Navigation Links
NMR sheds new light on polymorphic forms in pharmaceutical compounds
Date:3/7/2012

Scientists at the University of Warwick have used state-of-the-art nuclear magnetic resonance (NMR) techniques to shed new light on how pharmaceutical molecules pack together in the solid state.

Researchers made use of the UK's largest solid-state NMR magnets, housed at the University of Warwick, to carry out the study in collaboration with Astra Zeneca and GlaxoSmithKline.

The analytical methods look directly at the hydrogen and nitrogen atoms that are at the heart of so-called hydrogen bonds which control how organic molecules self-assemble into different three-dimensional solid-state structures.

Professor Steven P. Brown from the Department of Physics at the University of Warwick said: "Screening polymorphic forms of active pharmaceutical ingredients is a key part of pharmaceutical development."

"The combination of high magnetic field and novel rf pulse methodologies are allowing us to look by NMR with high precision at the distinct intermolecular hydrogen bonding arrangements that help us understand why pharmaceutical molecules adopt different polymorphic forms."

"By using the University of Warwick's state-of-the-art facilities we are able to shed new light on this complex area."


'/>"/>

Contact: Anna Blackaby
44-247-657-5910
University of Warwick
Source:Eurekalert

Page: 1

Related medicine news :

1. Defective signaling pathway sheds light on cystic fibrosis
2. Genetic Research Sheds Light on Chronic Pain
3. Rare disease in Amish children sheds light on common neurological disorders
4. Study sheds light on deadly GI disease in infants born with complex congenital heart disease
5. Rat Study Sheds Light on Cocaine Addiction
6. Preclinical inquiry into 1 mutation sheds light on addiction and a birth defect
7. Study of cell division sheds light on special mechanism in egg cells
8. Penn study sheds light on how the brain shifts between sleep/awake states under anesthesia
9. CU-Boulder study sheds light on how our brains get tripped up when were anxious
10. Research Sheds Light on Why Autism Is More Prevalent in Boys
11. Study sheds light on aromatase inhibitor joint pain syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important to take certain ... inventor from Austin, Texas, has identified a solution. , She developed a prototype for ... lighting. As such, it eliminates the need to turn on a light when taking ...
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
Breaking Medicine Technology: