Navigation Links
NIH to test maraviroc-based drug regimens for HIV prevention
Date:7/18/2012

Scientists are launching the first clinical trial to test whether drug regimens containing maraviroc, a medication currently approved to treat HIV infection, are also safe and tolerable when taken once daily by HIV-uninfected individuals at increased risk for acquiring HIV infection. The eventual goal is to see if the drug regimens can reduce the risk of infection.

The trial involves a strategy known as pre-exposure prophylaxis, or PrEP, in which HIV-uninfected individuals who are at risk for contracting the virus take one or two HIV drugs routinely in an effort to prevent infection. Called Novel Exploration of Therapeutics for PrEP, or NEXT-PrEP, the two-year study is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

"The NEXT-PrEP study will examine whether maraviroc-based PrEP is safe and well-tolerated. It is a necessary first step before we can test the effectiveness of maraviroc-based PrEP, and in the future, potentially expand the selection of drugs that may be used in this emerging HIV prevention strategy," said NIAID Director Anthony S. Fauci, M.D.

Led by principal investigator Roy M. Gulick, M.D., M.P.H., chief of the Division of Infectious Diseases and professor of medicine at Weill Cornell Medical College of Cornell University, the study team will enroll 400 HIV-uninfected men who have sex with men (MSM) ages 18 and older in 12 cities in the United States and Puerto Rico. The volunteers will be assigned at random to take one of the following four PrEP study regimens daily for 48 weeks:

Maraviroc (300 milligrams)
Maraviroc (300 milligrams) plus emtricitabine (200 milligrams)
Maraviroc (300 milligrams) plus tenofovir disoproxil fumarate (300 milligrams)
Emtricitabine (200 milligrams) plus tenofovir disoproxil fumarate (300 milligrams)

Placebo pills will be added to the regimens as needed so tha
'/>"/>

Contact: Laura Sivitz Leifman
sivitzl@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UW study plays pivotal role in todays FDA approval of HIV prevention drug
2. Studies Show Value of AIDS Drugs as Prevention
3. Identifying risky behaviors: The key to HIV prevention
4. Prevention is better than cure for killer cardiovascular disease
5. Tufts Medical Center researchers receive $10 million NIH grant to test blood clot prevention drug
6. The prevention of hereditary breast and ovarian cancer by PGD is feasible
7. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
8. Researchers call for obesity prevention efforts to focus on community-wide systems
9. HIV prevention measures must include behavioral strategies to work, says APA
10. New guidelines deliver concise messages for implementing cardiovascular prevention
11. Better health in adulthood starts with early prevention in childhood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... November 24, 2014 Global electrophysiology ... billion by 2020, according to a new study ... of cardiac arrhythmias clubbed with growing global geriatric ... market. Though still in the budding stage, the ... in usage rates in the recent times, with ...
(Date:11/24/2014)... Residents of retirement communities in Ohio ... SENIORS GOT TALENT, an annual online talent competition and ... to classic crooners, to seniors partying on a “night ... indeed living young. , “SENIORS GOT TALENT, while still ... prize, has always been about highlighting the vibrancy of ...
(Date:11/24/2014)... The Holiday Inn Westbury - Long ... Children's Association to donate various items consisting of ... other such items.The Association's program is aimed toward helping ... in nursing homes, assisted living facilities and nursing homes. ... being of seniors throughout the Long Island area. The ...
(Date:11/24/2014)... CA (PRWEB) November 24, 2014 SafeHandles™ ... episode of Innovations with Ed Begley Jr, airing via ... was created to provide a passive, non-invasive, replaceable, and ... how SafeHandles™ incorporates custom-fit shrinkable sleeves and adhesives to ... , “At the core of SafeHandles is the ...
(Date:11/24/2014)... PA (PRWEB) November 24, 2014 "My ... he was trying to cross the street in his ... driver never saw him. I came up with this ... visible at night." , He developed the Safety Lites ... or in low-lighting conditions. The device ensures that motorists ...
Breaking Medicine News(10 mins):Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 2Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 3Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 4Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 2Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 3Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 2Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 3Health News:New Episode of Innovations TV Series to Feature SafeHandles™ 2
... Therapeutic Focus Through ... Extending the Good Baby Product Line, ... (Nasdaq: BJGP; "BMP Sunstone"; the "Company") today,announced that its ... a non-binding letter of,intent to acquire 75 percent of ...
... babies born with hearing loss, experts note , , FRIDAY, July ... that all newborns be screened for congenital hearing loss. , ... infant,s health care evaluation," U.S. Preventive Services Task Force Chairman ... Colorado Department of Public Health and Environment, said in a ...
... is a Patient Education System that provides hospitals, medical centers and ... accessible using a telephone, pillow speaker, interactive touch screen or computer. ... ... Synergy Broadcast Systems recently launched several new interface options to it's ...
... Ky., July 17 William F. McMurry, a,Nationally ... obtained today final Court approval of a settlement ... by a Kentucky state court,judge. The settlement gives ... of deferred annuities. The Settlement is valued at ...
... Governor,Schwarzenegger and regulators announced a company-friendly settlement ... new lawsuit filed by the Los Angeles,City Attorney ... retroactively,canceling policies when patients got sick. Today,s settlement ... $5 million penalty., "The timing of today,s ...
... GlycoMark(R) Blood Test Now Established to Provide Physicians with Vital ... ... Patients with Diabetes, NEW YORK and WINSTON-SALEM, N.C., July ... Co., Ltd. (Tokyo, Japan),announced today the formation of a new joint ...
Cached Medicine News:Health News:BMP Sunstone Signs Letter of Intent to Acquire Shengda Pharmaceutical Co. 2Health News:BMP Sunstone Signs Letter of Intent to Acquire Shengda Pharmaceutical Co. 3Health News:All Newborns Should Have Ears Screened, Task Force Says 2Health News:Synergy Broadcast Systems Announces Enhancements to MMDS Patient Education System 2Health News:Synergy Broadcast Systems Announces Enhancements to MMDS Patient Education System 3Health News:William F. McMurry - Lead Class Counsel Obtains $16.4 Million Settlement for Elderly Clients 2Health News:Toyota Tsusho America, Inc. and Nippon Kayaku Co., Ltd. Announce the Formation of GlycoMark, Inc., a Joint Venture to Develop and Commercialize Novel Biomarkers for Diabetes 2Health News:Toyota Tsusho America, Inc. and Nippon Kayaku Co., Ltd. Announce the Formation of GlycoMark, Inc., a Joint Venture to Develop and Commercialize Novel Biomarkers for Diabetes 3
(Date:11/24/2014)... 2014 Luoxis Diagnostics, Inc., a subsidiary ... announced the presentation of three clinical and preclinical ... broadly applicable and robust research tool capable of ... response to injury, illness, or stress.  In all ... Luoxis, academic and pharmaceutical research partners, RedoxSYS was ...
(Date:11/24/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company developing ... today that Sergio Traversa , chief executive officer, ... Event" Micro-Cap Growth Conference on Wednesday, December 3, 2014.  ... Bel Air Hotel, which is located at 11461 Sunset ... The presentation is scheduled for 8:30 a.m. ...
(Date:11/24/2014)... , Nov. 24, 2014  AiCure, an ... motion-sensing technology to monitor medication ingestion, has announced ... monitor and intervene with patients receiving medication as ... Fatal overdoses from prescription opiates have quadrupled in ... deaths per year than heroin, cocaine and benzodiazepines ...
Breaking Medicine Technology:Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 2Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 3Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 4Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 5Relmada Therapeutics To Present At LD MICRO Conference 2Can artificial intelligence solve the $55 billion problem of opioid abuse? 2
... MALVERN, Pa., Nov. 17, 2010 Siemens ... System is now commercially available in the United ... diagnostic mammography, stereotactic biopsy, and upgrade capability to ... (Logo: http://photos.prnewswire.com/prnh/20070904/SIEMENSLOGO ) ...
... The National Community Pharmacists Association (NCPA) ... to unite to host what the organizers are calling ... the eastern Suffolk area of New York. ... ) According to event organizer and NCPA ...
Cached Medicine Technology:Siemens MAMMOMAT Inspiration Digital Mammography Commercially Available in U.S. 2Siemens MAMMOMAT Inspiration Digital Mammography Commercially Available in U.S. 3NCPA Commends Prescription Drug Take Back Event Hosted by 15 New York Pharmacies 2NCPA Commends Prescription Drug Take Back Event Hosted by 15 New York Pharmacies 3
50L...
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
Medicine Products: