Navigation Links
NIH study finds HIV-positive young men at risk of low bone mass
Date:6/19/2012

Young men being treated for HIV are more likely to experience low bone mass than are other men their age, according to results from a research network supported by the National Institutes of Health. The findings indicate that physicians who care for these patients should monitor them regularly for signs of bone thinning, which could foretell a risk for fractures. The young men in the study did not have HIV at birth and had been diagnosed with HIV an average of two years earlier.

Earlier studies have shown that adults with HIV also have bone loss and increased risk for bone fractures, associated in part with the use of certain anti-HIV medications.

"The young men in the study had been taking anti-HIV medications for a comparatively short time, yet they still had lower bone mineral density than other men their age," said co-author Bill G. Kapogiannis, M.D., of the Pediatric, Adolescent, and Maternal AIDS Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). "These findings suggest a short-term impact of HIV therapy on bone at ages when people are still growing and building bone mass. This raises concern about the risk of fracture as they age."

For the HIV-infected young men, on average, bone density in the hip was 5-8 percent lower, and in the spine 2-4 percent lower, than for study participants without HIV.

The study was not designed to determine the cause of the bone loss and cannot rule out the possibility that low bone mass preceded the young men's HIV infection. The researchers noted that all the young men had several risk factors for bone loss, such as tobacco and alcohol use, and low intake of calcium and vitamin D (needed to absorb calcium.)

The study was conducted by lead authors Kathleen Mulligan, Ph.D., of the University of California, San Francisco; Grace Aldrovandi, M.D., of Children's Hospital Los Angeles and the University of Southern California; Dr. Kapogiannis, and seven other researchers affiliated with the NICHD-supported Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN).

Their findings appear in Clinical Infectious Diseases.

Additional funding was provided by the NIH's National Institute on Drug Abuse, the National Center for Research Resources and the National Center for Advancing Translational Sciences.

Some 250 teens and young men (14 to 25 years old) participated in the study. About 88 percent of the study participants identified themselves as African-American or Hispanic and all lived in urban areas. The participants underwent whole body scans to measure their bone density as well as the distribution of fat and lean muscle mass in certain regions of their bodies. Participants also answered questions about their medical history, and diet, exercise and other lifestyle habits.

The researchers calculated the density of bones in the body as a whole, as well as the spine and hipbones. These bones are more susceptible than other bones to bone loss, Dr. Mulligan explained. The researchers also assessed total body fat and amounts of fat in the arms, legs and trunk.

The researchers found that the HIV-positive participants who had not yet begun treatment tended to have less body fat than either their counterparts on medication or the study's HIV-negative participants.

Both bone density and the calcium and other mineral content of bones tended to be lowest in participants taking medication for HIV. Youth with HIV who had not begun treatment had higher bone mass levels than HIV positive youth who were on anti-HIV regimens, but lower bone mass levels than youth who did not have HIV. Participants' responses to questions about diet indicated that at least half of them did not consume sufficient calcium or vitamin D. The researchers also found that more than 30 percent of all the participants smoked. Half said they did not get regular exercise. Smoking and lack of exercise can contribute to weaker bones. The study authors noted that additional studies are needed to follow HIV-positive young men long term to determine whether bone loss during adolescence increases the risk of fractures later in life.

"None of the young men we saw is in immediate risk of fracture," said Dr. Mulligan. "However, our results indicated that it would be a good idea for young men newly diagnosed with HIV to make sure they exercise, get enough calcium and vitamin D, quit smoking and limit alcohol consumption."

Researchers in the ATN Network previously found that vitamin D supplements might help protect the bones of people taking the anti-HIV drug tenofovir.


'/>"/>

Contact: Robert Bock or Marianne Glass Miller
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
Source:Eurekalert

Related medicine news :

1. More Than Half of Resident Docs Have Worked While Sick: Study
2. Teen Drinkers May Feel Like Social Outcasts: Study
3. Giving makes young children happy, UBC study suggests
4. Study finds that single mothers can reduce stress by playing, engaging with children
5. Study: Willingness to be screened for dementia varies by age but not by sex, race or income
6. Dramatic Rise in Kids Hospitalized With High Blood Pressure: Study
7. Kidney Disease May Be as Harmful to Heart as Heart Attack: Study
8. Arthritis Treatment Linked to Liver Problems in Study
9. Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers
10. Some May Drink More After Weight-Loss Surgery: Study
11. American Kids Getting Fewer Prescription Drugs: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... awareness about the dangers associated with chronic pain and the benefits of holistic treatments, ... for individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
Breaking Medicine Technology: