Navigation Links
NIH supports new research strategy for finding a cure for HIV

An international team led by researchers from the University of California, San Francisco and the nonprofit Vaccine and Gene Therapy Institute of Port St. Lucie, Fla., has received a major grant from the National Institutes of Health to develop a strategy to eradicate HIV from the body.

The team includes academic, industry and governmental scientists.

"Even though existing anti-HIV drugs have dramatically changed the course of HIV disease for many patients, particularly in Western/developed countries, the drugs are expensive and require daily dosing for life, they are not available to everyone who needs them, they have side effects and they do not fully restore health," said Steven Deeks, MD, a professor of medicine at the UCSF Division of HIV/AIDS at San Francisco General Hospital and one of the three principal investigators.

Moreover, he said, "HIV continues to kill millions of people in developing countries, including regions of Africa, Asia and Eastern Europe. Our hope is to have a single, or more likely, a combination regimen that truly cures the disease and that we could eventually deliver to people infected with HIV throughout the world."

The award will total over $4 million a year for five years, and consists of seven projects and three core programs. The research project has three broadly defined objectives. One is to define HIV's reservoirthe regions within organs such as the gut, lymph tissue and the brain where HIV remains dormant at low levels even when current combination antiretroviral therapy prevents further replication of the virus in the body. The second is to understand how this reservoir is created and maintained. The third is to test potential treatments.

"In order to develop a cure that would eradicate HIV/AIDS, we need to be able to first determine and understand all of the places and types of cells in the body where the HIV virus can hide or lie dormant, allowing it to persist in patients even after years of successful suppressive therapy. Then we can test treatments that target and eliminate these viral reservoirs without activating the rest of the immune system," said study co-principal investigator Rafick-Pierre Sekaly, PhD, co-director and chief scientific officer of the Vaccine and Gene Therapy Institute in Florida.

The National Institute of Allergy and Infectious Diseases (NIAID), part of NIH, is the primary funding organization and announced this award as one of its Martin Delaney Collaboratory grants that seek to advance progress towards a cure through public-private partnerships between government, industry and academia. NIAID is announcing three Collaboratory grants totaling over $14 million per year for up to five years. Co-funding is also provided by the National Institute of Mental Health.

"Marty Delaney, who died of liver cancer in 2009, was a friend of mine and a hero," said co-principal investigator, Joseph ("Mike") McCune, MD, PhD, chief of the UCSF Division of Experimental Medicine. "Starting in the darkest days of the epidemic, when he founded Project Inform, and throughout the next 25 years, he was one of the most influential and thoughtful leaders in the struggle against HIV, helping researchers to work together and spearheading efforts to get better therapies to patients. Unlocking the secret of how to cure HIV would be a fitting tribute to his legacy."

The research team includes collaborators from Johns Hopkins University, the Vaccine and Gene Therapy Institute at Oregon Health and Science University (OHSU), the Oregon National Primate Research Center at OHSU, the University of Minnesota, Monash University, the American Foundation for AIDS Research (amfAR), the Blood Systems Research Institute, the Karolinska Institute, the University of Miami, and the University of California, Davis. Merck Research Labs is the team's industry partner, although Merck will not be receiving any funding for its participation in the project.


Contact: Jeff Sheehy
University of California - San Francisco

Related medicine news :

1. NASBE Supports First Lady Michelle Obama in Fight Against Childhood Obesity
2. Study supports alternative anti-seizure medication following acute brain injury
3. Minnesota Chiropractic Association Supports Lawsuit Against BCBSA
4. JPMA Supports CPSC Chairman Tenenbaum's Continued Safety Efforts
5. AT&T Foundations $50,000 Donation to National Health Foundation Supports Teen Pregnancy Prevention Program
6. reco jeans Supports Children With Rare Diseases
7. ChildCare Education Institute Supports the First Ladys Efforts to Reduce Childhood Obesity
8. WellNet Supports HPM Institute Director in Calling for More Active Enterprise Involvement in Managing Healthcare Quality and Costs
9. James Scott Farrin Supports Radiothon for Duke Children's Hospital
10. MARC Coalition Supports Medicare Secondary Payer Enhancement Act (MSPEA)/H.R. 4796
11. Hot Tub Company Helps Swimmers Thaw and Supports Special Olympics
Post Your Comments:
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... for oncology and hematology continuing medical education (CME), today announced that the first ... Grand Hyatt New York. , “The prevention, detection and treatment of gastrointestinal cancers ...
(Date:12/1/2015)... ... December 01, 2015 , ... Speech and physical therapies ... with innovative technologies and under the right circumstances, these practices can be merged. ... a dual-approach to his or her therapeutic sessions, as well as gives the ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... 7th Annual 2015 Golden Bridge Business Awards under the New Products and Services ... capex web based sample management software that helps labs organize data ...
(Date:12/1/2015)... ... December 01, 2015 , ... The importance of volumetric breast ... focus of numerous abstracts accepted for presentation here, at the 101st Annual Radiology ... highlight the use of Volpara Solutions’ quantitative breast imaging software tools for providing ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... Health Center of Excellence (BHCOE) today announced that the organization has awarded Education ... San Francisco, with a Distinguished Award. The award celebrates exceptional special needs providers ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 1, 2015 --> ... Drugs Market by Type of Drug (Monoclonal Antibodies, Interferon-Alpha, Interleukins, ... and Pipeline Analysis - Global Forecast to 2020", published by ... USD 73,529.2 Million by 2020 from USD 40,281.6 Million in ... Browse 37 market data ...
(Date:12/1/2015)... Virginia , 1 de diciembre de ... en tecnología para cuchillas de precisión, develó ... programa de identidad de marca. El nuevo ... el diseño y la ingeniería de productos ... la diferencia". ...
(Date:12/1/2015)... , Dec. 1, 2015 During ... in San Francisco, CA , ... to the coronary marketplace. During a satellite symposium, ... Stent Design to Minimize Restenosis", a renowned physician ... available Medinol NIRxcell™ CoCr Coronary Stent System and ...
Breaking Medicine Technology: