Navigation Links
NIST, NCI, SAIC partner on new method for detecting HER2 breast cancer
Date:2/19/2008

Generations of mothers have served up chicken soup to remedy the common cold, but now the therapeutic fowl may find use in diagnosis as well. Researchers at the National Institute of Standards and Technology (NIST), the National Cancer Institute (NCI) and the scientific research firm SAIC recently showed how chicken antibodies may one day improve the detection of an aggressive form of breast cancer.

HER2 is one of a family of genes that help regulate the growth and proliferation of human cells. Normal cells have two copies of HER2, but about 20 to 25 percent of breast cancers have multiple copies of the gene, resulting in the overproduction of a HER2-encoded protein (called HER2) that stimulates tumors to be particularly fast growing and difficult to treat in a subset of breast cancer patients.

Patients with that form of breast cancerabout 40,000 women in the United States annuallycan be treated with a monoclonal antibody called trastuzumab that targets and inhibits the growth of tumor cells with higher-than-normal levels of the HER2 protein. But because the treatment can have adverse side effects, its important to screen for those patients who would benefit from it by testing them for one or both of the two relevant biomarkers: the amplified HER2 gene or its overexpressed HER2 protein. Unfortunately, the existing tests for these biomarkers can yield a significant number of false positivesas many as 23 percent of patients in one 2006 clinical studyresulting in some women getting a somewhat risky and expensive treatment that cant help them.

In a paper in the International Journal of Cancer,* the NIST-NCI-SAIC research team found that chicken immunoglobulin Y (IgY) antibody created against the HER2 protein could be tagged with quantum dot (tiny, intense and tunable sources of colorful light) to more reliably detect the HER2 biomarker than the existing diagnostic tests using mammalian antibodies tagged with conventional fluorescent dyes. Overall, the improvement in sensitivity to the HER2 biomarker was about 40-50 percent.

The increased sensitivity of the HER2 quantum dot-based quantitative bioimaging system stems from the broad genetic differences between avian and human species. The chicken IgY antibody to HER2 reacts strongly with the target protein while ignoring other human proteins that can interfere with current diagnostic tests.

Other advantages of the novel NIST-NCI-SAIC system include faster and larger-scale production of the antibodies and a more reliable quantitative measure of HER2 biomarker level, in part because the quantum dot tags will stay bright and detectable while fluorescent dyes fade over time.


'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related medicine news :

1. 24 Hour Fitness Partners With Derek Jeter to Launch Signature Sports Clubs in New York City
2. The Leukemia & Lymphoma Society and the Nations Triathlon Announce New Partnership
3. WeissComm Partners Names Tom Jones Managing Director to Deepen Global Product Communications Offering
4. Paine & Partners, LLC Announces Sale of Byram Healthcare to OPG Groep N.V.
5. Lieff Cabraser Heimann & Bernstein, LLP Announces Class Action Lawsuits Have Been Filed Against American Dental Partners, Inc.
6. CryoCor to Present at Roth Capital Partners 20th Annual OC Growth Stock Conference
7. Boston Scientific Completes Sale of Fluid Management and Venous Access Businesses to Avista Capital Partners
8. DATATRAK to Present at the Roth Capital Partners 20th Annual Orange County Stock Conference
9. Michigan-Based Businesses Partner to Increase Dental Coverage Access for Medicare Beneficiaries
10. AIDS Healthcare Foundation and NCHADS Partnership Adds 8th Cambodian AIDS Treatment Center in Kirivong
11. Matrixx Initiatives, Inc. to Present at the Roth Capital Partners 20th Annual OC Growth Stock Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIST, NCI, SAIC partner on new method for detecting HER2 breast cancer
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... through a world of exterior design possibilities. CertainTeed, North America’s leading brand of ... by expanding the product offerings showcased in the mobile version of the ColorView® ...
(Date:2/12/2016)... SAN LUIS OBISPO, Calif. (PRWEB) , ... February 12, 2016 , ... The Central Coast ... purpose of this dance is to provide a night of fun for teens with and ... to help everyone feel welcomed and included at the event. The dance will take place ...
(Date:2/12/2016)... ... February 12, 2016 , ... Planet Future is a Final Cut ... are great for showcasing pictures, videos as well as text in an exciting cartoon ... thirds, transitions and a beautiful frame overlay. Pixel Film Studios makes editing easy; simply ...
(Date:2/11/2016)... ... February 11, 2016 , ... “ HEALING MIND : Five Steps to ... (published by Balboa Press) teaches readers how to become their own therapist. Providing a ... Janice McDermott, M.Ed., LCSW, offers an understanding of how to heal one’s inner child ...
(Date:2/11/2016)... Whippany, New Jersey (PRWEB) , ... February 11, 2016 , ... ... invited to a free CEU seminar titled, “Stroke Management: Time to Act, Time to ... Senior Housing Community in Whippany, N.J. The presenter is Vishal Chedda, president of ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016  Governor Andrew M. Cuomo today announced a ... throughout Western New York . This ... Polytechnic Institute, includes a major expansion of Athenex,s North ... Buffalo , as well as the creation of ... Dunkirk . The combined projects are expected ...
(Date:2/11/2016)... 11, 2016  MiMedx Group, Inc. (NASDAQ: MDXG ... membrane and other birth tissues, human skin and bone, ... market advanced products and therapies, announced today that it ... Healthcare Conference in New York , ... Michael J. Senken , Chief Financial Officer and ...
(Date:2/11/2016)... tracker, ALEX , has taken Kickstarter by storm, crowdfunding over $60,000 – or 120% of its ... said to be delivered to backers starting May of this year. ... ... ... Created by NAMU, a team of biomedical engineers out of ...
Breaking Medicine Technology: