Navigation Links
NSAID use associated with lower colorectal cancer mortality rates among postmenopausal women
Date:10/23/2011

BOSTON Postmenopausal women who reported having used nonsteroidal anti-inflammatory drugs for at least 10 years at the time of enrollment in the Women's Health Initiative study had a lower risk for death from colorectal cancer compared with women who reported no use of these drugs at enrollment, according to data presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011.

"Our results suggest that nonsteroidal anti-inflammatory drug (NSAID) use is associated with lower colorectal cancer mortality among postmenopausal women who use these medications more consistently and for longer periods of time," said Anna E. Coghill, M.P.H., a doctoral student in epidemiology at the University of Washington and Fred Hutchinson Cancer Research Center.

She and her colleagues evaluated the association between aspirin and nonaspirin NSAID use and colorectal cancer mortality in 160,143 postmenopausal women enrolled in the Women's Health Initiative (WHI) who did not report a history of colorectal cancer at baseline. The study population included women enrolled in the WHI clinical trials and women enrolled in the WHI observational study.

"The WHI study population represents a large and well-characterized cohort of postmenopausal women, and the medication data collected in this cohort made it possible for us to investigate multiple types, durations and strengths of NSAID use," Coghill said.

Researchers confirmed 2,119 cases of colorectal cancer through medical reports and verified 492 deaths due to colorectal cancer through a centralized medical record and death certificate review.

Coghill and colleagues found that reported use of NSAIDs such as aspirin, ibuprofen and prescription NSAIDs at baseline, by itself, was not associated with colorectal cancer mortality.

However, women in the study who reported using NSAIDs at both study enrollment and three years after study enrollment had an approximately 30 percent lower rate of death due to colorectal cancer compared with women who reported no NASID use or use at only one of these two time points. Researchers also observed significant reductions in colorectal cancer mortality among women who reported at least 10 years of NSAID use at study enrollment compared with those who reported no use.

"The results of our study help to further clarify the importance of different durations of NSAID use over time for the risk for dying from colorectal cancer," Coghill said.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. NSAIDs Wont Shield Against Skin Cancer
2. NT-proBNP is a predictor of CV risk in arthritis patients taking NSAIDs
3. Pitt study finds NSAIDs cause stem cells to self-destruct, preventing colon cancer
4. Long-term NSAID use by hypertensive patients with CAD increases risk of adverse events
5. NSAIDs May Raise Miscarriage Risk: Study
6. NSAID Painkillers Linked to Risk of Kidney Cancer
7. Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
8. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
9. Certain pain medications do not appear to be associated with skin cancer risk
10. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
11. New research shows emotional impact of low sexual desire and associated distress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... ... August 23, 2017 , ... A new ... Orthopaedic Surgeons , points out that therapeutic modalities (physical therapy) is an important ... to the report, a wider scope of physical therapy options is showing promising ...
(Date:8/22/2017)... ... August 22, 2017 , ... The old adage ... as simple as eating healthy foods. But this well-known piece of nutrition advice ... or breaking apart carbohydrates—depends not only on properties of the food but also ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... solutions, announced recently the availability of a new professional fee E/M leveling calculator ... their service to the healthcare industry. E/M coding is complex which supports the ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Wilderness Voices”: a collection ... travel. “Wilderness Voices” is the creation of published author, Martha McKown, an ordained ... was inspired as a very young child when her older sisters studied High School ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... the Founder and Managing Member for t4 Leadership Development & Consulting. He has ... his definition of “success”: physician leadership development, servant leadership, data driven process improvement, ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Mostyn Law and Gulf Coast Regional Blood Center to host ... Mostyn Law family has had 3 members that needed ... Mostyn Law is partnering with Gulf Coast Regional Blood Center ... Blood supplies are running low. Gulf Coast Regional Blood Center,s ... August. That is why the blood center reached out to ...
(Date:8/15/2017)... Calif. , Aug. 15, 2017  AOTI Inc. announced today ... Oxygen Therapy Inc., has recently opened a New York City Office ... ever-increasing usage of its unique Topical Wound Oxygen (TWO 2 ) ... by the Accreditation Commission for Health Care (ACHC) under the company,s ... ...
(Date:8/8/2017)... Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), ... today reports its financial results for the second quarter ... during the second quarter 2017 and to date: ... clinical development programs for the Company,s lead project, BL-8040: ... pivotal study with BL-8040 as novel stem cell mobilization ...
Breaking Medicine Technology: