Navigation Links
NMR sheds new light on polymorphic forms in pharmaceutical compounds

Scientists at the University of Warwick have used state-of-the-art nuclear magnetic resonance (NMR) techniques to shed new light on how pharmaceutical molecules pack together in the solid state.

Researchers made use of the UK's largest solid-state NMR magnets, housed at the University of Warwick, to carry out the study in collaboration with Astra Zeneca and GlaxoSmithKline.

The analytical methods look directly at the hydrogen and nitrogen atoms that are at the heart of so-called hydrogen bonds which control how organic molecules self-assemble into different three-dimensional solid-state structures.

Professor Steven P. Brown from the Department of Physics at the University of Warwick said: "Screening polymorphic forms of active pharmaceutical ingredients is a key part of pharmaceutical development."

"The combination of high magnetic field and novel rf pulse methodologies are allowing us to look by NMR with high precision at the distinct intermolecular hydrogen bonding arrangements that help us understand why pharmaceutical molecules adopt different polymorphic forms."

"By using the University of Warwick's state-of-the-art facilities we are able to shed new light on this complex area."


Contact: Anna Blackaby
University of Warwick

Page: 1

Related medicine news :

1. Defective signaling pathway sheds light on cystic fibrosis
2. Genetic Research Sheds Light on Chronic Pain
3. Rare disease in Amish children sheds light on common neurological disorders
4. Study sheds light on deadly GI disease in infants born with complex congenital heart disease
5. Rat Study Sheds Light on Cocaine Addiction
6. Preclinical inquiry into 1 mutation sheds light on addiction and a birth defect
7. Study of cell division sheds light on special mechanism in egg cells
8. Penn study sheds light on how the brain shifts between sleep/awake states under anesthesia
9. CU-Boulder study sheds light on how our brains get tripped up when were anxious
10. Research Sheds Light on Why Autism Is More Prevalent in Boys
11. Study sheds light on aromatase inhibitor joint pain syndrome
Post Your Comments:
(Date:11/25/2015)... ... , ... Beddit® has launched a new Android app for use ... a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and makes ... by a proprietary algorithm. Beddit analyzes the data to provide an easy to understand ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... provide scholarships for people struggling with eating disorders as a result of the ... second annual event, held at Fox Run Golf Club in Eureka, will help ...
(Date:11/25/2015)... ... 2015 , ... Many people know of the common symptoms of low thyroid ... skin. But many people who find their cholesterol levels and weight are creeping up ... especially if they don’t have any of the other symptoms. , Thyroid hormone plays ...
(Date:11/24/2015)... ... 2015 , ... Genesis Chiropractic Software helps practice owners automate ... between the practice owner and the patient that automatically manages all five aspects ... Click here to learn more. , According to Dr. Brian ...
(Date:11/24/2015)... Dallas, Texas (PRWEB) , ... November 24, 2015 , ... ... of all charitable donations are made in the last five weeks of the year ... #GivingTuesday was created in 2012 to connect the nation’s charities with those individuals who ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 Research and Markets ( ) ... - Global Forecast to 2020" report to their ... for 37.21% of the total market share in 2014. ... region is projected to growth at the highest CAGR ... primarily to the fast growing water, industrial gas treatment, ...
(Date:11/24/2015)... 25, 2015 WuXi PharmaTech (Cayman) Inc. ("WuXi" ... open-access R&D capability and technology platform company serving the ... China and the ... extraordinary general meeting of shareholders held today, the Company,s ... and approve the previously announced agreement and plan of ...
(Date:11/24/2015)... N.C. , Nov. 24, 2015  In the ... projects in an effort to quickly uncover new insights, ... --> --> However, ... a market research project and ensure that all rules ... and industry standards. Another major barrier to efficiently launching ...
Breaking Medicine Technology: