Navigation Links
NIH scientists discover how HIV kills immune cells
Date:6/5/2013

WHAT:

Untreated HIV infection destroys a person's immune system by killing infection-fighting cells, but precisely when and how HIV wreaks this destruction has been a mystery until now. New research by scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, reveals how HIV triggers a signal telling an infected immune cell to die. This finding has implications for preserving the immune systems of HIV-infected individuals.

HIV replicates inside infection-fighting human immune cells called CD4+ T cells through complex processes that include inserting its genes into cellular DNA. The scientists discovered that during this integration step, a cellular enzyme called DNA-dependent protein kinase (DNA-PK) becomes activated. DNA-PK normally coordinates the repair of simultaneous breaks in both strands of molecules that comprise DNA. As HIV integrates its genes into cellular DNA, single-stranded breaks occur where viral and cellular DNA meet. Nevertheless, the scientists discovered, the DNA breaks during HIV integration surprisingly activate DNA-PK, which then performs an unusually destructive role: eliciting a signal that causes the CD4+ T cell to die. The cells that succumb to this death signal are the very ones mobilized to fight the infection.

According to the scientists, these new findings suggest that treating HIV-infected individuals with drugs that block early steps of viral replicationup to and including activation of DNA-PK and integrationnot only can prevent viral replication, but also may improve CD4+ T cell survival and immune function. The findings also may shed light on how reservoirs of resting HIV-infected cells develop and may aid efforts to eliminate these sites of persistent infection.


'/>"/>

Contact: Laura S. Leifman
laura.sivitz@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... As recently as 2015, rhinoplasty was ... American Society of Plastic Surgeons. Some patients want to make a change in the ... and improve their breathing ability. The team at usrhinoplasty.org is expanding its ...
(Date:2/21/2017)... ... February 21, 2017 , ... Ray Insurance Agencies, a Dallas area firm ... County, is embarking on a six month charity event aimed at raising local support ... Cancer is one of the deadliest diseases in America; more than 7.5 million people ...
(Date:2/21/2017)... (PRWEB) , ... February 21, 2017 , ... ... and conference coverage in veterinary medicine, will be launching its first bi-monthly issue ... health and medicine, business and practice management, and One Health. , In ...
(Date:2/21/2017)... ... February 21, 2017 , ... Each February ... History Month (officially African American History Month ). This month-long ... of a diverse race of people, but also the opportunity to examine the ...
(Date:2/21/2017)... California (PRWEB) , ... February 21, 2017 , ... ... world with over 50,000 participants. The connected care demonstration spanned multiple health ... the National Coordinator, roughly 30% of providers have no Health Information Exchange outside ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Feb. 21, 2017 Sangamo Therapeutics, Inc. (Nasdaq: ... that the company will release its fourth quarter and ... on Tuesday, February 28, 2017. The press release will ... ET, which will be open to the public via ... will review its financial results and provide a business ...
(Date:2/21/2017)... Feb. 21, 2017 ... a new imaging solution that connects Lexmark multifunction printers ... of the world,s leading scanning and indexing software solutions ... enables hospitals to use a Lexmark MFP at the ... Solarity workflow, helping facilities reach HIMSS Stage 7 ...
(Date:2/21/2017)... , Feb. 21, 2017 EMS ... mobile and web based platforms with focus on ... announce the signing of a worldwide, on-revocable and ... a full-service medical transportation company serving healthcare organizations ... . EpicMD,s platform eliminates ...
Breaking Medicine Technology: