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NIH scientists discover crucial control in long-lasting immunity
Date:10/10/2008

ells have antigenic arms similar to those of B cells. Dr. Cannons explains, "Some cell receptors act like Velcro, allowing two different cells to stick together. We think that different cells use different receptor signals to stick together. A signal that does not affect the sticking between two cell types may well prevent another two cell types from interacting."

These findings not only help explain the basis for the immunodeficiency disease known as XLP, but also provide important new insights into the exquisitely specific communications between different types of immune cells.

According to Dr. Schwartzberg, "This work provides a great example of the power of combining mouse models of human diseases with live imaging microscopy to uncover secrets of the immune system and help discover new ways to combat disease."

"This work nicely demonstrates both the value of interdisciplinary collaboration and that exploring relatively rare genetic diseases can offer important insights into biological processes that are important to the health of all of us," says Alan E. Guttmacher, M.D., acting director, NHGRI.


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Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

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