Navigation Links
NPs-NPR-B/pGC-cGMP signal pathway is involved in diabetic gastroparesis
Date:5/13/2009

The natriuretic peptide (NP) receptor type B (NPR-B) gene was expressed in gastric smooth muscles of normal and diabetic rats and the expression was increased in diabetic rats. These results suggest that natriuretic peptide-dependent pGC-cGMP signal is up-regulated and it may contribute to diabetic gastroparesis in STZ-induced diabetic rat.

Gastroparesis (delayed gastric emptying) is frequent in diabetic patients. It is a well-recognized complication of long-standing diabetes. Symptoms of diabetic gastropathy can range from mild dyspepsia to recurrent vomiting and abdominal pain and may progress to irreversible end-stage gastric failure known as gastroparesis. Gastroparesis seriously affects the quality of life. There is deterioration in glycemic control and incapacitating symptoms such as malnutrition, water and electrolyte imbalance, and aspiration may occur. However, the pathophysiology of diabetic gastropathy and gastroparesis, including impaired fundic and pyloric relaxation and impaired electrical pacemaking, is still not delineated.

A research article to be published in volume 15, May 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Zheng Lin from Department of Physiology, Yanbian University College of Medicine, used physiological, radioimmunoassy and histochemistry techniques to study the role of the NPs-NPR-B/pGC(particulate guanylate cyclase)-cGMP signal pathway in the pathophysiology of diabetic gastropathy and gastroparesis in streptozotocin (STZ)-induced diabetic rats.

This study has indicated that the CNP-induced relaxation and the production of cGMP of gastric smooth muscle were potentiated in STZ-induced diabetic rats. In addition to the activity of pGC, the expression of NPR-B mRNA in gastric smooth muscle was up-regulated in diabetic rats. These results suggest that the CNP-(NPR-B)-pGC-cGMP signal pathway may be involved in the pathogenesis of diabetic gastroparesis.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Signalife to Deploy Fidelity 100 Heart Monitors for AFL
2. Knee Pain May Signal Lung Cancer
3. Emory researchers identify signaling protein for multiple myeloma
4. Falling Platelet Counts May Signal HIV-Linked Dementia
5. Brown researchers make major signal transduction discovery
6. Cooper Clinic at Craig Ranch Opens Signaling the Next Phase of CooperLife Health-Focused Residential Community in McKinney
7. How Early Can We Detect Cardiovascular Disease Less Expensively... Even in Childhood? PAT is the Invisible Signal
8. Mitochondria send death signal to cardiac cells, study shows
9. 2-in-1 Test Signals Risk After Heart Attack
10. Lack of Strong Thirst Signals Leads Elderly to Drink Too Little
11. Signalife Establishes Signalcare Division
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... ... appointment of Mike Finnegan to the position of Executive Vice President, Sales and ... in healthcare technology, telehealth and medical device sales leadership. He has received industry ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... many of the health care industry’s hospitals and provider groups, has announced that ... for select customers. Parasail Health is a San Francisco health-finance startup that has ...
(Date:6/27/2017)... ... June 27, 2017 , ... A January 18th article ... reach a staggering $6.81 billion by the year 2024 according to a new report. ... rate than those made from titanium. Los Angeles area clinic Beverly Hills Periodontics & ...
(Date:6/27/2017)... ... June 27, 2017 , ... Atmosera , ... Atmosera Managed Azure Services . The trusted, transparent, and secure solution for the ... growing customer base. Atmosera’s next generation services include integrated capabilities for public, private, ...
(Date:6/27/2017)... ... June 27, 2017 , ... Today, June 27th is ... PTSD. Yet less than 20% will receive adequate care due to lack of effective ... receive any care at all. And left untreated, veterans are at an increased risk ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... -- Exactly 50 years ago today, the Monterey Pop Festival opened ... the San Francisco "Summer of Love."  To celebrate the anniversary, ... in strategic market research portals that it will begin delivering ... Northern Light,s "Summer of Love (For Our Customers)."  ... ...
(Date:6/14/2017)... , June 14, 2017  In 2016, Embodied ... Startups pitch competition and came away with $25,000 ... is described by Forbes as "entering the life of ... Association as teaching "empathy to medical professionals in an ... was recently named a finalist for the Department of ...
(Date:6/11/2017)...  Eli Lilly and Company (NYSE: LLY ) ... of galcanezumab, an investigational treatment for the prevention of ... key secondary endpoints for galcanezumab compared to placebo at ... EVOLVE-2 and REGAIN) will be presented today at the ... Boston . "The detailed ...
Breaking Medicine Technology: