs No Better for Low Back Pain
3. NSAIDs Protect Against Parkinsons Disease
4. Link Uncovered Between Benign Prostatic Hyperplasia and NSAIDs, Says Harvard Mens Health Watch
5. Using coxibs and NSAIDs to treat osteoarthritis
6. Spoonful of Sugar Really Might Help Medicine Go Down
7. HIV Drug Might Spur Resistant Strains of Virus
8. Exercise Might Slow Brain Shrinkage in Alzheimers Patients
9. When it comes to putting, Tiger and Nicklaus might not have best advice
10. Popular Tilapia Might Not Help Heart
11. Vaginal Microbicides Might Help More Men Than Women
Post Your Comments:
Related Image:
NSAIDs Might Lower Breast Cancer Risk
(Date:12/1/2015)... FL (PRWEB) , ... December 01, 2015 , ... ... announces the Multi Jar, a container patent that allows for easier packing and organizing ... the US is worth $90 billion," says Scott Cooper, CEO and Creative Director of ...
(Date:12/1/2015)... ... ... Royal River Natural Foods — a locally-owned, independent natural health store in ... nutritional supplement creatine, along with resistance training for a year, had more new bone ... report is part of the December 2015 issue of Natural Insights for Well Being®, ...
(Date:12/1/2015)... ... December 01, 2015 , ... According to an article published ... discrimination claim against the U.S. Department of Health and Human Services, claiming that any ... plans are breaking the clause in the law prohibiting the denial of coverage for ...
(Date:12/1/2015)... ... December 01, 2015 , ... Califia Farms , one of ... iconic bottle has won top honors in Beverage World Magazine’s Global Packaging Design Awards, ... that it has been selected as a 2015 U.S.A. Taste Champion in the American ...
(Date:12/1/2015)... ... ... Growth in medical payments per workers’ compensation claim in Louisiana slowed from ... care, according to a recent study by the Workers Compensation Research Institute (WCRI). ... payments per claim with more than seven days of lost time continued to be ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 2015 ... "Medium Molecular Weight Polyisobutylene Market for ... Applications - Global Industry Analysis, Size, Share, ... report to their offering. --> ... of the "Medium Molecular Weight Polyisobutylene ...
(Date:12/1/2015)... /PRNewswire/ -- Royal Philips  (NYSE: PHG, ... imaging software that produces high-contrast images for all anatomies ... grid, at the 2015 Radiological Society of North ... Philips, first digital imaging solution providing grid-like contrast improvement ... workflow and supports "first-time-right imaging" by decreasing the need ...
(Date:12/1/2015)... 2015  Athletic apparel company Tommie Copper ... pay $1.35 million to settle Federal Trade Commission ... compression clothing would relieve severe and chronic pain ... Tommie Copper,s proposed settlement ... its founder and chairman Thomas Kallish ...
Breaking Medicine Technology: