Navigation Links
NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
Date:2/3/2014

WHAT:

NIH scientists have discovered a mechanism involved in stabilizing key HIV proteins and thereby concealing sites where some of the most powerful HIV neutralizing antibodies bind, findings with potential implications for HIV vaccine research. Numerous spikes jut out of the surface of HIV, each containing a set of three identical, bulb-shaped proteins called gp120 that can be closed together or spread apart like the petals of a flower. Some of the most important sites targeted by HIV neutralizing antibodies are hidden when the three gp120s, or the trimer, are closed, and the gp120 trimer remains closed until the virus binds to a cell.

The researchers discovered that certain amino acids located on the gp120 protein undergo a process that stabilizes the trimer in its closed position. In this process, called sulfation, the amino acids acquire a sulfur atom surrounded by four oxygen atoms. By either blocking or increasing sulfation of these amino acids, the researchers changed the sensitivity of the virus to different neutralizing antibodies, indicating that the trimer was being either opened or closed.

The scientists suggest that if the synthesized gp120 widely used in HIV research were fully sulfated during manufacture, the resulting product would adopt a more true-to-life structure and more closely mirror the way the immune system sees unbound HIV. This might help generate a more effective HIV vaccine. The researchers add that full sulfation of gp120 may enable scientists to crystallize the molecule more readily, which also could advance HIV vaccine design.

ARTICLE:

R Cimbro et al. Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity. Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1314718111 (2014).

WHO:

Paolo Lusso, M.D., Ph.D., chief of the Viral Pathogenesis Section in the L
'/>"/>

Contact: Laura S. Leifman
laura.sivitz@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists develop powerful new animal model for metastatic prostate cancer
2. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
3. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
4. NCCS scientists discover gene regulation is dependent on protein ANP32E
5. Scientists make your stomach turn bright green if you have an ulcer
6. Scientists reduce protein crystal damage, improve pharmaceutical development
7. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
8. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
9. Scientists discover that short-term energy deficits increase factors related to muscle degradation
10. CNIO scientists create the first large catalog of interactions between drugs and proteins
11. Over 70 new centers to train tomorrows engineers and scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 2015 Bon Secours New York Health ... Schervier Nursing Care Center family last week. The Sisters ... in Yonkers which is scheduled to close later this ... of the Sisters of Charity of New York, the ... to place their Sisters at Schervier Nursing Care Center ...
(Date:3/31/2015)... (PRWEB) March 31, 2015 Cosmetic Town, ... the Internet, is proudly enduring adding news to its ... and the consumers of plastic surgery and cosmetic medicine ... user-friendly pages and interconnected sections, the Cosmetic Town community ... addition to the Cosmetic Town site navigation, News and ...
(Date:3/31/2015)... 31, 2015 Karen A. Daley, Ph.D. ... Rivier University’s Commencement ceremony on May 9, ... letters in recognition of her eminent career as a ... a front-line caregiver and senior staff nurse at Brigham ... advancing to leadership roles, including President of the American ...
(Date:3/31/2015)... Indosoft, developer of the Q-Suite call center software suite, announces ... 5.x line. The industry leading contact center ACD ... for more than a decade. By announcing an end of ... fully embrace newer Asterisk features and improve performance. , Q-Suite ... more than a decade. The use of Asterisk, a free, ...
(Date:3/31/2015)... Clinovo, a leading provider of cloud-based ... the premiere voice of Northern California’s Life Science ... , BayBio brings together the collective strength ... productive life science cluster, helping companies grow, connect ... pressing challenges. , “We are thrilled to ...
Breaking Medicine News(10 mins):Health News:Bon Secours New York Health System Welcomes Retired Sisters of Charity to the Family 2Health News:Cosmetic Town is Now Transforming so Consumer can Better Navigate 2Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 2Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 3Health News:Indosoft Announces End of Life for Asterisk 1.4 Support in Q-Suite 5 Call Center Software 2Health News:Clinovo Joins BayBio Membership Program, The Leading Life Science Association in Northern California 2
... CryoCor, Inc. (Nasdaq:,CRYO), a medical device company focused on ... Brennan, President and Chief,Executive Officer, and Gregory J. Tibbitts, ... Group First Annual Growth Conference in,New York, NY on ... The Grand,Hyatt Hotel. A live Web cast and ...
... Sept. 17 John Brooke, General Manager of,Billian,s ... speaking at Dreamforce ,07 Global Gathering, Salesforce.com,s 5th,Annual ... week. Dreamforce is the ultimate gathering of ... base of Salesforce and AppExchance,users spanning industries, roles ...
... screening may only be modestly accurate, according to researchers from ... North Carolina. In a study that appears in the October ... the usefulness of a scale that asks patients in primary ... to 10 (worst pain). , Universal pain screening ...
... September ... 18th, NEW YORK, Sept. ... meet their millennium,commitment to halve hunger by 2015, the international development agency,ActionAid,s HungerFREE ... table" of the 62nd United Nations General Assembly,Meetings. "The UN is failing ...
... Contrary to concerns that restricting work hours for ... or the residents education, a study in the September ... Surgeons found that limiting work hours does not compromise ... study found that the new model improved overall teaching ...
... ROSEVILLE, Calif., Sept. 17 S.M.A.R.T. Association,Inc. ("SMART"), ... Council,Member" of the Smart Card Alliance, a not-for-profit, ... and,widespread application of Smart Card technology. The ... for smart card,technology, leading industry discussions on the ...
Cached Medicine News:Health News:CryoCor to Present at Maxim Group First Annual Growth Conference in New York 2Health News:Billian's HealthDATA GM Speaking on Dreamforce 07 Panel 2Health News:Rating your pain from 0 to 10 might not help your doctor 2Health News:HungerFREE Campaign Tells UN: 'Put food on the table' 2Health News:Study finds limiting work hours for surgical residents enhances training 2Health News:SMART Association Becomes 'Healthcare Council Member' of Smart Card Alliance 2
(Date:3/31/2015)... ROCHELLE, N.Y. , March 31, 2015 /PRNewswire-USNewswire/ ... it will be featured in the American Medical ... by ITN Productions. AMGA,s "High Performing ... on the challenges facing the nation,s healthcare system ... Medical Letter is profiled along with other leading ...
(Date:3/31/2015)... -- Accelerated orthodontic treatment will be a featured ... Annual Session, May 15-19, as seven of the ... ® . Manufactured by OrthoAccel ® Technologies, ... a FDA-cleared, Class II medical device that speeds ... percent with just 20 minutes of daily use. ...
(Date:3/31/2015)... DALLAS , March 31, 2015 ... H1 2015" therapeutic market research report of 68 ... its online business intelligence library. The ... information on the therapeutic development for Pemphigus ... therapeutics assessment by drug target, mechanism of action ...
Breaking Medicine Technology:AMGA's High Performing Health News Program Features The Medical Letter 2Leading Orthodontists to Advance Accelerated Treatment at AAO 2015 2Leading Orthodontists to Advance Accelerated Treatment at AAO 2015 3Pemphigus Therapeutic Development and Pipeline Review H1 2015 2Pemphigus Therapeutic Development and Pipeline Review H1 2015 3Pemphigus Therapeutic Development and Pipeline Review H1 2015 4
... GSK ) announced today that the U.S. Centers ... Immunization Practices (ACIP) recommended that CERVARIX® [Human papillomavirus bivalent ... girls and young women to protect against cervical pre-cancers ... 18. The ACIP specifically recommended CERVARIX for routine ...
... Accuray Incorporated (Nasdaq: ARAY ), a global ... to establish an America,s region thereby establishing regionalized management ... , The formation of this new Americas region, along ... Japan, gives each region control of revenue and profitability ...
Cached Medicine Technology:CDC Advisory Committee Recommends Cervarix To Prevent Cervical Cancer in Girls and Young Women 2CDC Advisory Committee Recommends Cervarix To Prevent Cervical Cancer in Girls and Young Women 3CDC Advisory Committee Recommends Cervarix To Prevent Cervical Cancer in Girls and Young Women 4Accuray Announces Regionalized Management Strategy for Americas 2Accuray Announces Regionalized Management Strategy for Americas 3
For primary and revision cases...
The MPF cup is specifically designed to achieve high primary stability, a critical factor for long term success....
The Protract stem offers a press-fit option which will allow choice of standard or lateralized neck offsets while keeping a consistent leg length....
Implex cemented hip stem....
Medicine Products: