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NIH study confirms location of stem cells near cartilage-rich regions in bones
Date:4/26/2010

ination of the tumor cells and of cells from the same locations in mice that did not have tumors confirmed that the cells were bone stem (stromal) cells. Specifically, proteins on the surface of the cells were identical to proteins found on other types of stem cells. Moreover, the tumors formed only at locations where bone is actively growing, even in the adult mouse skeleton.

"We didn't notice abnormal growth in the skull, for example," said Dr. Stratakis.

The findings open up two avenues for additional research. Studies to identify the chemical signals that initiate the formation of new bone tissue could lead to new techniques for regenerating damaged or injured bone. Similarly, studies of the chemical events that trigger the initial stages of tumor formation may lead to ways to prevent or treat bone tumors.


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Contact: Robert Bock
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
Source:Eurekalert

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