Navigation Links
NIH-supported scientists demonstrate very early formation of SIV reservoir
Date:7/21/2014

WHAT:

Scientists have generally believed that HIV and its monkey equivalent, SIV, gain a permanent foothold in the body very early after infection, making it difficult to completely eliminate the virus even after antiretroviral therapy has controlled it. Now NIH-supported researchers report that SIV can become entrenched in tissues fewer than 3 days after infection, before the virus is detectable in blood plasma (the liquid part) or blood cells.

Led by Dan H. Barouch, M.D., Ph.D., of Beth Israel Deaconess Medical Center and the Ragon Institute, in collaboration with the U.S. Military HIV Research Program, the scientists infected 20 monkeys with a high dose of SIV and divided them into five groups. Four groups received triple-drug antiretroviral therapy for 6 months starting at 3, 7, 10 or 14 days after infection. The fifth group was not treated. The scientists tested the monkeys for SIV in their blood and tissues and for anti-SIV immune responses, and confirmed that the drug regimen fully suppressed viral replication in all the treated animals.

During treatment, testing detected immune responses to SIV in the blood of all monkeys except those that started treatment 3 days post infection. SIV DNA was detectable in cells of the gut and lymph nodes in all of the monkeys, and in blood cells of all but the day 3-treated monkeys.

After 6 months, the scientists halted treatment and the virus again became detectable in the blood of all the monkeys.

Together, these findings indicate that starting therapy for SIV 3 days post infection blunted the development of virus in blood but did not prevent it from establishing a permanent reservoir in tissues, including cells of the gut and lymph nodes. These data show that an irreversible viral reservoir is established very early following SIV infection in this animal model, and that early antiretroviral therapy therefore has a limited effect on the SIV reservoir in this model.


'/>"/>

Contact: Laura S. Leifman
laura.sivitz@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Toddler functionally cured of HIV infection, NIH-supported investigators report
2. NIH-supported researchers identify new class of malaria compounds
3. Scientists solving the mystery of human consciousness
4. Scientists uncover multiple faces of deadly breast cancer
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists tailor cell surface targeting system to hit organelle ZIP codes
7. Scientists rewrite rulebook on breast cancer in landmark global study
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... 11, 2016 , ... Atlantic Information Services, Inc. (AIS) is ... Case Study for Plans and Purchasers.” Executives from Intel Corp. and Providence Health ... value-based health benefits program Connected Care, will discuss the challenges they faced (and ...
(Date:2/11/2016)... Australia (PRWEB) , ... February 11, 2016 , ... ... potential ?" motivational speaker, trainer and author Ray Clarke poses a question as ... personal fulfillment . In his book, "Being in the Being" (published by Partridge ...
(Date:2/11/2016)... ... February 11, 2016 , ... Greenfield ... charity program created to assist the people of their local community. The agency ... organizations and community leaders. Their hope is to bring awareness to important local ...
(Date:2/11/2016)... ... 2016 , ... Talix today announced that Clive Fields, MD, ... at the 2016 HIMSS Annual Conference & Exhibition, taking place February 29 – ... Coding for Care: Using Data Analytics for Risk Adjustment ,” Dr. Fields will ...
(Date:2/11/2016)... , ... February 11, 2016 , ... The annual list ... on evaluation of DataPoint’s team dedication and commitment to the SharePoint ecosystem. ... the annual list. The panel’s goal is to recognize and promote technology entrepreneurship. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Transformational M&A achieved through NPS and Dyax acquisitions ... Transformational M&A achieved through NPS and Dyax acquisitions and the ... M&A achieved through NPS and Dyax acquisitions and the announced ... with most robust pipeline in Shire , s ... most robust pipeline in Shire , s history ...
(Date:2/11/2016)... CHICAGO, Ill. , Feb. 11, 2016 /PRNewswire/ ... of the AbbVie Rheumatology Scholarship, designed to provide ... rheumatologic disease as they pursue higher education goals. ... each for the 2016-2017 school year. The AbbVie ... Tracie Haas , vice president, corporate social ...
(Date:2/11/2016)... , Feb. 11, 2016 Exactus Pharmacy ... providing high-quality specialty pharmacy care for those suffering ... it has achieved full Specialty Pharmacy Accreditation from ... dedicated to promoting health care quality through accreditation, ... --> The URAC accreditation process demonstrates ...
Breaking Medicine Technology: