Navigation Links
NMR sheds new light on polymorphic forms in pharmaceutical compounds
Date:3/7/2012

Scientists at the University of Warwick have used state-of-the-art nuclear magnetic resonance (NMR) techniques to shed new light on how pharmaceutical molecules pack together in the solid state.

Researchers made use of the UK's largest solid-state NMR magnets, housed at the University of Warwick, to carry out the study in collaboration with Astra Zeneca and GlaxoSmithKline.

The analytical methods look directly at the hydrogen and nitrogen atoms that are at the heart of so-called hydrogen bonds which control how organic molecules self-assemble into different three-dimensional solid-state structures.

Professor Steven P. Brown from the Department of Physics at the University of Warwick said: "Screening polymorphic forms of active pharmaceutical ingredients is a key part of pharmaceutical development."

"The combination of high magnetic field and novel rf pulse methodologies are allowing us to look by NMR with high precision at the distinct intermolecular hydrogen bonding arrangements that help us understand why pharmaceutical molecules adopt different polymorphic forms."

"By using the University of Warwick's state-of-the-art facilities we are able to shed new light on this complex area."


'/>"/>

Contact: Anna Blackaby
44-247-657-5910
University of Warwick
Source:Eurekalert

Page: 1

Related medicine news :

1. Defective signaling pathway sheds light on cystic fibrosis
2. Genetic Research Sheds Light on Chronic Pain
3. Rare disease in Amish children sheds light on common neurological disorders
4. Study sheds light on deadly GI disease in infants born with complex congenital heart disease
5. Rat Study Sheds Light on Cocaine Addiction
6. Preclinical inquiry into 1 mutation sheds light on addiction and a birth defect
7. Study of cell division sheds light on special mechanism in egg cells
8. Penn study sheds light on how the brain shifts between sleep/awake states under anesthesia
9. CU-Boulder study sheds light on how our brains get tripped up when were anxious
10. Research Sheds Light on Why Autism Is More Prevalent in Boys
11. Study sheds light on aromatase inhibitor joint pain syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... 2016 The vast majority of dialysis patients ... Treatments are usually 3 times a week, with treatment ... travel time, equipment preparation and wait time.  This regimen ... for patients who are elderly and frail.  Many elderly ... rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: