Navigation Links
NIH study offers hope to patients with nonalcoholic steatohepatitis
Date:4/28/2010

18 years and older were randomized to either receive 30 milligrams of Actos daily, 800 international units of a form of vitamin E (RRR-alpha-tocopherol) daily, or placebo for 96 weeks. Researchers reported that vitamin E and Actos helped certain patients with NASH.

After 96 weeks of treatment, vitamin E improved all features of NASH except the degree of cirrhosis in the liver. Forty-three percent of participants treated with vitamin E met the primary endpoint of the trial compared to only 19 percent of those who received a placebo. The primary endpoint was a composite of the scores for several features of NASH--retention of lipids, liver inflammation, and liver degeneration. The scores were used to assess disease activity.

While Actos improved liver inflammation and retention of lipids in 34 percent of individuals who received it, suggesting a benefit, the improvement fell short of being statistically significant. Actos also led to an undesirable weight gain of 10 pounds over the 96-week trial. There was an early improvement in liver enzyme tests among participants receiving either Actos or vitamin E. However, upon stopping the medications, the liver enzymes worsened again suggesting the need for long-term treatment.

While the PIVENS trial provides evidence that vitamin E benefits NASH patients, it is not a panacea, said Arun Sanyal, M.D., NASH CRN co-chair and PIVENS principal investigator and chair of gastroenterology at Virginia Commonwealth University in Richmond.

"This study was conducted in people who had NASH but did not have diabetes. The benefits of either treatment in NASH patients who have diabetes remain unknown," said Sanyal. "Also, the study lasted only two years and the potential long-term benefits and risks of taking vitamin E or Actos in these doses are still uncertain."

Researchers acknowledge that many participants receiving these treatments did not improve. To better understand response t
'/>"/>

Contact: Leslie Curtis
niddkmedia@mail.nih.gov
301-496-3583
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Twins Study Points to Environmental Cause for MS
2. Fibromyalgia affects mental health of those diagnosed and their spouses, study finds
3. Children's Rights Group Agrees with New Study: Infant Circumcision Causes 100 Deaths Each Year in US
4. Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
5. Study examines global availability of treatment involving transplantation of blood stem cells
6. Study finds that drugs used for treatment of influenza in pregnancy appear to be safe
7. Comparative-effectiveness study confirms new treatment for diabetic macular edema
8. CureTogether Announces Online Autism Treatment Study
9. LA BioMed awarded research grant to study HIV prevention gel
10. Study Makes Strides in Understanding Ovarian Cancer
11. Brown Rice Tied to Better Heart Health in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... New York (PRWEB) May 22, 2013 Jury ... nation’s first trial involving a da Vinci lawsuit, ... case, the family of a man who allegedly died of ... more than $8 million in damages from Intuitive Surgical, Inc. ... its physician training program for the da Vinci Surgical System ...
(Date:5/22/2013)... Reporter , , WEDNESDAY, May 22 (HealthDay News) -- Anyone ... is something about feet that fungi seem to like. ... the fungal groups that live on your skin -- ... It,s no secret that the human body is ... fungi, both outside and inside. And it,s mainly a ...
(Date:5/22/2013)... New York, New York (PRWEB) May 22, 2013 ... a metal-on-metal version of the DePuy Pinnacle Hip Replacement ... underway in Texas Federal Court, Bernstein Liebhard LLP reports. ... Court has directed DePuy Orthopaedics to produce monitoring reports ... government into the company’s medical device marketing practices. ...
(Date:5/22/2013)... Today, Zane Benefits, Inc. published a new ... Zane Benefits, which provides comprehensive and flexible alternatives to ... defined contribution plans and health reimbursement ... in 2014 as part of the Affordable Care Act ... will become available through new state health insurance exchanges. ...
(Date:5/22/2013)... may be reaping enormous income for patients whose ... contracted in their intensive care units. , In ... American Journal of Medical Quality , the ... an avoidable central line-associated bloodstream infection (CLABSI) costs ... a similar infection-free patient. Moreover, hospitals earn nearly ...
Breaking Medicine News(10 mins):Health News:Da Vinci Robot Lawsuits: Bernstein Liebhard LLP Notes Beginning of Jury Deliberations in Nation’s First Trial Involving Alleged Da Vinci Surgery Complications 2Health News:Da Vinci Robot Lawsuits: Bernstein Liebhard LLP Notes Beginning of Jury Deliberations in Nation’s First Trial Involving Alleged Da Vinci Surgery Complications 3Health News:Da Vinci Robot Lawsuits: Bernstein Liebhard LLP Notes Beginning of Jury Deliberations in Nation’s First Trial Involving Alleged Da Vinci Surgery Complications 4Health News:Scientists Map the Fungi on Your Feet 2Health News:Scientists Map the Fungi on Your Feet 3Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Notes New Order in Federal Pinnacle Litigation Requiring Production of Monitoring Reports from Federal Investigation 2Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Notes New Order in Federal Pinnacle Litigation Requiring Production of Monitoring Reports from Federal Investigation 3Health News:Zane Benefits Publishes New Information on Alabama Health Insurance Exchange 2Health News:Zane Benefits Publishes New Information on Alabama Health Insurance Exchange 3Health News:Hospitals profit when patients develop bloodstream infections 2Health News:Hospitals profit when patients develop bloodstream infections 3Health News:Hospitals profit when patients develop bloodstream infections 4
... Daniel D. Von Hoff, Physician-in-Chief for the Translational Genomics Research ... Society of Clinical Oncology (ASCO) for his cancer research. ... A. Karnofsky Memorial Award and Lecture at ASCO,s 46th Annual ... ASCO will present the award to Dr. Von Hoff "for ...
... B for those with scent-robbing viral infection, study found ... help people who lose their sense of smell after ... study, 15 patients with post-viral olfactory dysfunction (PVOD) had ... patients were compared with PVOD patients treated with vitamin ...
... can be lost, treatment can work again , THURSDAY, April ... which certain tumor cells that become resistant to cancer drugs ... lead to new ways to combat drug resistance in cancer ... April 1 in the journal Cell . , Although ...
... medicine specialists), subspecialists, medical students, and allied health ... Medicine 2010, the annual scientific meeting of the ... 24 (Thursday - Saturday), at the Toronto Convention ... devoted to adult medicine and is the second-largest ...
... promise for safely removing large brain tumors from an ... sinus cavities, clinical researchers at the Brain Tumor Center ... University Hospital have found. The findings, to be ... Journal of Neurosurgery and previously published online in ...
... of elderly patients. In many cases, a hip fracture is ... health, setting off a long list of potential complications. ... issue of The Journal of Bone and Joint Surgery ... by the American Society of Anesthesiologists (ASA)-is a leading indicator ...
Cached Medicine News:Health News:TGen Physician-In-Chief Dr. Daniel D. Von Hoff wins ASCO award 2Health News:Study Suggests How Some Cancers Resist Treatment 2Health News:Study Suggests How Some Cancers Resist Treatment 3Health News:All you need to know about adult medicine is at Internal Medicine 2010 2Health News:All you need to know about adult medicine is at Internal Medicine 2010 3Health News:All you need to know about adult medicine is at Internal Medicine 2010 4Health News:All you need to know about adult medicine is at Internal Medicine 2010 5Health News:All you need to know about adult medicine is at Internal Medicine 2010 6Health News:Researchers quantify benefits of minimally invasive removal of hard-to-reach tumors 2Health News:Researchers quantify benefits of minimally invasive removal of hard-to-reach tumors 3Health News:Hip surgery success partially predicted by number of other existing conditions 2
(Date:5/22/2013)... , May 22, 2013   Life Line Screening ... services announced today the creation of a unique partnership ... MCM is a population health management ... growing list of clients. These important expanded services will ... conditions earlier. Effective prevention reduces cost of care when ...
(Date:5/22/2013)... , 22. Mai 2013  Grifols, ein ... Barcelona , Spanien, präsentierte ... eine höhere Dosis von PROLASTIN©-C (Alpha1-Proteinasehemmer [human]) ... Alpha1-Antitrypsinmangel (AAT) auf ein Niveau anhebt, das ... Bereichs liegt. ATT-Mangel ist eine lebensbedrohliche, genetische ...
(Date:5/22/2013)... CITY , May 22, 2013 ... today announced it received 510(k) clearance from the ... diagnostic X-ray image processing workstation that combines radio ... one platform.  Varian,s Nexus DRF Digital X-Ray Imaging ... variety of image receptors, including CCD cameras and ...
Breaking Medicine Technology:Life Line Screening and MCM Solutions for Better Health Announce New Partnership 2Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 2Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 3Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 4Varian Medical Systems Receives FDA 510(k) Clearance of its Nexus DRF Digital X-Ray Imaging System 2
... In a randomized, double-blind, placebo-controlled trial of 247 patients who ... and liver enzymes; however, vitamin E was more successful for ... associated with fatty liver disease, insulin resistance, and obesity, and ... have NASH. The disease progresses to inflammation in the liver ...
... (Nasdaq: GPRO ) announced today that the Company will ... York on November 3, 2009 at approximately 2:10 p.m. Eastern ... Conference in New York on November 18, 2009 at approximately ... be webcast live and may be accessed through a link ...
Cached Medicine Technology:Vitamin E Improves NASH 2Gen-Probe to Webcast Two Upcoming Investor Presentations 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: