Navigation Links
NIH scientists identify most proteins made by parasitic worm

A team led by Thomas B. Nutman, M.D., of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has completed a large-scale analysis of most of the proteins produced by Brugia malayi, one kind of parasitic worm that causes lymphatic filariasis, or elephantiasis. The greatly swollen lower limbs that can result from chronic infection with this mosquito-borne parasite can be severely disabling.

The investigators characterized 7,103 proteins produced in various stages of the worm's lifecycle, including male and female adult forms that live in the body's lymphatic system; asexual stages that circulate in human blood; and the larval stage that first infects humans.

The nature and relative amounts of proteins produced during successive stages of the worm's lifecycle provide clues to their likely importance in creating and maintaining infection. For example, proteins made in abundance by larval worms might serve as targets for developing vaccines to prevent infections. Proteins made in large amounts by adult worms might serve as targets for developing drugs to treat infections and potentially halt transmission of the parasite from an infected person to a potential mosquito carrier.

In addition to identifying the worm-made proteins, the team also characterized most of the proteins made by Wolbachia, bacteria that live inside B. malayi. Human inflammatory immune responses to the combined presence of Wolbachia and B. malayi are thought to be responsible for many symptoms of lymphatic filariasis.

Sequencing of the B. malayi genome, which enabled this research on the worm's proteins to be carried out, was completed by National Institutes of Health-funded researchers in 2007.


Contact: Anne A. Oplinger
NIH/National Institute of Allergy and Infectious Diseases

Page: 1

Related medicine news :

1. Heart scientists discover protein that may be 1 cause of heart failure
2. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
3. Scientists discover new drug target for squamous cell carcinoma
4. Queens scientists teaming up to cure premature baby blindness
5. Scientists design new anti-flu virus proteins using computational methods
6. Scientists use genetically altered virus to get tumors to tattle on themselves
7. Scientists Find MRSA Germ in Supermarket Meats
8. Weizmann Institute scientists show: How adversity dulls our perceptions
9. McMaster scientists find protein’s bad guy role in prostate cancer
10. UCLA scientists discover way to amp up power of killer T cells
11. Yale and Rush University scientists receive Sanberg Awards from ASNTR
Post Your Comments:
(Date:11/27/2015)... ... 2015 , ... The print component of “Supporting Our Caregivers” ... New York, Minneapolis, South Florida, with a circulation of approximately 250,000 copies and ... vast social media strategy and across a network of top news sites and ...
(Date:11/27/2015)... ... 2015 , ... A simply groundbreaking television series, "Voices in America", which is ... an array of issues that are presently affecting Americans. Dedicated to providing the world ... is changing the subjects consumers focus on, one episode at a time. , ...
(Date:11/27/2015)... Rosa, CA (PRWEB) , ... November 27, 2015 , ... ... Northern California Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at ... meeting. They observed that both STEMI and Sepsis conditions present in similar ways and ...
(Date:11/26/2015)... ON (PRWEB) , ... November 26, 2015 , ... ... of a real-time eReferral system for diagnostic imaging in the Waterloo region. Using ... BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) without ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... process, participated in the 61st annual Employee Benefits Conference. The Employee Benefits Conference ... Sunday, November 8th through Wednesday, November 11th, 2015. The conference was held at ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy ... new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for ... new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for ... has found that immunotherapy can be efficiently ...
(Date:11/26/2015)... Research and Markets ( ) ... Future Horizons and Growth Strategies in the Japanese ... Segment Forecasts, Competitive Intelligence, Emerging Opportunities" report ... --> This new 247-page report ... drug monitoring market, including emerging tests, technologies, instrumentation, ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and Markets ... "Advanced Wound Care Market by Type (Dressings, Therapy ... User (In-Patient Facility, Out-Patient Facility), and Geography - Global ... --> --> The ... definition and forecast of the global advanced wound care ...
Breaking Medicine Technology: