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NKTR-105 Demonstrates Superior Antitumor Activity and Improved Pharmacokinetics Over Docetaxel in Preclinical Studies Presented at AACR
Date:4/22/2009

DENVER and SAN CARLOS, Calif., April 22 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR) presented data today at the American Association for Cancer Research (AACR) 100th Annual Meeting demonstrating that NKTR-105, a novel PEGylated form of docetaxel, has superior antitumor activity, as well as greater and sustained exposure in plasma and tumor tissue, over docetaxel in preclinical models.

In a comparative study of NKTR-105 and docetaxel, NKTR-105 treatment significantly delayed tumor growth as compared to docetaxel (122% v. 48%), which was associated with greater and sustained tumor exposure to docetaxel after NKTR-105 administration. Treatment with NKTR-105 increased docetaxel concentrations in tumors (0.4 to 4-fold higher) and resulted in an improved time-concentration profile (2-fold greater) as compared to docetaxel in a non-small cell lung (H460) mouse xenograft model.

"The encouraging antitumor activity and unique pharmacokinetic profile of NKTR-105 in these data support our ongoing Phase 1 study in patients with refractory solid cancers," said Randall Moreadith, M.D., Ph.D. Senior Vice President, Drug Development and Chief Development Officer. "We believe NKTR-105 has the potential to offer improved efficacy as well as improved safety and tolerability due to its prolonged half-life and increased uptake by tumor tissue relative to docetaxel. We are excited about the drug's potential to significantly expand therapeutic options for oncologists and patients."

In previous preclinical studies, NKTR-105 demonstrated superior antitumor activity with no neutropenia in multiple tumor models, indicating that NKTR-105 may enable sustained therapeutic levels of docetaxel without the myelosuppression that is a dose-limiting toxicity for this widely-used cancer therapy.

NKTR-105 is currently
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SOURCE Nektar Therapeutics
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