Navigation Links
NIH multicenter AIDS cohort study commemorates 25 years of discovery
Date:5/6/2009

The longest U.S. study of people with HIV/AIDS will be honored at a 25th anniversary commemoration on May 12, 2009, at the Carnegie Institution for Science in Washington, D.C. The Multicenter AIDS Cohort Study (MACS) has significantly contributed to the scientific understanding of HIV, AIDS and the effects of antiretroviral therapy through more than 1,000 publications, many of which have guided public health policy and the clinical care of people with HIV. MACS investigators prospectively study the natural and treated history of HIV infection in thousands of homosexual and bisexual men at sites in Baltimore, Chicago, Pittsburgh and Los Angeles.

Guests will hear a keynote address by Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH. NIAID and the National Cancer Institute developed the MACS and have been its principal sponsors.

"The MACS has been one of the most rigorous and productive epidemiologic HIV/AIDS studies in history," says Dr. Fauci. "The MACS led key studies that linked sexual behavior to HIV transmission, determined the median period of time between HIV infection and the onset of AIDS, showed that an imbalance of T-cell types precedes AIDS, and made a multitude of other pivotal discoveries that advanced HIV/AIDS research."

An extraordinary characteristic of the MACS is its 25 years of behavioral and biological data and specimens from men who have sex with men, before and after they became infected with HIV, before and after they were diagnosed with AIDS, and before and after they began highly active antiretroviral therapyalong with data from a control group of same-aged, HIV-free men who have sex with men. Comparing these before-and-after specimens and data from HIV-infected and uninfected individuals has yielded numerous seminal discoveries, including:

  • How best to diagnose HIV infection
  • The direct relationship between viral loadthe amount of HIV in bloodand progression of HIV disease
  • The link between low numbers of certain immune cells called CD4 T cells in the blood and progression to clinical AIDS
  • The central role of immune activation in the origin and development of HIV disease
  • Identifying unique features of long-term non-progressors (people infected with HIV whose bodies naturally limit viral replication) and people with genetic resistance to the virus
  • How to best manage the care and treatment of people with HIV, from preventive care for Pneumocystis pneumonia to antiretroviral therapy
  • The epidemiology of the virus that causes Kaposi's sarcoma, an AIDS-defining cancer, in HIV-infected patients
  • The interaction between aging and HIV infection
  • The epidemiology of major diseases that occur in conjunction with HIV/AIDS, including diseases of the heart, liver, kidneys and brain and certain cancers

Since the study's inception in April 1984, the MACS has cumulatively enrolled nearly 7,000 men who have sex with men. Today, 2,525 men participate in the study, the others having diedusually from AIDSor dropped out of the study. About half of the current participants are infected with HIV, and nearly 90 percent of that group takes antiretroviral therapy.

More than 200 investigators and staff belong to the MACS collaborative research team. Through behavioral questionnaires and the collection of biological specimens, study staff gather 8,500 separate pieces of information from each participant every six months, generating a gold mine of data and specimens for investigation. The scientific community and the public can access much of the MACS data, and study investigators actively pursue collaborations with outside researchers who propose studies of high scientific quality to the MACS leadership.

Along with Dr. Fauci, the anniversary event's guest speakers will include Jeffrey Crowley, director of the White House Office of National AIDS Policy; Christopher H. Bates, acting director of the Office of HIV/AIDS Policy at the U.S. Department of Health and Human Services; Gregg Gonsalves, an internationally renowned HIV activist; Shannon Hader, M.D., M.P.H., Director of the District of Columbia HIV/AIDS Administration; a participant from each of the four MACS sites; and Richard Kaslow, M.D., M.P.H., a MACS founding investigator. Potomac Fever, the a cappella ensemble of the Gay Men's Chorus of Washington, D.C., will provide entertainment.

The event will take place from 7:00 pm to 9:30 pm on May 12 in the Carnegie Institution for Science at 1530 P St. NW in Washington, D.C.


'/>"/>

Contact: Laura Sivitz
sivitzl@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Johns Hopkins leads first 12-patient, multicenter domino donor kidney transplant
2. Three Italian Multicenter Studies Report High (>70%) Rates of Complete Remission (CR) Utilizing Zevalin Radio-Immunotherapy (RIT) in Treatment of Newly Diagnosed or Relapsed or Refractory Non-Hodgkins Lymphoma
3. Large multicenter study suggests new genetic markers for Crohns disease
4. Minimally invasive fibroid treatment fares well in multicenter trial
5. CT Angiography Highly Accurate: Multicenter Trials Show
6. CT angiography highly accurate, multicenter trials show
7. Medical University of South Carolina Leads Multicenter Study Evaluating Biliary Sphincter Disorder
8. Decreasing access to cigarettes for youth in the Minnesota Adolescent Community Cohort Study
9. Ninety-one Percent of BARACLUDE(R) (entecavir) Treated Patients in a Four-Year Cohort Demonstrated Virologic Suppression to Undetectable Levels
10. Pitt study on alcohol reveals drinkers not only zone out -- but also are unaware that they do
11. ABCs and No Skinned Knees: Study Reveals Various Barriers to Physical Activity in Child Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... February 27, 2017 , ... POUGHKEEPSIE, N. Y. – Peer-reviewed guidelines from the ... studies, the Center for Disease Control ( CDC ) and Infectious Diseases Society of ... Liegner, M.D. has compiled into a single volume a compelling argument that the disease ...
(Date:2/27/2017)... ... February 27, 2017 , ... New Jersey ranks among the top five ... genders. And the need for advanced services is growing. , Project WE vs ... program, in collaboration with their non-profit partners in their fight against cancer and in ...
(Date:2/26/2017)... ... February 26, 2017 , ... LatitudeC Baby Products, ... today announced it would be offering some it’s exclusive product line to the ... quality and unique baby clothing/feeding products, will team up with AMAZON to distribute ...
(Date:2/26/2017)... (PRWEB) , ... February 26, 2017 , ... ... Parkinson’s disease (PD) in persons with a specific LRRK2 mutation, according to a ... , Previous studies have provided evidence of a link between pesticides and incidence ...
(Date:2/24/2017)... NJ (PRWEB) , ... February 24, 2017 , ... ... that provides business development, education, networking and recognition opportunities as well as advocacy ... Bell Works in Holmdel, NJ on February 23. The Council's Innovation Forecast ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... 27, 2017 Leading Countries, Technologies and Companies ... expected to grow at a CAGR of 8.9% from 2016-2021 and ... at a CAGR of 9.1% from 2016 to 2027. The market ... ... benefit you Read on to discover how you can exploit ...
(Date:2/27/2017)... and PETACH TIKVAH, Israel , Feb. ... BCLI), a leading developer of adult stem cell technologies ... June S. Almenoff , M.D., Ph.D., FACP, and ... of Directors.  "Dr. Almenoff and Mr. ... come at an exciting time for our company," said ...
(Date:2/27/2017)... Feb 27, 2017 The Dutch ... NATO for use at the security level RESTRICTED. The solution ... NATO organization for the communication of classified information. ... Sectra and Samsung ... an eavesdrop-secure smartphone solution. Sectra Tiger/R is developed by Sectra ...
Breaking Medicine Technology: