Navigation Links
NIH-supported scientists investigate a newly emerging staph strain
Date:2/28/2012

Using genome sequencing and household surveillance, National Institutes of Health (NIH) scientists and their colleagues from Columbia University Medical Center and St. George's University of London have pieced together how a newly emerging type of Staphylococcus aureus bacteria has adapted to transmit more easily among humans. Their new study underscores the need for vigilance in surveillance of S. aureus.

A methicillin-resistant S. aureus (MRSA) strain known as livestock-associated (LA)-ST398 is a cause of severe infections in people in Europe who have close contact with swine, but the bacterium does not transmit well from person to person. More recently, a variant of LA-ST398 that presently is susceptible to methicillin has emerged as a significant cause of community-associated infections in several countries, including the United States, Canada and China. The new strain primarily infects the skin and soft tissue, but it can cause more severe disease.

Based on samples from 332 households in northern Manhattan, New York, scientists have determined that this new strain, named ST398-NM, efficiently transmits from person to personin contrast to the transmission characteristics of the livestock-associated strain.

By analyzing and comparing the genomes of LA-ST398 and ST398-NM, the study, led by Anne-Catrin Uhlemann, M.D., Ph.D., at Columbia, charted several ways in which the bacterium has adapted to its hosts. For example, they learned that the human-adapted strain (ST398-NM) contains human-specific immune evasion genes, whereas the livestock-adapted strain does not. They also found that ST398-NM adheres well to human skin, thus increasing its ability to colonize and infect people.

The study authors say it is possible that the ST398-NM strain emerging in northern Manhattan could acquire genes making it resistant to methicillin. Scientists at the NIH National Institute of Allergy and Infectious Diseases and their colleagues plan to continue global surveillance of ST398, paying close attention to its molecular adaptations. Their work promises to inform the development of new diagnostic and surveillance strategies against this emerging pathogen.

This study on the human-adapted variant of ST398 strain complements a study that a different group of scientists published in mBio on Feb. 21. That study, also supported by NIH, focused on the evolution of the ST398 strain in livestock, including the effect of antibiotic use. Lance Price, Ph.D., and Paul Keim, Ph.D., at the Translational Genomics Research Institute in Flagstaff, Ariz., led that study with colleagues from around the world.


'/>"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. CROI -- Day 3: Selected highlights of NIH-supported research
2. CROI -- Day 2: Selected highlights of NIH-supported research
3. NIH-supported finding on cocaine addiction: Tiny molecule, big promise
4. Scripps Florida scientists uncover inflammatory circuit that triggers breast cancer
5. UCLA scientists report link between traumatic brain injury, post-traumatic stress disorder
6. Scientists make strides toward fixing infant hearts
7. Scripps research scientists demonstrate effective new biopsy in a blood test to detect cancer
8. Scientists May Be Closer to Developing Red Wine Drug
9. Scientists Use Brain Waves to Eavesdrop on the Mind
10. Scripps research scientists illuminate cancer cells survival strategy
11. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... strategic partnership with Connance, a healthcare industry leader providing predictive analytics to ... technology combine to provide health systems, hospitals and ambulatory surgical centers with ...
(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in ... in honor of the city’s history as home to some of the world’s leading ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Consumers have ... and regulators/payers have placed more emphasis on patient ... patient support programs in the pharmaceutical industry have ... medications. Consequently, pharmaceutical companies are focusing on becoming ... are providing products and services that improve health. ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
Breaking Medicine Technology: