Navigation Links
NIH to test maraviroc-based drug regimens for HIV prevention
Date:7/18/2012

Scientists are launching the first clinical trial to test whether drug regimens containing maraviroc, a medication currently approved to treat HIV infection, are also safe and tolerable when taken once daily by HIV-uninfected individuals at increased risk for acquiring HIV infection. The eventual goal is to see if the drug regimens can reduce the risk of infection.

The trial involves a strategy known as pre-exposure prophylaxis, or PrEP, in which HIV-uninfected individuals who are at risk for contracting the virus take one or two HIV drugs routinely in an effort to prevent infection. Called Novel Exploration of Therapeutics for PrEP, or NEXT-PrEP, the two-year study is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

"The NEXT-PrEP study will examine whether maraviroc-based PrEP is safe and well-tolerated. It is a necessary first step before we can test the effectiveness of maraviroc-based PrEP, and in the future, potentially expand the selection of drugs that may be used in this emerging HIV prevention strategy," said NIAID Director Anthony S. Fauci, M.D.

Led by principal investigator Roy M. Gulick, M.D., M.P.H., chief of the Division of Infectious Diseases and professor of medicine at Weill Cornell Medical College of Cornell University, the study team will enroll 400 HIV-uninfected men who have sex with men (MSM) ages 18 and older in 12 cities in the United States and Puerto Rico. The volunteers will be assigned at random to take one of the following four PrEP study regimens daily for 48 weeks:

Maraviroc (300 milligrams)
Maraviroc (300 milligrams) plus emtricitabine (200 milligrams)
Maraviroc (300 milligrams) plus tenofovir disoproxil fumarate (300 milligrams)
Emtricitabine (200 milligrams) plus tenofovir disoproxil fumarate (300 milligrams)

Placebo pills will be added to the regimens as needed so tha
'/>"/>

Contact: Laura Sivitz Leifman
sivitzl@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UW study plays pivotal role in todays FDA approval of HIV prevention drug
2. Studies Show Value of AIDS Drugs as Prevention
3. Identifying risky behaviors: The key to HIV prevention
4. Prevention is better than cure for killer cardiovascular disease
5. Tufts Medical Center researchers receive $10 million NIH grant to test blood clot prevention drug
6. The prevention of hereditary breast and ovarian cancer by PGD is feasible
7. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
8. Researchers call for obesity prevention efforts to focus on community-wide systems
9. HIV prevention measures must include behavioral strategies to work, says APA
10. New guidelines deliver concise messages for implementing cardiovascular prevention
11. Better health in adulthood starts with early prevention in childhood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... Kathleen Doheny HealthDay Reporter ... spouse may be linked to multiple health issues, but dementia ... For certain seniors, widowhood may even delay dementia, the researchers ... losing the spouse was associated with a later age of ... study researcher Dr. Bryan Woodruff. Woodruff, an assistant ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 ... celebrating its Grand Opening on Monday, July 14th, ... 06830. The celebration will last all week through ... new patients. Everyone is welcomed to attend. The ... who provides physician-administered skincare, anti-aging, weight loss services, ...
(Date:7/14/2014)... July 14, 2014 Many people are ... undergo plastic surgery to reduce a “double chin.” ... eliminates the need to go under the knife. Jawflex ... the jaw muscles, therefore tightening the skin in that ... , Jawflex is used for facial exercise, double chin ...
(Date:7/14/2014)... Tysons, VA (PRWEB) July 14, 2014 ... been a local icon to the Tysons Corner skyline ... Corner becoming its own municipality, known simply as “Tysons”, ... Sheraton Tysons Hotel. In addition to Tysons becoming ... Stations located in the heart of Tysons brings an ...
(Date:7/14/2014)... Kenn Renner recently released a new video describing ... describe the business on Austin Real Estate Investments . ... Kenn Renner – is internationally recognized for his combined expertise ... , Investing in real estate is a great way for ... their career, while others like to do it as a ...
Breaking Medicine News(10 mins):Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 2Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 3Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 3Health News:Jawflex | Double Chin Exercise for Double Chin Reduction 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 3Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 4
... women, especially, the brew could boost heart health, study finds ... coffee lovers: Drinking up to six cups a day of ... a new study shows. , In fact, coffee might even ... "Our results suggest that long-term, regular coffee consumption does not ...
... EDEN PRAIRIE, Minn., June 16 Through emotional ... Benatar and,Neil Giraldo helped the Starkey Hearing Foundation, ... a record $5,045,000 at its annual,"So the World ... at the,RiverCentre in Saint Paul, Minn. With money ...
... and pharmaceuticals were important to medicine in the 19th,& 20th ... century,and biofeedback is an important component of Behavioral Medicine, Dr. ... Basmajian, Member of the ... the World,s Leading Sport,Psychologists that trained Canada,s top Olympic athletes ...
... association between chilhood overweight and higher readings , , ... high blood pressure in childhood are also prone to ... 50 studies conducted over four decades in different countries. ... pressure tracks from childhood to adulthood and that elevated ...
... Jose, CA, June 11, 2008 ... the International Nursing Association for Clinical Simulation and ... Clinical Simulation in Nursing ( www.nursingsimulation.org ) beginning ... only journal provides information about the development and ...
... Mike,Leavitt today declared a public health emergency in ... gives HHS, Centers for Medicare &,Medicaid Services, (CMS) ... in meeting emergency health needs., "The flooding ... individual and,to their communities," Secretary Leavitt said. "This ...
Cached Medicine News:Health News:Coffee Drinkers Might Live Longer 2Health News:Coffee Drinkers Might Live Longer 3Health News:Garth Brooks, Jon McLaughlin, and Pat Benatar and Neil Giraldo Raise Their Voices to Help Starkey Hearing Foundation Raise More Than $5 Million at Annual Fundraiser 2Health News:Biofeedback Workshops & Distance Learning Offer Credits and Training Options 2Health News:High Blood Pressure in Kids Tracks Into Adulthood 2Health News:INACSL and Elsevier partner to publish Clinical Simulation in Nursing 2Health News:HHS Takes Action to Help Medicare Beneficiaries and Providers in Iowa and Indiana 2Health News:HHS Takes Action to Help Medicare Beneficiaries and Providers in Iowa and Indiana 3
(Date:7/11/2014)... 2014  Kindred Hospital Houston Northwest, with Wound ... of its new outpatient wound healing center.  The ... with chronic, hard to heal wounds. Chronic wounds ... amputation, lower leg wounds related to blood flow ... traumatic injury wounds which are complex and demonstrate ...
(Date:7/11/2014)... According to a new market ... (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - Global ... the global endoscopy devices market was valued at USD ... at a CAGR of 6.8% from 2013 to 2019, ... in 2019. Browse the full Endoscopy Devices Market ...
(Date:7/11/2014)... 11, 2014 Show ... & Health Expo 2014 were a brand ... London , plus a ...          (Logo: http://photos.prnewswire.com/prnh/20130723/629764-a) ... )      (Photo: http://photos.prnewswire.com/prnh/20140711/696892-b ...
Breaking Medicine Technology:Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4
... , ... (OTC Bulletin Board: HFGB), a leading developer and producer,of plant ... food production in Xi,an, China, today reported that in its,third ... Revenues for the quarter ended Sept. ...
... , NORTH HOLLYWOOD, Calif., Nov. ... a leading national hospitalist physician group practice company, announced today that ... ACP Hospitalist as one of the 2009 Top Ten Hospitalists ... of the magazine. , Dr. Vaidyan has been a practicing physician ...
Cached Medicine Technology:Huifeng Bio-Pharmaceutical Technology Reports 26% Quarterly Revenue Increase 2Huifeng Bio-Pharmaceutical Technology Reports 26% Quarterly Revenue Increase 3Huifeng Bio-Pharmaceutical Technology Reports 26% Quarterly Revenue Increase 4IPC The Hospitalist Company's Philip Vaidyan, M.D. Named a Top Hospitalist of 2009 2IPC The Hospitalist Company's Philip Vaidyan, M.D. Named a Top Hospitalist of 2009 3
... A surgically implanted bone growth stimulator ... EBI OsteoGen surgically implanted bone growth stimulator ... of nonunions when surgery is already planned ... concern. Because the OsteoGen is totally surgically ...
... contact between grant material and fracture ends ... bones., ,Grid-Like Format of Mesh Cathode Provides ... , ,The innovative Mesh Cathode of the ... and a scaffolding effect designed to increase ...
... Cystoscope System using EndoSheath Technology introduces ... urologists in both their hospitals and ... flexible cystoscope with the sterile, protective ... procedures, while minimizing the costs of ...
... Plasma-CISE™ (wire electrodes) and Plasma-CUT™ ... devices that produce precise, consistent ... spread and Vapor sealing of ... The devices provide excellent results ...
Medicine Products: