Navigation Links
NSAID use associated with lower colorectal cancer mortality rates among postmenopausal women

BOSTON Postmenopausal women who reported having used nonsteroidal anti-inflammatory drugs for at least 10 years at the time of enrollment in the Women's Health Initiative study had a lower risk for death from colorectal cancer compared with women who reported no use of these drugs at enrollment, according to data presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011.

"Our results suggest that nonsteroidal anti-inflammatory drug (NSAID) use is associated with lower colorectal cancer mortality among postmenopausal women who use these medications more consistently and for longer periods of time," said Anna E. Coghill, M.P.H., a doctoral student in epidemiology at the University of Washington and Fred Hutchinson Cancer Research Center.

She and her colleagues evaluated the association between aspirin and nonaspirin NSAID use and colorectal cancer mortality in 160,143 postmenopausal women enrolled in the Women's Health Initiative (WHI) who did not report a history of colorectal cancer at baseline. The study population included women enrolled in the WHI clinical trials and women enrolled in the WHI observational study.

"The WHI study population represents a large and well-characterized cohort of postmenopausal women, and the medication data collected in this cohort made it possible for us to investigate multiple types, durations and strengths of NSAID use," Coghill said.

Researchers confirmed 2,119 cases of colorectal cancer through medical reports and verified 492 deaths due to colorectal cancer through a centralized medical record and death certificate review.

Coghill and colleagues found that reported use of NSAIDs such as aspirin, ibuprofen and prescription NSAIDs at baseline, by itself, was not associated with colorectal cancer mortality.

However, women in the study who reported using NSAIDs at both study enrollment and three years after study enrollment had an approximately 30 percent lower rate of death due to colorectal cancer compared with women who reported no NASID use or use at only one of these two time points. Researchers also observed significant reductions in colorectal cancer mortality among women who reported at least 10 years of NSAID use at study enrollment compared with those who reported no use.

"The results of our study help to further clarify the importance of different durations of NSAID use over time for the risk for dying from colorectal cancer," Coghill said.


Contact: Jeremy Moore
American Association for Cancer Research

Related medicine news :

1. NSAIDs Wont Shield Against Skin Cancer
2. NT-proBNP is a predictor of CV risk in arthritis patients taking NSAIDs
3. Pitt study finds NSAIDs cause stem cells to self-destruct, preventing colon cancer
4. Long-term NSAID use by hypertensive patients with CAD increases risk of adverse events
5. NSAIDs May Raise Miscarriage Risk: Study
6. NSAID Painkillers Linked to Risk of Kidney Cancer
7. Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
8. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
9. Certain pain medications do not appear to be associated with skin cancer risk
10. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
11. New research shows emotional impact of low sexual desire and associated distress
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... EXTON, Pa. , Oct. 10, 2017   ... leader in innovative solutions for injectable drug administration, today ... of West,s ID Adapter for improving the intradermal administration ... the Fourth Skin Vaccination Summit in May 2017 by ... Team Lead, Polio Department, World Health Organization (WHO), and ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
Breaking Medicine Technology: