Navigation Links
NIH scientists discover crucial control in long-lasting immunity
Date:10/10/2008

National Institutes of Health (NIH) scientists have identified a protein that plays matchmaker between two key types of white blood cells, T and B cells, enabling them to interact in a way that is crucial to establishing long-lasting immunity after an infection. Their finding may also explain why some individuals who have a genetic defect that prevents them from making this proteincalled SAPsuffer from lethal infections with a common virus that otherwise is rarely fatal (Epstein-Barr virus), while others with this genetic defect have problems with B-cell lymphomas.

The new study was a collaboration between the laboratories of NIH scientists Ronald Germain, M.D., Ph.D., at the National Institute of Allergy and Infectious Diseases (NIAID), and Pamela Schwartzberg, M.D., Ph.D., at the National Human Genome Research Institute (NHGRI). Their findings appear in the Oct. 9 issue of Nature.

When a B cell encounters a virus or other foreign agent, the B cell engulfs the virus and parts of it, called antigens, become displayed on the surface of the B cell. These antigens signal to T cells, which have specialized receptors that can bind to antigens on the B cells. Thus coupled, the T cells deliver signals that help B cells multiply and produce antibodies that will eventually destroy the offending virus. A critical tissue structure that facilitates these events is the germinal center, which normally forms after an infection within the lymph nodes, organs in which immune cells gather to carry out their functions.

"Understanding how B and T cells interact in the lymph nodes is crucial, because the germinal centers are the sites where long-lasting immunity begins," says NIAID Director Anthony S. Fauci, M.D. "If we can unravel how the body naturally builds defenses against repeat infections, it will aid us in developing more effective vaccines."

In some individuals, B cells do not make antibodies in response to infections and immu
'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... The Coalition for,Pulmonary Fibrosis today announced 2007 National ... weekend in Washington, D.C., a,congressional reception that includes a ... with the National Institutes of Health. More,than 40 Idiopathic ... the Hill next week to meet with Members of ...
... As we age, our brains slowly shrink in volume ... lobes, the seat of executive functioning. Executive functions include ... aging population, an inability to inhibit unwanted thoughts and ... awry. , In a study appearing in the ...
... rather than womens newfound economic independence can explain why ... and why the trend may only be temporary, says ... women acquired significant control over their own fertility, and ... burden of raising children, says Lonnie Aarssen, a Biology ...
... 21 September 2007: New guidelines on the diagnosis and ... the Archives of Disease in Childhood, are set to ... the most common food allergy in children.1 The Guidelines ... Allergy recommend only extensively hydrolysed (eHF) and amino acid-based ...
... may take decades to reverse the health threats, experts say ... and ,90s, Americans tried to control their weight by watching ... paid little mind to total calories and physical activity. And ... , "It was just an end run around the issue ...
... RESTON, Va. -- Attention scientific researchers: SNM invites ... especially those involving non-radioactive molecular imaging techniques and ... June 1418, 2008, in New Orleans, La. SNM, ... nuclear medicine professionals, will showcase these studies in ...
Cached Medicine News:Health News:CPF Announces National IPF Awareness Week Activities 2Health News:CPF Announces National IPF Awareness Week Activities 3Health News:Brain atrophy in elderly leads to unintended racism, depression and problem gambling 2Health News:Is there really a 'mommy' gene in women? 2Health News:New guidelines set to improve standard of cows' milk allergy care 2Health News:New guidelines set to improve standard of cows' milk allergy care 3Health News:Childhood Obesity Epidemic a Long-Term Challenge 2Health News:Childhood Obesity Epidemic a Long-Term Challenge 3Health News:SNM seeks novel approaches to molecular imaging to showcase at annual meeting 2
(Date:1/14/2014)... 14, 2014  Luminex Corporation (Nasdaq: LMNX ... for the fourth quarter of 2013 on Monday, February ... scheduled for release after the close of trading. ... will hold a conference call to discuss the operating ... twelve months ended December 31, 2013 on February 3, ...
(Date:1/14/2014)... Ore. , Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s ... a targeting guide with accompanying instrumentation to place and ... adjunct to the soft tissue (e.g. ligament) repair or ... tissue repair heals. (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ... maintain the anatomical reduction (spacing) of the scaphoid and ...
(Date:1/14/2014)... N.Y. , Jan. 14, 2014   Oligomerix, ... development of disease modifying therapeutics for Alzheimer,s disease ... relocation of its corporate headquarters to ... 2014 and expanded lease agreement for additional laboratory ... Oligomerix, which is focused on the development of ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... HealthCare Pharmaceuticals is pleased to announce it will support the New Jersey ... is the second year in a row that Bayer HealthCare Pharmaceuticals has sponsored the ... , , ... , , ...
... Calif. , July 22 SRI International and the ... Collaborative (the Multidisciplinary Initiative for Surgical Technology Research Advanced Laboratory), in ... $1M grant by the Food and Drug Administration (FDA) ... care. , , ...
Cached Medicine Technology:Bayer HealthCare Pharmaceuticals Supports New Jersey Governor's School in the Sciences at Drew University 2Bayer HealthCare Pharmaceuticals Supports New Jersey Governor's School in the Sciences at Drew University 3SRI International and Stanford University School of Medicine's MISTRAL Collaborative and the Institute for Pediatric Innovation Awarded FDA Grant to Accelerate Commercialization of Pediatric Medical Devices 2SRI International and Stanford University School of Medicine's MISTRAL Collaborative and the Institute for Pediatric Innovation Awarded FDA Grant to Accelerate Commercialization of Pediatric Medical Devices 3SRI International and Stanford University School of Medicine's MISTRAL Collaborative and the Institute for Pediatric Innovation Awarded FDA Grant to Accelerate Commercialization of Pediatric Medical Devices 4SRI International and Stanford University School of Medicine's MISTRAL Collaborative and the Institute for Pediatric Innovation Awarded FDA Grant to Accelerate Commercialization of Pediatric Medical Devices 5SRI International and Stanford University School of Medicine's MISTRAL Collaborative and the Institute for Pediatric Innovation Awarded FDA Grant to Accelerate Commercialization of Pediatric Medical Devices 6SRI International and Stanford University School of Medicine's MISTRAL Collaborative and the Institute for Pediatric Innovation Awarded FDA Grant to Accelerate Commercialization of Pediatric Medical Devices 7
Latex agglutination slide test for the qualitative and semi-quantitative in vitro determination of Rheumatoid Factor in serum....
For the quantitative in vitro determination of IgE in Human Serum or Plasma....
For the quantitative in vitro determination of IgG in serum and plasma. This product is suitable for use on the Aeroset...
Latex-enhanced immunoturbidimetric assay for the quantitative in vitro determination of C-reactive protein in serum and plasma...
Medicine Products: