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NIH multicenter AIDS cohort study commemorates 25 years of discovery
Date:5/6/2009

he amount of HIV in bloodand progression of HIV disease
  • The link between low numbers of certain immune cells called CD4 T cells in the blood and progression to clinical AIDS
  • The central role of immune activation in the origin and development of HIV disease
  • Identifying unique features of long-term non-progressors (people infected with HIV whose bodies naturally limit viral replication) and people with genetic resistance to the virus
  • How to best manage the care and treatment of people with HIV, from preventive care for Pneumocystis pneumonia to antiretroviral therapy
  • The epidemiology of the virus that causes Kaposi's sarcoma, an AIDS-defining cancer, in HIV-infected patients
  • The interaction between aging and HIV infection
  • The epidemiology of major diseases that occur in conjunction with HIV/AIDS, including diseases of the heart, liver, kidneys and brain and certain cancers

    Since the study's inception in April 1984, the MACS has cumulatively enrolled nearly 7,000 men who have sex with men. Today, 2,525 men participate in the study, the others having diedusually from AIDSor dropped out of the study. About half of the current participants are infected with HIV, and nearly 90 percent of that group takes antiretroviral therapy.

    More than 200 investigators and staff belong to the MACS collaborative research team. Through behavioral questionnaires and the collection of biological specimens, study staff gather 8,500 separate pieces of information from each participant every six months, generating a gold mine of data and specimens for investigation. The scientific community and the public can access much of the MACS data, and study investigators actively pursue collaborations with outside researchers who propose studies of high scientific quality to the MACS leadership.

    Along with Dr. Fauci, the anniversary event's guest speakers will include Jeffrey Crowley, director of the White House Office of
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  • Contact: Laura Sivitz
    sivitzl@niaid.nih.gov
    301-402-1663
    NIH/National Institute of Allergy and Infectious Diseases
    Source:Eurekalert

    Page: 1 2 3

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