Navigation Links
NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
Date:3/26/2008

Researchers at the National Sun Yat-Sen University and Kaohsiung Medical University, Kaohsiung, Taiwan have revealed a new mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) attenuate tumor invasion and metastasis. The research, to be published in the April 2008 issue of Experimental Biology and Medicine, provides new insights for the understanding of the anti-cancer effects of NSAIDs.

NSAIDs have been used for the suppression of pain and inflammation in the clinic for many years. The main targets of these drugs are cyclooxygenases (COXs) which play critical roles in maintaining physiological homeostasis, mediating inflammatory reactions and promoting tumorigenesis. However, COX-independent effects are also important for the inhibition of cancer development by NSAIDs. Indeed, NSAIDs are considered as a novel class of effective chemopreventive drugs.

The research team, led by Wen-Chun Hung, Dean of College of Science, National Sun Yat-Sen University, and a recent doctorial graduate Mei-Ren Pan and two collaborators Hui-Chiu Chang and Lea-Yea Chuang of Kaohsiung Medical University found that NSAIDs up-regulated several anti-metastatic genes including secreted protein acidic and rich in cysteine (SPARC), thrombospindin-1 (TSP-1), TSP-3 and tissue inhibitors of metalloproteinase-2 (TIMP-2) in human lung cancer cells. Our functional assay suggested that increases of SPARC and other anti-metastatic genes were important for NSAIDs to inhibit tumor invasion and metastasis said Wen-Chun Hung. More importantly, we elucidated the underlying mechanism and demonstrated that up-regulation of SPARC in human lung cancer cells was mediated via inhibition of DNA methyltransferases (DNMTs) expression and promoter de-methylation. This is the first report to show that NSAIDs may inhibit the expression of DNMTs to reverse promoter methylation and to reactivate gene transcription.

The researchers say that hypermethylation of tumor suppresso
'/>"/>

Contact: Dr. Wen-Chung Hung
hung1228@ms10.hinet.net
886-752-52000 x5817
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cerimon to Conduct a Proof of Concept Study for Basiliximab for Noninfectious Uveitis, a Potentially Sight-Threatening Inflammation of the Eye
2. Sirion Therapeutics Receives NDA Acceptance and Priority Review From the FDA for Durezol(TM) in the Treatment of Postoperative Ocular Inflammation
3. A Once-Daily Oral Drug for Chronic Obstructive Pulmonary Disease That Treats COPD-Related Inflammation Could Achieve Blockbuster Status
4. Overweight Hispanic children shown to have vascular inflammation
5. Anti-Inflammatory Drug Improves Glycemia, Lowers Inflammation in Obese, Young Adults
6. TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks
7. Cell-death receptor links cancer susceptibility and inflammation
8. iNOS expression may links chronic biliary inflammation to malignant transformation
9. Diabetes Linked to Blood Vessel Inflammation
10. Low-carb diet reduces inflammation and blood saturated fat in metabolic syndrome
11. Researchers develop powerful tool to study the genetics of inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... (PRWEB) July 30, 2014 Nationally recognized ... CNE, ANEF, who since September 2013 has served as ... became the new dean of the College of Nursing ... move marries her leadership of the NLN, as the ... the top-ranked academic nursing and research institutions in the ...
(Date:7/30/2014)... Within weeks freshman will begin to pour onto college ... will be a time of growth and the start to something ... may not be as easy as it looks. Some sources ... major at least once and many will switch two or three ... are exacerbated when switching in the later years of college. According ...
(Date:7/30/2014)... Throughout the month of August, Restore ... cancer screenings. Using a new technological tool called The ... disease in its early stages. , Oral cancer can ... throat and other areas in and around the mouth. ... Ends Results (SEER) program, 30 percent of oral cancers ...
(Date:7/30/2014)... Cucamonga, CA (PRWEB) July 30, 2014 Serial ... learning how to make millions. However, like most people, in ... Determined to find a better way, Paul carefully studied ... wealth and those who do not. Based on the knowledge ... to not only improve his life and health, but also ...
(Date:7/30/2014)... HealthDay Reporter WEDNESDAY, July 30, 2014 ... to develop dementia, but researchers have been unable to explain ... Specifically, they haven,t been able to figure out the direction ... on dementia, or does dementia cause people to become depressed? ... journal Neurology sheds more light on the mystery. ...
Breaking Medicine News(10 mins):Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 2Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 3Health News:Advice to College Freshman from Author Garrett Miller 2Health News:Advice to College Freshman from Author Garrett Miller 3Health News:Restore Dental Offers Complimentary Oral Cancer Screenings in August 2Health News:Paul Mata Kicks off 3-day Wealth Bootcamp on September 11th 2Health News:Paul Mata Kicks off 3-day Wealth Bootcamp on September 11th 3Health News:Scientists Shed Light on Link Between Depression, Dementia 2Health News:Scientists Shed Light on Link Between Depression, Dementia 3
... for UGIB should be performed within 24 hour from the admission. ... it should be performed either very early i.e. within 2 ... 6, 12 or 24 hour. Therefore, optimal timing for urgent endoscopy ... article to be published on August 28, 2008 in the ...
... 9 Heritage Victor Valley,Medical Group announced today ... Club. The Victorville Senior Citizen Club sponsors,educational, social ... The computers will be used for work stations ... programs at the Club., "The Victorville Senior ...
... Brinks Hofer Gilson & Lione, one of,the largest intellectual ... that Jacob Cheung-Ka Ong has joined the firm,s Salt ... Cheung-Ka Ong received a B.S. in neuroscience from Brigham ... University of,California-San Diego, La Jolla. He received his J.D. ...
... Bias Correction of Familial Risk Estimates Increases Estimated Melanoma ... , The relative risk of familial melanoma increases substantially ... a large cohort study. The relative risk of familial ... substantially with the correction. , Researchers have used the ...
... (Sept. 9, 2008) Both higher fish consumption and ... development in infants, according to a study of mothers ... breastfeeding were independently beneficial. , "These results, together with ... and the United Kingdom, provide additional evidence that moderate ...
... Firm Will Grow Through Leadership Development and Technological Efficiency ... ... Ga. (Vocus) September 9, 2008 -- http://www.jacksonhealthcare.com/companies.aspx ... of Alpharetta, Ga.-based http://www.locumtenens.com/new_leader08 [LocumTenens.com]. Working ...
Cached Medicine News:Health News:Also in the Sept. 9 JNCI 2Health News:Also in the Sept. 9 JNCI 3Health News:Eating fish while pregnant, longer breastfeeding, lead to better infant development 2Health News:Eating fish while pregnant, longer breastfeeding, lead to better infant development 3Health News:R. Shane Jackson Named President of LocumTenens.com 2Health News:R. Shane Jackson Named President of LocumTenens.com 3
(Date:7/31/2014)... BRUSSEL , 31 juli 2014 De ... van een rekruteringscampagne voor gezonde vrijwilligers van Japanse komaf ... Brussel gevestigde PCRU is één van twee ... met als ideaal levens te verbeteren door de ontdekking ... is de PCRU op zoek naar mannen en vrouwen ...
(Date:7/30/2014)... , July 30, 2014  There is ... chain organization,s success. The 10th Annual Institute for ... Awards for Excellence in Supply Management is open ... further the understanding and importance of supply management ... leadership and best supply management practices.  Entries are ...
(Date:7/30/2014)... -- Advanced Photonix ® (NYSE MKT: API) will announce ... on Monday, August 11, 2014. A press release announcing the ... market and the Company will host a live audio web ... the same day. Participating in the call will ... Risser (COO and Director), and Jeff Anderson ...
Breaking Medicine Technology:Gezonde vrijwilligers van Japanse komaf gezocht voor deelname aan Fase I klinisch onderzoek 2Institute for Supply Management, Michigan State University to recognize companies with excellent supply management practices 2Advanced Photonix to Webcast Fiscal 2015 First Quarter Earnings 2
... Approximately one-half of all infants are infected with the respiratory ... all children have been infected at least once by the time ... have discovered what makes RSV such a severe and persistent illness. ... his team have discovered that RSV prompts the release of a ...
... Australia, Sept. 3 Cytopia Limited,s (ASX: CYT) Investigational New ... Drug Administration (FDA) review. CYT387 is a small-molecule oral JAK1/JAK2 ... IND application is now active and Cytopia is able to ... , , CYT387 will be the second ...
Cached Medicine Technology:Researchers Find Common Respiratory Virus Hijacks Lung Cells to Stay Alive 2Researchers Find Common Respiratory Virus Hijacks Lung Cells to Stay Alive 3Cytopia's CYT387 Receives FDA Clearance to Start US Clinical Trials 2
Length-9 (229 mm) Tapered retractor blades....
Pattie Tray...
... blades are designed for the retraction of ... as well as brain retraction. Equalized brain ... edge of retractor. Range of blade sizes ... and release, malleable material allows preferred contour. ...
The Budde Halo Retractor Side Rail Support is designed for the adaptation and attachment of the Budde Halo Brain Retractor System to the operating room table when a conventional skull clamp is not us...
Medicine Products: