Navigation Links
NIH-supported scientists demonstrate very early formation of SIV reservoir


Scientists have generally believed that HIV and its monkey equivalent, SIV, gain a permanent foothold in the body very early after infection, making it difficult to completely eliminate the virus even after antiretroviral therapy has controlled it. Now NIH-supported researchers report that SIV can become entrenched in tissues fewer than 3 days after infection, before the virus is detectable in blood plasma (the liquid part) or blood cells.

Led by Dan H. Barouch, M.D., Ph.D., of Beth Israel Deaconess Medical Center and the Ragon Institute, in collaboration with the U.S. Military HIV Research Program, the scientists infected 20 monkeys with a high dose of SIV and divided them into five groups. Four groups received triple-drug antiretroviral therapy for 6 months starting at 3, 7, 10 or 14 days after infection. The fifth group was not treated. The scientists tested the monkeys for SIV in their blood and tissues and for anti-SIV immune responses, and confirmed that the drug regimen fully suppressed viral replication in all the treated animals.

During treatment, testing detected immune responses to SIV in the blood of all monkeys except those that started treatment 3 days post infection. SIV DNA was detectable in cells of the gut and lymph nodes in all of the monkeys, and in blood cells of all but the day 3-treated monkeys.

After 6 months, the scientists halted treatment and the virus again became detectable in the blood of all the monkeys.

Together, these findings indicate that starting therapy for SIV 3 days post infection blunted the development of virus in blood but did not prevent it from establishing a permanent reservoir in tissues, including cells of the gut and lymph nodes. These data show that an irreversible viral reservoir is established very early following SIV infection in this animal model, and that early antiretroviral therapy therefore has a limited effect on the SIV reservoir in this model.


Contact: Laura S. Leifman
NIH/National Institute of Allergy and Infectious Diseases

Related medicine news :

1. Toddler functionally cured of HIV infection, NIH-supported investigators report
2. NIH-supported researchers identify new class of malaria compounds
3. Scientists solving the mystery of human consciousness
4. Scientists uncover multiple faces of deadly breast cancer
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists tailor cell surface targeting system to hit organelle ZIP codes
7. Scientists rewrite rulebook on breast cancer in landmark global study
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with the ... 2016 Building Better Radiology Marketing Programs meeting will showcase some of ... 6, 2016, at Caesars Palace in Las Vegas with a pre-conference session on ...
(Date:11/27/2015)... ... 27, 2015 , ... The moment you stop improving is ... fulfilling the needs of advisers and clients but going above and beyond to ... customer service. However, there's always room for improvement, which is why the entire ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and women ... healthcare organizations in the country. They have overseen financial turnarounds, shown commitment to ... the healthcare industry as a whole through their advocacy and professional efforts. , ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., developer ... incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 product ... Q-Suite 5.10 up-to-date with a version of Asterisk that will receive not only ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... a real-time eReferral system for diagnostic imaging in the Waterloo region. Using the ... and Nuclear Medicine tests directly from their electronic medical record (EMR) without the ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... -- Research and Markets ( ) has announced ... by Type (Dressings, Therapy Devices, Active Wound Care), Application ... and Geography - Global Forecast to 2020" report ... --> The purpose of this report is ... global advanced wound care market. It involves deep dive ...
(Date:11/26/2015)... November 26, 2015 ... adds "Global Repaglinide Industry ... Report on China Repaglinide Market, 2010-2019" ... data and information to its online ... . --> ...
(Date:11/26/2015)... Research and Markets ( ) ... Future Horizons and Growth Strategies in the Italian ... Segment Forecasts, Competitive Intelligence, Emerging Opportunities" report ... --> This new 247-page report ... drug monitoring market, including emerging tests, technologies, instrumentation, ...
Breaking Medicine Technology: