Navigation Links
NSAIDs May Raise Miscarriage Risk: Study
Date:9/6/2011

By Amanda Gardner
HealthDay Reporter

TUESDAY, Sept. 6 (HealthDay News) -- Women who take nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen during the first stage of their pregnancy may be upping their risk of miscarriage, new research suggests.

"We're seeing a 2.4-fold increased risk in spontaneous abortion following early use of NSAIDs during pregnancy," said Anick Berard, senior author of a paper published in the Sept. 6 issue of the Canadian Medical Association Journal.

Although the study was not a randomized, controlled trial -- considered the gold standard of science -- Berard thinks the results are due to the medication and not some other, unrelated factor.

"We went through a lot of pain and misery to make sure what we're seeing is due to the drug and not a consequence of symptoms [of an underlying illness] or risk attributed to rheumatoid arthritis, for example," said Berard, who is director of the Research Unit on Medication and Pregnancy at St. Justine Hospital in Montreal.

And while the study only looked at prescribed NSAIDs, Berard believes the risk would also be present in over-the-counter NSAIDs.

Rheumatoid arthritis, lupus, migraine and various other conditions are routinely treated with pain-killing NSAIDs. The drugs are also used for pain relief in people who don't have chronic underlying illnesses and are one of the most commonly used medications both outside and during pregnancy.

Physicians already shy away from using NSAIDs in later stages of pregnancy because they can interfere with healthy development of fetal circulation, said Dr. Joseph I. Fernandez, division director of obstetrics and gynecology at Scott & White Healthcare in Round Rock, Texas.

Berard and her colleagues looked at a different time of pregnancy: the first 20 weeks.

The study incorporated data on almost 5,000 women in Quebec who had miscarried and compared these women with 50,000 women who had not miscarried.

In general, women who had used NSAIDs during this earlier part of pregnancy had a 2.43-fold increased risk of miscarriage. They were considered to be using NSAIDs if they had filled at least one prescription just prior to being pregnant or in the 20 weeks after conceiving.

Individual drugs had different risks associated with them, the highest being diclofenac, which tripled the risk, naproxen (Aleve), which involved a 2.64-times increased risk and ibuprofen (Advil, Motrin), which carried about double the risk.

Combinations of drugs were associated with a 2.64-times increased risk. That so many of the drugs involved a raised risk indicates a class effect, the authors stated.

Although no one is quite sure how NSAIDs might induce miscarriage, the authors theorized that they may interfere with levels of hormones called prostaglandins, which are involved in inducing labor.

For women who need NSAIDs for occasional pain relief, such as for headaches, "acetaminophen is a good and safe alternative early in pregnancy," said Berard, who is also professor of pharmacy at the University of Montreal.

Fernandez added: "I tell patients to avoid NSAIDs during pregnancy. For minor aches and pains, we'll have them take acetaminophen as instructed."

For women who take NSAIDs on a continual basis -- say, for rheumatoid arthritis or lupus -- "it is better to plan the pregnancy and discuss treatment options beforehand," Berard said. "Surprisingly, women with rheumatic diseases improve during pregnancy naturally."

More information

The U.S. Office on Women's Health has more on pregnancy.

SOURCES: Anick Berard, Ph.D., professor, pharmacy, University of Montreal, and director, Research Unit on Medication and Pregnancy, St. Justine Hospital, Montreal; Joseph I. Fernandez, M.D., division director, obstetrics and gynecology, Scott & White Healthcare, Round Rock, Texas; Sept. 6, 2011, Canadian Medical Association Journal


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Pitt study finds NSAIDs cause stem cells to self-destruct, preventing colon cancer
2. NT-proBNP is a predictor of CV risk in arthritis patients taking NSAIDs
3. NSAIDs Wont Shield Against Skin Cancer
4. Aging, Not Menopause, Raises Womens Heart Risks, Study Finds
5. Commonly used defibrillators raise risk of problems
6. Smoking soon after waking raises risk of lung and head and neck cancers
7. Trying to Be Supermom Can Raise Risk for Depression
8. Central Catheters May Raise Risk of Blood Clots After Surgery
9. Obesity Before Pregnancy May Raise Childs Asthma Risk
10. Depressed Women Could Face Raised Risk of Stroke
11. Breast Cancer Drug Raises Risk of Heart Problems in Older Women: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NSAIDs May Raise Miscarriage Risk: Study
(Date:5/21/2017)... ... May 21, 2017 , ... For more than 20 years ... wide range of knives and swords, from functional to fantasy. United Cutlery has always ... sleek, modern designs that defy tradition. , Offering a range of weapons and tools ...
(Date:5/21/2017)... ... May 21, 2017 , ... Dental visits are often ... since you've seen a dentist, it's time for a dental checkup. The American ... per year. , Dental checkups are a relatively easy procedure that involves visually ...
(Date:5/19/2017)... Charlotte, NC (PRWEB) , ... May 19, 2017 ... ... of the Charlotte health community, Queens University of Charlotte recently began recruitment efforts ... The program’s curriculum arms students with the skills, knowledge and expertise to approach ...
(Date:5/19/2017)... Mo (PRWEB) , ... May 19, 2017 , ... When ... May 20, his name will already appear on two major research studies that could ... been working with Dr. Matt Daggett, KCU alumnus and an orthopedic surgeon, alongside an ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Hill Agencies, a family ... entrepreneurs throughout the California Central Valley, is announcing a joint charity initiative with the ... for a local kid’s camp event. , The Boys and Girls Club of Kern ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... Provista , a proven leader in the supply chain industry ... Jim Cunniff as the company,s new president and CEO. ... Provista, including most recently serving as the president and CEO ... He assumed his new role with Provista on May 1, ... says Jody Hatcher , president, Sourcing and Collaboration Services ...
(Date:5/4/2017)... Clarius Mobile Health, a digital healthcare ... this week at the American Congress of Obstetricians ... San Diego, CA from May ... perfect tool for clinicians to easily confirm pregnancy, ... pregnancy-related complications like ectopic pregnancy and placenta previa," ...
(Date:5/3/2017)... 3, 2017 A Catheterization Laboratory is ... healthcare facility. Commonly referred to as cath lab, ... diagnostic imaging technology to give physicians visual access ... these spaces, a team of physicians perform life-saving ... coronary intervention, congenital heart defect closure, stenotic heart ...
Breaking Medicine Technology: