Navigation Links
NIH scientists identify protective role for antibodies in Ebola vaccine study
Date:1/14/2013

WHAT:
Researchers at the National Institutes of Health (NIH) and Oregon Health & Science University (OHSU) have found that an experimental vaccine elicits antibodies that can protect nonhuman primates from Ebola virus infection. Ebola virus causes severe hemorrhagic fever in humans and nonhuman primates, meaning that infection may lead to shock, bleeding and multi-organ failure. According to the World Health Organization, Ebola hemorrhagic fever has a fatality rate of up to 90 percent. There is no licensed treatment or vaccine for Ebola virus infection.

Several research groups have developed experimental vaccine approaches that protect nonhuman primates from Ebola virus and the closely related Marburg virus. These approaches include vaccines based on DNA, recombinant adenovirus, virus-like particles, and human parainfluenza virus 3. But how these vaccine candidates confer protection is an area that is still being explored: Do they activate immune cells to kill the invading virus? Or do they elicit antibodies that block infection?

In this study, scientists at NIH's National Institute of Allergy and Infectious Diseases and OHSU's Vaccine & Gene Therapy Institute built on earlier work with an experimental vaccine composed of an attenuated vesicular stomatitis virus carrying a gene that codes for an Ebola virus protein. They observed how cynomolgus macaques responded to a challenge of Ebola virus before and during treatment with the vaccine and in conjunction with depleted levels of immune cells. Their results showed that important immune cellsCD4+ T cells and CD8+ T cellshad a minimal role in providing protection, while antibodies induced by the vaccine appeared to be critical to protecting the animals.

The scientists say this finding will help improve future Ebola virus vaccine development. They plan to focus their studies on what level of antibody production is needed to establish protection from Ebola virus infection in huma
'/>"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... The human brain can preserve oxygen to protect itself ... Although dehydration significantly reduces blood flow to ... brain compensates by increasing the amount of oxygen it ... us understand a lot more about how the human ... first author Steven Trangmar, a researcher at Brunel University, ...
(Date:7/25/2014)... July 25, 2014 A new study conducted ... revealed that 39 percent of all children in the survey under ... The survey looked at 2,505 children during the years of 2011 ... years of age. The final result was that about two ... Many of these children were from lower-income families and were of ...
(Date:7/25/2014)... July 25, 2014 On July ... Nuanced Media client and the nation’s number one ... employee handbooks, announced their partnership with TransAct Merchant ... a registered ISO/MSP of Chase Paymentech Solutions, LLC, ... processing industry. Companies that are members of TransAct’s ...
(Date:7/25/2014)... Philadelphia, PA (PRWEB) July 25, 2014 ... that Valerie D. Weber, MD, MS, FACP, has been appointed ... , Weber will join Drexel from The Commonwealth Medical College, ... Sciences, associate dean for clinical affairs, and professor of medicine. ... of The Commonwealth Medical College, Weber had a major role ...
(Date:7/25/2014)... 25, 2014 (HealthDay --, Treatment for lymphoma may lower ... and non-Hodgkin lymphoma, which are cancers of the body,s ... still in their reproductive years. For men, treatment for ... most men regain their fertility within two years of ... about the possibility of this significant side effect before ...
Breaking Medicine News(10 mins):Health News:Human Brain Has Coping Mechanism for Dehydration 2Health News:North York Dental Provides Services to Toronto Children in Light of Growing Demand 2Health News:North York Dental Provides Services to Toronto Children in Light of Growing Demand 3Health News:Nuanced Media Client, CEDR HR Solutions, Partners with TransAct to Serve Medical, Dental, and Eye Care Professionals 2Health News:Valerie D. Weber, MD, Appointed Vice Dean for Education at Drexel University College of Medicine 2Health News:Valerie D. Weber, MD, Appointed Vice Dean for Education at Drexel University College of Medicine 3Health News:Lymphoma Treatment May Harm, Halt Men's Sperm Production 2
... by blocking immune signaling by a protein receptor, a ... to protect against North American strains of the virus, ... the receptor’s key role in controlling West Nile infection ... Virology that compares the genetics of an illness-causing Texas ...
... been a sharp rise in the number of HIV cases in Victoria ... since the early 1990s//. ,In Victoria, nearly 200 new HIV ... an increase of 38% than at the same time last year. 129 ... ,The numbers have been on the rise since 1999, however, it rose ...
... the gray matter has offered an insight into a trait ... – SELFISHNESS//. Bewildering all the same, why are some people ... believe in being the epitome of selflessness! ,Scientists ... the front of the brain, termed as the dorsolateral prefrontal ...
... recent research, drinking cola can lead to brittle bones in ... carbonated drink women consumed, the weaker// were their bones. ... not to drink too much of cola. The phosphoric acid, ... is assumed to be responsible for the problem. ...
... Organization (WHO) for the first time issued Global Air Quality ... pollution that kills 2 million// people each year with most ... WHO appealed to governments to enhance air quality in the ... Manila revealed that almost 3,00,000 lives could be saved every ...
... reasons known to cause deaths in women in developing ... the number of deaths caused// because of uncontrolled bleeding ... extensive research and studies conducted by researchers from the ... the National Institutes of Health . The studies have ...
Cached Medicine News:Health News:Study Unveils West Nile Virus Immune Evasion, Points to Vaccine Development 2Health News:Study Unveils West Nile Virus Immune Evasion, Points to Vaccine Development 3Health News:Cola increases risk of Osteoporosis!! 2Health News:A Safe Drug For Safe Delivery 2
(Date:7/24/2014)... CITY, Calif., July 24, 2014  Abaxis, Inc. (NasdaqGS: ... point-of-care blood analysis systems, today reported financial results for ... First quarter overview: , Revenues of $47.5 ... , Diluted EPS of $0.21, up 50% over last ... Medical market revenues of $7.2 million, up 20% over ...
(Date:7/24/2014)... , July 24, 2014  IRIDEX Corporation (NASDAQ: ... release its second quarter 2014 financial results after the ... In conjunction with the release, the Company will host ... 5:00 p.m. Eastern Time on Thursday, July ... quarter and other business developments. Interested parties ...
(Date:7/24/2014)... , July 24, 2014 Omnicell, Inc. ... of medication and supply management solutions and analytics ... Thursday, July 31, to discuss the Company,s Second ... Second Quarter 2014 earnings conference call and webcastWhen: ... , Randall Lipps, chairman, president and chief executive ...
Breaking Medicine Technology:Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 2Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 3Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 4Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 6Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 7Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 8Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 9Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 10Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 11Omnicell to Release Second Quarter 2014 Earnings Results on July 31 2
... June 13, 2011 AmbiCom Holdings, Inc. (OTCQB: ABHI), ... medical equipment suppliers, today announced that it has signed ... AmbiCom Technology, Inc. ("ATI") subsidiary and E-Care Technology Corporation, ... and runs for a period of three years. ...
... 13, 2011 Uroplasty, Inc. (NASDAQ: UPI ), ... proprietary products to treat voiding dysfunctions, today announced it has ... Russell 3000® Index and the Russell Global® Index posted by ... These changes are expected to go into effect after the ...
Cached Medicine Technology:AmbiCom Forms Joint Alliance With E-Care Technology Corporation 2AmbiCom Forms Joint Alliance With E-Care Technology Corporation 3Uroplasty on Preliminary List of Additions to Russell 3000® and Russell Global® Indexes 2
... System supports approaches to Admitting/Discharge/Transfer ... record keeping functions using a ... facilities and cut across institutional ... community clinics, physician, agency, nursing ...
... Dairylands Clinical Information Management ... suite of integrated applications ... departments and automate administrative ... The applications allow organizations ...
... include a Patient Face Sheet, ... many as six custom tabs, ... information is important for you ... Import Manager utility lets you ...
... WEBeDoctor® Physician-office® is an ... physicians, (Solo practice, group ... to complete their normal ... It is a front ...
Medicine Products: