Navigation Links
NIH researchers identify key factor that stimulates brain cancer cells to spread
Date:8/18/2009

Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM). In a move toward therapy, the researchers showed that a small designer protein can block this activity and reduce the spreading of GBM cells grown in the laboratory.

GBM is the most lethal form of brain cancer, with about half of patients expected to die within a year of diagnosis. GBM is named for the fact that the cancerous cells have properties of support cells in the brain called glial cells. Rather than simply growing in a single tumor mass, GBM cells tend to migrate throughout the brain, making it difficult to remove them surgically. As the cells spread and multiply, they also tend to become resistant to radiation and chemotherapy.

"Interventions to control the spreading of glioblastoma multiforme have the potential to slow the clinical course of the disease and improve overall survival rates," says Jane Fountain, Ph.D., a program director at NIH's National Institute of Neurological Disorders and Stroke (NINDS). NINDS funded the new study through an initiative that encourages research on why brain tumor cells are so highly invasive and how to therapeutically target these cells.

The study's senior author is Susann Brady-Kalnay, Ph.D., a neuroscientist at Case Western Reserve University in Cleveland and an expert on the development of the retina. For years, she has studied how cells migrate to their proper places in the developing retina. In particular, she studied how this process is regulated by cell adhesion molecules proteins at a cell's surface that can keep the cell stuck to its surroundings, or help the cell move. She has shown that a cell adhesion molecule called PTPmu is required for retinal cell migration. Investigating the role of PTPmu in GBM dispersal was a logical extension, she says.

"We know that c
'/>"/>

Contact: Daniel Stimson
nindspressteam@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pitt researchers harness carbon nanomaterials for drug delivery systems, oxygen sensors
2. Microsoft Rogue Internet Pharmacy Problem Fixed? Not So Fast, Say Researchers
3. Researchers identify potential new avenue to attack cancer
4. Researchers find alcoholics display abnormal brain activity when processing facial expressions
5. UT Southwestern researchers launch study into search-and-destroy antigen for deadly skin cancer
6. Researchers Produce First Nationwide Study of Homeless in ERs
7. Yerkes researchers propose ambitious new strategies for AIDS vaccine research
8. Researchers Identify New Method to Selectively Kill Metastatic Melanoma Cells
9. Researchers identify new method to selectively kill metastatic melanoma cells
10. Researchers effectively treat tumors with use of nanotubes
11. Fox Chase researchers identify differences in treatments and outcomes of patients with second primary lung cancers versus those with one primary lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... Summer is ... hot spots.”* Add to that a particularly long, dry and hot 2015 summer season ... host and fresh water advocate Sharon Kleyne will discuss the 2015 summer season and ...
(Date:7/30/2015)... ... July 30, 2015 , ... HEALTHCAREfirst , the leading provider of cloud-based ... it is hosting a free webinar detailing the 2016 proposed rule from CMS for ... former Vice President of Regulatory Affairs for the National Association for Home Care and ...
(Date:7/30/2015)... Rosa, CA (PRWEB) , ... July 30, 2015 , ... At the presentation of the ... of discussion was focused on research presented by the Journal of Arthroplasty pertaining ... tasks – like driving. , Results of the study confirm what Santa Rosa ...
(Date:7/30/2015)... ... July 30, 2015 , ... Diagnotes, ... and reporting for reimbursement from the Centers for Medicare & Medicaid Services (CMS) ... providers are experimenting with manual data capture or, in many cases, just deciding ...
(Date:7/30/2015)... ... ... Addictions Training Institute has announced the launch of a fully ... Abuse Counselors. , "We are thrilled to be launching Addictions Training Institute,” said Ron ... and Drug Counselors nationwide. We are excited to be helping fill this need ...
Breaking Medicine News(10 mins):Health News:Fresh Water Advocate Sharon Kleyne Warns to Be Extra Cautious About Dry Eye “Hot Spot” Cities In Hot Dry Summer of 2015 2Health News:Fresh Water Advocate Sharon Kleyne Warns to Be Extra Cautious About Dry Eye “Hot Spot” Cities In Hot Dry Summer of 2015 3Health News:HEALTHCAREfirst Announces Home Health Industry Regulatory Review Webinar 2Health News:SRO Surgeon Dr. Nathan Ehmer Backs Up Latest Study That Total Hip Replacement Surgery Patients Are Resuming Normal Activities Sooner 2Health News:SRO Surgeon Dr. Nathan Ehmer Backs Up Latest Study That Total Hip Replacement Surgery Patients Are Resuming Normal Activities Sooner 3Health News:Diagnotes Announces Expansion of its Mobile Healthcare Communication System to Include Chronic Care Management Reimbursement Support 2Health News:Diagnotes Announces Expansion of its Mobile Healthcare Communication System to Include Chronic Care Management Reimbursement Support 3Health News:Addictions Training Institute Announces New Online Certificate Program for Alcohol and Drug Counselors 2
... . , Loss of thinking power is a ... resulted in a budding industry for brain training products ... which in 2007 generated $80 million in the United ... simple: participants must complete a series of daily exercises such ...
... first time that maintenance therapy with the novel antibody, ... improves progression-free survival in patients with stage III-IV indolent ... Langone Medical Center, lead author of a recent study ... of Clinical Oncology . , In a study, sponsored ...
... 2009, from 8:30 to 9:30 AM in Room 337 CLEVELAND, ... channels and GPCRs (G-protein coupled receptors) - key to drug ... its expanding line of services and reagents at booth 3056 ... Maryland. ChanTest,s growing catalog, comprising 86 ion channel and 48 ...
... might offer protection , , TUESDAY, March 10 (HealthDay News) -- A ... faced more than twice the risk of prostate cancer as those ... cancer in the study was slightly lower in men ... to a report in the March 10 online issue of the ...
... crafted a gene circuit that permits precise tuning of a ... for more accurate analysis of the gene,s role in normal ... achieved by installing a negative feedback loop in the synthetic ... electronics, a team led by scientists at The University of ...
... annual PROJECT HEALTHY LIVING, sponsored by WXYZ-TV/Channel 7, ... March 16 through Thursday, May 14 at more than ... metro Detroit counties. Project Healthy Living provides free or ... Free tests at all sites include blood pressure, height and ...
Cached Medicine News:Health News:Can mental training games help prevent Alzheimer's? 2Health News:Study shows that maintenance rituximab is useful for advanced indolent lymphoma 2Health News:ChanTest to Highlight Expanded Ion Channel and GPCR Services and Cell Lines, Including FDA Critical Path Safety Profiling Tools at ToxExpo, Booth 3056 2Health News:ChanTest to Highlight Expanded Ion Channel and GPCR Services and Cell Lines, Including FDA Critical Path Safety Profiling Tools at ToxExpo, Booth 3056 3Health News:Folic Acid Supplements Raise Prostate Cancer Risk 2Health News:Folic Acid Supplements Raise Prostate Cancer Risk 3Health News:Synthetic gene circuit allows precise dosing of gene expression 2Health News:Synthetic gene circuit allows precise dosing of gene expression 3Health News:Project Healthy Living to be Held March 16 to May 14th 2
(Date:7/29/2015)... 29, 2015  According to data released today by ... average monthly Medicare Part D premium is expected to ... was originally projected, the Pharmaceutical Care Management Association (PCMA) ... to be a bright spot in American health care. ... region and using cutting edge, cost-saving tools like pharmacy ...
(Date:7/29/2015)... July 29, 2015  Ascendis Pharma A/S (Nasdaq: ... its innovative TransCon technology to address significant unmet medical ... call on July 30, 2015, at 9:00 a.m. Eastern ... 2 pediatric study of once-weekly TransCon Growth Hormone. The ... results before the market opens on July 30, 2015. ...
(Date:7/29/2015)... July 29, 2015 Unilife Corporation (NASDAQ: ... manufacturer and supplier of injectable drug delivery systems, ... of instant patch pumps for insulin. ... insulin pump that does not require filling or ... and pre-assembled like an insulin pen, only three ...
Breaking Medicine Technology:Ascendis Pharma A/S to Report Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone and Host Conference Call on Thursday, July 30, 2015 at 9:00 a.m. Eastern Time 2Unilife Introduces World's First Instant Patch Pump for Insulin 2Unilife Introduces World's First Instant Patch Pump for Insulin 3Unilife Introduces World's First Instant Patch Pump for Insulin 4
... Respiratory Products, ,Westmed designs, manufacturers and ... and Respiratory professionals. Our mission is to ... clinician's ability to deliver quality medical care ... line. , ,Our web site is ...
... medication nebulizer achieves optimum lung penetration for ... range is 1.04-1.10 µ at 6-8 LPM. ... outlet., ,As the world leader in ... the assurance of proven technology by offering ...
... inhalers., ,ACE ensures prompt, effective delivery ... versatile design allows it to be used ... an endotracheal airway or resuscitation bag and ... be used in conjunction with an incentive ...
... medication as well as humidification, try Flo-Mist™., ... high volume, continuous medication nebulizer (CMN), engineered ... Its 200 ml reservoir and jet flow ... of nebulized medication delivery at 25 ml/hr. ...
Medicine Products: