Navigation Links
NIH researchers find new clues about aging
Date:6/13/2011

National Institutes of Health researchers have identified a new pathway that sets the clock for programmed aging in normal cells. The study provides insights about the interaction between a toxic protein called progerin and telomeres, which cap the ends of chromosomes like aglets, the plastic tips that bind the ends of shoelaces.

The study by researchers from the National Human Genome Research Institute (NHGRI) appears in the June 13, 2011 early online edition of the Journal of Clinical Investigation.

Telomeres wear away during cell division. When they degrade sufficiently, the cell stops dividing and dies. The researchers have found that short or dysfunctional telomeres activate production of progerin, which is associated with age-related cell damage. As the telomeres shorten, the cell produces more progerin.

Progerin is a mutated version of a normal cellular protein called lamin A, which is encoded by the normal LMNA gene. Lamin A helps to maintain the normal structure of a cell's nucleus, the cellular repository of genetic information.

In 2003, NHGRI researchers discovered that a mutation in LMNA causes the rare premature aging condition, progeria, formally known as known as Hutchinson-Gilford progeria syndrome. Progeria is an extremely rare disease in which children experience symptoms normally associated with advanced age, including hair loss, diminished subcutaneous fat, premature atherosclerosis and skeletal abnormalities. These children typically die from cardiovascular complications in their teens.

"Connecting this rare disease phenomenon and normal aging is bearing fruit in an important way," said NIH Director Francis S. Collins, M.D., Ph.D., a senior author of the current paper. "This study highlights that valuable biological insights are gained by studying rare genetic disorders such as progeria. Our sense from the start was that progeria had a lot to teach us about the normal aging process and
'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Routine screening for autism not needed: McMaster researchers
2. Researchers work to turn back the clock on bone-producing stem cells
3. U-M researchers advocate national strategic approach to therapeutic cancer vaccines
4. Rhode Island and Miriam researchers say patient gender may influence nuclear stress test referrals
5. Researchers discover biochemical weakness of malaria parasite -- vaccine to be developed
6. Researchers find that inhibiting microRNAs may help prevent degenerative eye disorders
7. Calorie-burning brown fat is a potential obesity treatment, researchers say
8. City of Hope researchers to present rectal cancer, palliative care, benchmarking studies at ASCO
9. U of Alberta researchers hoping to stop heart disease in cancer patients before it starts
10. U of A researchers hope to stop heart
11. UofL researchers uncover mechanism in saliva production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... new study challenges the widely held belief that light drinking ... analyzed more than 50 studies that examined drinking habits and ... that those with a form of a gene tied to ... affects how a person,s body breaks down alcohol, resulting in ... variant has been shown to lead to lower drinking over ...
(Date:7/11/2014)... Recent research findings regarding Fourth Phase Water are ... water affects human bodies. That was the conclusion of the ... on the Sharon Kleyne Hour Power of Water radio show ... PhD, is a Professor of Bioengineering at the University of ... (Ebner & Sons, 2013). , “Fourth Phase Water,” ...
(Date:7/11/2014)... Alliance Labs announced that they will ... Ed Begley Jr, airing later this year 2014, via ... this episode, Innovations will explore DocuSol® Kids, a mini-enema ... polyethylene glycol base designed to give adolescents general constipation ... as a hyperosmotic laxative by drawing water into the ...
(Date:7/11/2014)... Re-tearing a repaired knee Anterior Cruciate Ligament ... being presented today at the American Orthopaedic Society for ... identification and patient education regarding modifiable risk factors may ... , “Our research suggests that a few risk factors ... utilized may point to the possibility of re-injury,” said ...
(Date:7/11/2014)... SEATTLE, WA Re-tearing a repaired knee Anterior Cruciate ... study being presented today at the American Orthopaedic Society ... and patient education regarding modifiable risk factors may minimize ... "Our research suggests that a few risk factors such ... may point to the possibility of re-injury," said lead ...
Breaking Medicine News(10 mins):Health News:A Little Alcohol May Not Be Good for Your Heart After All 2Health News:Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour 2Health News:Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour 3Health News:Alliance Labs & DocuSol® to be Featured in Upcoming Episode of Innovations 2Health News:New Study May Identify Risk Factors for ACL Re-injury 2
... are soul sisters, says University of Illinois professor Constance ... pregnant and deliver babies that become the center of ... feel defeated and alone. Shapiro,s new book When ... that by providing a sisterhood of survivors who have ...
... more easily diagnosed and that its effects may be more ... in The FASEB Journal ( http://www.fasebj.org ), scientists ... and have discovered that drugs which affect the methylation state ... of drug is already being used in some cancer treatments. ...
... and shampoos, for instance, to breast development, , THURSDAY, ... in a wide range of consumer products may lead ... their risk for health problems later in life, U.S. ... -- phenols, phthalates and phytoestrogens -- are known as ...
... , ... is a great travel booking website for the vacationer who plans in advance, looking for ... a last-minute specials and deals. , ... Los Angeles, CA (PRWEB) April 8, 2010 -- SVH Tours & Travel, a ...
... prescription drugs , THURSDAY, April 8 (HealthDay News) -- Medical ... included -- are poorly informed about herbal medicines and that ... misplaced, according to a new survey. , The survey was ... and Therapeutics Bulletin , which published the results online April ...
... Thomas Mower Sr., Chairman of ... in the growth and success of Sportsmen for Fish and Wildlife (SFW), according to Founder Don ... Salt Lake City (PRWEB) April ... of the Utah Jazz, have been key players in the growth and success of Sportsmen for ...
Cached Medicine News:Health News:The Scarlet I: Infertility survivors lend voices to U of I prof's new book 2Health News:New study of autism reveals a 'DNA tag' (methylation) amenable to treatment 2Health News:Chemicals in Beauty Products Tied to Early Puberty in Girls 2Health News:Agency Pioneer SVH Tours & Travel Launches AppleSpecials.com, New Travel Booking Web Site that Showcases First-Hand Videos and Last Minute Specials 2Health News:Agency Pioneer SVH Tours & Travel Launches AppleSpecials.com, New Travel Booking Web Site that Showcases First-Hand Videos and Last Minute Specials 3Health News:Insight on Herbals Eludes Doctors, Patients Alike 2Health News:Thomas E. Mower And Karl Malone Instrumental To Success Of Sportsmen For Fish And Wildlife Organization 2Health News:Thomas E. Mower And Karl Malone Instrumental To Success Of Sportsmen For Fish And Wildlife Organization 3Health News:Thomas E. Mower And Karl Malone Instrumental To Success Of Sportsmen For Fish And Wildlife Organization 4
(Date:7/10/2014)... , July 10, 2014   Ventana Medical ... today announced it has entered into an agreement with ... operates as EMD Serono in the United ... to collaborate with Merck KGaA,s biopharmaceutical division on the ... an undisclosed target using Ventana,s proprietary diagnostic assays. In ...
(Date:1/15/2014)... Jan. 15, 2014 Sono-Tek Corporation (OTC BB: SOTK) today ... 30, 2013, compared to sales of $2,202,000 for the prior ... this quarter has also shown growth over the preceding quarter,s ... of this fiscal year. Markets that experienced sales increases over ...
(Date:1/15/2014)... today announced it has established a relief fund ... that has gripped much of the nation. AARP and its ... support these emergency relief efforts AARP and AARP Foundation will ... to $500,000 in aid. The matching program will be administered ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
Full automatic, ready-to-use strip washer....
MultiWash Advantage is a versatile microplate washer engineered for reliability. It is designed for lab environments to help streamline their daily processes....
Synchron Hemoglobin A1c (HbA1c) utilizes two unique cartridges, Hb and A1c, to determine HbA1c concentration as a percentage of total hemoglobin....
... HbA1c Testing , Monoclonal antibody ... precision , Correlation study shows 99% agreement ... you can count on a CV ... , National Glycohemoglobin Standardization Program (NGSP) certified ...
Medicine Products: