Navigation Links
NIST, NCI, SAIC partner on new method for detecting HER2 breast cancer

Generations of mothers have served up chicken soup to remedy the common cold, but now the therapeutic fowl may find use in diagnosis as well. Researchers at the National Institute of Standards and Technology (NIST), the National Cancer Institute (NCI) and the scientific research firm SAIC recently showed how chicken antibodies may one day improve the detection of an aggressive form of breast cancer.

HER2 is one of a family of genes that help regulate the growth and proliferation of human cells. Normal cells have two copies of HER2, but about 20 to 25 percent of breast cancers have multiple copies of the gene, resulting in the overproduction of a HER2-encoded protein (called HER2) that stimulates tumors to be particularly fast growing and difficult to treat in a subset of breast cancer patients.

Patients with that form of breast cancerabout 40,000 women in the United States annuallycan be treated with a monoclonal antibody called trastuzumab that targets and inhibits the growth of tumor cells with higher-than-normal levels of the HER2 protein. But because the treatment can have adverse side effects, its important to screen for those patients who would benefit from it by testing them for one or both of the two relevant biomarkers: the amplified HER2 gene or its overexpressed HER2 protein. Unfortunately, the existing tests for these biomarkers can yield a significant number of false positivesas many as 23 percent of patients in one 2006 clinical studyresulting in some women getting a somewhat risky and expensive treatment that cant help them.

In a paper in the International Journal of Cancer,* the NIST-NCI-SAIC research team found that chicken immunoglobulin Y (IgY) antibody created against the HER2 protein could be tagged with quantum dot (tiny, intense and tunable sources of colorful light) to more reliably detect the HER2 biomarker than the existing diagnostic tests using mammalian antibodies tagged with conventional fluorescent dyes. Overall, the improvement in sensitivity to the HER2 biomarker was about 40-50 percent.

The increased sensitivity of the HER2 quantum dot-based quantitative bioimaging system stems from the broad genetic differences between avian and human species. The chicken IgY antibody to HER2 reacts strongly with the target protein while ignoring other human proteins that can interfere with current diagnostic tests.

Other advantages of the novel NIST-NCI-SAIC system include faster and larger-scale production of the antibodies and a more reliable quantitative measure of HER2 biomarker level, in part because the quantum dot tags will stay bright and detectable while fluorescent dyes fade over time.


Contact: Michael E. Newman
National Institute of Standards and Technology (NIST)

Related medicine news :

1. 24 Hour Fitness Partners With Derek Jeter to Launch Signature Sports Clubs in New York City
2. The Leukemia & Lymphoma Society and the Nations Triathlon Announce New Partnership
3. WeissComm Partners Names Tom Jones Managing Director to Deepen Global Product Communications Offering
4. Paine & Partners, LLC Announces Sale of Byram Healthcare to OPG Groep N.V.
5. Lieff Cabraser Heimann & Bernstein, LLP Announces Class Action Lawsuits Have Been Filed Against American Dental Partners, Inc.
6. CryoCor to Present at Roth Capital Partners 20th Annual OC Growth Stock Conference
7. Boston Scientific Completes Sale of Fluid Management and Venous Access Businesses to Avista Capital Partners
8. DATATRAK to Present at the Roth Capital Partners 20th Annual Orange County Stock Conference
9. Michigan-Based Businesses Partner to Increase Dental Coverage Access for Medicare Beneficiaries
10. AIDS Healthcare Foundation and NCHADS Partnership Adds 8th Cambodian AIDS Treatment Center in Kirivong
11. Matrixx Initiatives, Inc. to Present at the Roth Capital Partners 20th Annual OC Growth Stock Conference
Post Your Comments:
Related Image:
NIST, NCI, SAIC partner on new method for detecting HER2 breast cancer
(Date:10/13/2015)... ... October 13, 2015 , ... The American Institutes for Research ( AIR ) ... for students who have experienced sexual assault and other trauma. The toolkit, funded by ... the Violence Against Women Act's 21st anniversary. , AIR developed the ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... enterprise focused on cancer patients, today announced a new partnership with the ... battling this rare type of non-Hodgkin’s lymphoma, their families and physicians. , ...
(Date:10/13/2015)... ... October 13, 2015 , ... PhyMed ... services, today announced its partnership with WPC Healthcare , a provider of ... and organizes the data into an aggregated data repository necessary to perform reporting ...
(Date:10/13/2015)... ... 2015 , ... ProText Kinetic Panel is a typography creation tool made for ... create energetic text animations in any layout without the use of keyframes. Using ProText ... and stylize the text. With intuitive on-screen controls, users can re-position and scale the ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... software products, introduced a new company, RightSensor™ LLC, an Internet of Things (IoT) ... RightSensor™ provides a fully-managed approach for customers requiring sensor hardware for critical ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... DALLAS , Oct. 13, 2015   Generational ... privately-held, middle-market businesses, is pleased to announce the acquisition ... headquartered in Largo, Florida , by ... closed on September 11, 2015. ... . --> Florida . To ...
(Date:10/13/2015)... 13, 2015 According to the ... sponsored by Cardinal Health , achieving both ... diversified pharmacy revenue streams are vital to the ... NCPA Digest affirms that independent community ... in underserved inner city and rural areas," said ...
(Date:10/13/2015)... -- Data Science Automation (DSA), a system integration and automation engineering ... in the United Kingdom (UK) as ... . The decision to open the new office comes ... customers in the medical device industry throughout the UK. ... have had tremendous success over the last several years in ...
Breaking Medicine Technology: