Navigation Links
NIH scientists discover crucial control in long-lasting immunity
Date:10/10/2008

National Institutes of Health (NIH) scientists have identified a protein that plays matchmaker between two key types of white blood cells, T and B cells, enabling them to interact in a way that is crucial to establishing long-lasting immunity after an infection. Their finding may also explain why some individuals who have a genetic defect that prevents them from making this proteincalled SAPsuffer from lethal infections with a common virus that otherwise is rarely fatal (Epstein-Barr virus), while others with this genetic defect have problems with B-cell lymphomas.

The new study was a collaboration between the laboratories of NIH scientists Ronald Germain, M.D., Ph.D., at the National Institute of Allergy and Infectious Diseases (NIAID), and Pamela Schwartzberg, M.D., Ph.D., at the National Human Genome Research Institute (NHGRI). Their findings appear in the Oct. 9 issue of Nature.

When a B cell encounters a virus or other foreign agent, the B cell engulfs the virus and parts of it, called antigens, become displayed on the surface of the B cell. These antigens signal to T cells, which have specialized receptors that can bind to antigens on the B cells. Thus coupled, the T cells deliver signals that help B cells multiply and produce antibodies that will eventually destroy the offending virus. A critical tissue structure that facilitates these events is the germinal center, which normally forms after an infection within the lymph nodes, organs in which immune cells gather to carry out their functions.

"Understanding how B and T cells interact in the lymph nodes is crucial, because the germinal centers are the sites where long-lasting immunity begins," says NIAID Director Anthony S. Fauci, M.D. "If we can unravel how the body naturally builds defenses against repeat infections, it will aid us in developing more effective vaccines."

In some individuals, B cells do not make antibodies in response to infections and immu
'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 28, 2014 The National League for ... DrPH, MN, RN, FAAN, became the inaugural director of ... Advancement of the Science of Nursing Education , effective ... comprise the NLN Home for Transformative Excellence, established with ... year ago. , Under Dr. Dennis’s leadership, the ...
(Date:8/27/2014)... August 28, 2014 Recently, Skmen.com, a ... designs of celebrity bodycon dresses . The company ... has thousands of trendy items in stock and ready ... casual outfits, long sleeve sweater dresses and so forth. ... stunning colours. , “We are proud to announce ...
(Date:8/27/2014)... 2014 Philadelphia, PA. Inc. magazine ... Inc. 500 list, an exclusive ranking of the nation’s ... comprehensive look at the most important segment of the ... gained early exposure as members of the Inc. 500 ... , “Some of world’s greatest companies have had ...
(Date:8/27/2014)... All Canada Goose Parkas from ... from classic to modern. With unique detailing such as buttons, ... is a step up in opulence. Recently, the company has ... for 2014. , True enough, the new assortment ... discounts (up to 28% off) on all these brand new ...
(Date:8/27/2014)... Locating an approximate price for an insurance ... information before rates would be viewable. The Quotes Pros ... are distributed online using its policy locator at ... adult has access to review using the national finder ... for quotation distribution built in 2013 is now programmed ...
Breaking Medicine News(10 mins):Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 2Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 3Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 4Health News:Skmen.com Unveils Its New Celebrity Bodycon Dresses for Its Loyal Customers 2Health News:Inc Magazine Unveils 33rd Annual List of America's Fastest-Growing Private Companies - the Inc. 500 2Health News:CanadaGooseJackor.nu: 2014 Canada Goose Banff Parkas At Discounted Prices 2Health News:Life Insurance Quotes for Term Policies Now Found at Insurer Website Online 2
... more likely than others to introduce their infants to cow,s ... children at risk of health complications, according to a study ... and Poverty, New York. The study showed that women ... during their first or second trimester of pregnancy -- from ...
... Steven Reinberg HealthDay Reporter , MONDAY, June 28 ... cholesterol levels, statins don,t appear to reduce the chances of ... scientists have found. Statins are used widely to treat ... with heart disease and -- in more recent years -- ...
... ... California based laboratory equipment repair and instrument calibration services company, has been formally ... calibration lab., , ... (PRWEB) June 29, 2010 -- Beginning in 2009, the AL-TAR Quality ...
... Advanced ... percutaneous—or through the skin—techniques, according to a new study appearing online and in the ... ... 2010 -- Advanced imaging technologies have helped shift biopsy techniques away from more invasive ...
... Advanced imaging technologies have helped shift biopsy techniques away ... skintechniques, according to a new study appearing online and ... Radiology . Biopsythe removal of cells or ... The first percutaneous needle biopsy of the liver was ...
... A literature review, led by Dr. Joseph Lee, published in the ... Academy of Orthopaedic Surgeons ( JAAOS ) suggests that a ... back and leg pain in adults, but surgery is not for ... low back pain at some point in their lives Disks, ...
Cached Medicine News:Health News:WIC might prevent mothers from feeding cow's milk too early 2Health News:Statins May Not Be as Helpful for Those Without Heart Disease 2Health News:Statins May Not Be as Helpful for Those Without Heart Disease 3Health News:AL-TAR Services, Inc. Laboratory Is Now Accredited For ACLASS Standards 2Health News:Use of Less Invasive, Imaging-Guided Biopsies on the Rise 2Health News:Use of Less Invasive, Imaging-Guided Biopsies on the Rise 3Health News:Use of less invasive, imaging-guided biopsies on the rise 2Health News:Lower back pain and surgery 2
(Date:8/27/2014)... Aug. 27, 2014  Decision Resources Group finds ... oncology, hematology-oncology, rheumatology, gastroenterology, endocrinology and nephrology) expect ... a biosimilar has been assessed in to be ... choose to prescribe. Other key ... Acceptance of Biosimilars Across Physician Specialties ...
(Date:8/27/2014)... Fla. , Aug. 27, 2014 ... today that it has released a preview of its ... the pharmaceutical industry avoid drug shortages and maintain a ... The Plan, a first for the ... and biopharmaceutical industry members and describes how industry can ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 Reportlinker.com ... in its catalogue: Baby Food Eastern Europe ... Summary "Baby Food Eastern Europe 2014" is a new ... demand prospects in Eastern Europe , ... various trends. This report also examines trends which are ...
Breaking Medicine Technology:Surveyed Physicians Expect to Choose Between Future Biosimilars Based on Robustness and Number of Clinical Trials 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 3ISPE Releases First Look at its Plan to Prevent Drug Shortages 4Baby Food Eastern Europe 2014 2Baby Food Eastern Europe 2014 3Baby Food Eastern Europe 2014 4Baby Food Eastern Europe 2014 5Baby Food Eastern Europe 2014 6Baby Food Eastern Europe 2014 7Baby Food Eastern Europe 2014 8
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With polished ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... • BTN/1Q-CAB chairs are recommended for ... clean room, static control, health care ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... • BTN/1Q-CAB chairs are recommended for ... clean room, static control, health care ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
Medicine Products: