Navigation Links
NIH-led scientists discover HIV antibody that binds to novel target on virus
Date:9/3/2014

WHAT:

An NIH-led team of scientists has discovered a new vulnerability in the armor of HIV that a vaccine, other preventive regimen or treatment could exploit. The site straddles two proteins, gp41 and gp120, that jut out of the virus and augments other known places where broadly neutralizing antibodies (bNAbs) bind to HIV. This newly identified site on the viral spike is where a new antibody found by the scientists in an HIV-infected person binds to the virus. Called 35O22, the antibody prevents 62 percent of known HIV strains from infecting cells in the laboratory and is extremely potent, meaning even a relatively small amount of it can neutralize the virus.

Following their discoveries, the scientists found that 35O22-like antibodies were common in a group of HIV-infected people whose blood contained antibodies that potently neutralized a broad array of HIV strains. According to the researchers, this suggests that it might be easier for a vaccine to elicit 35O22 than some other known bNAbs, which are less common.

Since 35O22 binds only to forms of the viral spike that closely resemble those that naturally appear on HIV, the scientists believe a vaccine that elicits 35O22-like antibodies would need to mimic the natural shape of the spike as closely as possible. This would require a different approach than that used in many previous experimental HIV vaccines, which have included just parts of the viral spike rather than a structure that looks like the entire native viral spike.

In addition, the researchers report, the HIV strains that 35O22 neutralizes complement strains neutralized by other bNAbs. This suggests that eliciting or combining 35O22 with a few other bNAbs in a vaccine or a prevention or treatment regimen could likely neutralize the vast majority of HIV strains found around the globe, according to the scientists.


'/>"/>

Contact: Laura S. Leifman
laura.sivitz@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. CU scientists discovery could lead to new cancer treatment
2. Scientists Find Differences in Brains of Those With Dyslexia
3. Scientists Rewrite Bad Memories in Mice
4. Scientists map the editing marks on fly, worm, human genomes
5. Scripps Research Institute scientists link alcohol-dependence gene to neurotransmitter
6. Kessler Foundation scientists study impact of cultural diversity in brain injury research
7. Scientists Spot Genetic Clues to Crohns Disease
8. Leading scientists call for a stop to non-essential use of fluorochemicals
9. Scientists Say Blood Sodium Could Predict Mesothelioma Outcomes, According to Surviving Mesothelioma
10. Illinois scientists work with World Health Organization to fortify condiments, seasonings
11. Virus, zebrafish enable scientists to map the living brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... A new vaccine created to fight an illness similar ... livestock and even humans from similar brain infections, researchers ... from becoming infected by the incurable brain disorder known ... the Dec. 21 online edition of the journal ... infectious particles known as prions that go rogue. ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Super Saturday, ... Friday this year as the busiest day in the ... retailers, The Grass Station had a steady pre-Christmas stream ... gifts, this past Saturday. , “I definitely intend to ... Robert, a Denver resident who was enjoying The Grass ...
(Date:12/22/2014)... 2014 Give a loved one the ... of health and vitality. , For a limited time, ... anti-aging formulas in special Holiday Wellness gift packages at ... , Each bottle contains cutting-edge, proven nutritional support for ... as well as we age. , Joint ...
(Date:12/22/2014)... Pasadena, CA (PRWEB) December 22, 2014 ... is now offering consultations for sleep apnea. Drowsy drivers ... crashes than drivers who are well-rested, and some experts ... on the roads as intoxicated drivers. Unfortunately, millions of ... to the American Academy of Sleep Medicine, about 18 ...
(Date:12/22/2014)... December 22, 2014 TheHardwareCity.com now stocks ... with many useful features. Customers of the large online ... the new gloves delivered to their home or workplace ... hand tools that incorporate heavy duty magnets, which make ... allows workers to store metal parts on the back ...
Breaking Medicine News(10 mins):Health News:Vaccine for Deer Against 'Mad Cow'-Like Illness Shows Promise 2Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2
... Society of Corporate Compliance and Ethics and Health ... critical time when the public, government leaders and ... bonus reforms, it appears that there is relatively ... according to a recent survey conducted by the ...
... 28 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical, Inc. ("China ... CSKI ), a leading fully integrated pharmaceutical company in ... Mr. Hubert Cooleman, Flemish economic representative for the North ... Ren Medical Company ("TDR"), a wholly-owned subsidiary of China ...
... Americans Suffer in Silence ... From Constipation(1): From Connecticut ... -NEW YORK, May 28 While it might not ... comfortable talking about constipation, the results of a new ... topic really is: In fact, while more than ...
... 28 Air Products (NYSE: APD ) ... John E. McGlade will be presenting at the Goldman ... June 4, 2009, at 8:00 a.m. EDT. An audio ... Products, Investor Relations web site at www.airproducts.com/Invest/PresentationSummary.htm . ...
... ESA,s next Earth Explorer, SMOS, has just passed the all-important ... up the mission are in place for launch later this ... to the Plesetsk Cosmodrome in northern Russia. , The Flight ... the mission elements are in order and ready for launch. ...
... 28 Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT ... and commercialization of proprietary products that address important therapeutic ... Glenn A. Oclassen, President & Chief Executive Officer, is ... Science Conference in New York City on Wednesday, June ...
Cached Medicine News:Health News:Survey Data Reveals Little Connection between Executive Compensation, Employee Bonuses and Business Ethics and Compliance 2Health News:Survey Data Reveals Little Connection between Executive Compensation, Employee Bonuses and Business Ethics and Compliance 3Health News:China Sky One Medical, Inc. Welcomes Commercial Counselor from Belgium; Looks for Business Alliance with European Companies 2Health News:China Sky One Medical, Inc. Welcomes Commercial Counselor from Belgium; Looks for Business Alliance with European Companies 3Health News:Guess What Most Americans Don't Want to Talk About (Hint: It's Not Sex!) 2Health News:Guess What Most Americans Don't Want to Talk About (Hint: It's Not Sex!) 3Health News:Guess What Most Americans Don't Want to Talk About (Hint: It's Not Sex!) 4Health News:SMOS ready to ship to launch site 2Health News:Transcept Pharmaceuticals to Present at Needham Life Sciences Conference on June 10, 2009 2Health News:Transcept Pharmaceuticals to Present at Needham Life Sciences Conference on June 10, 2009 3
(Date:12/22/2014)... Apnea Sciences ( www.apneasciences.com ) announced it ... Aliso Viejo , California.  Jimmy Fallon , ... and worldwide expansion, a new facility with expanded infrastructure ... snore cure have exceeded our expectations and thus required ... in 23 countries and will be increasing to 39 ...
(Date:12/22/2014)... Tenn. , Dec. 22, 2014   TRU-D ... automated, no-touch UV disinfection robot, announced today that the ... Schedule contract through November 2019.   This ... rapidly engage all levels of government purchasers, including Department ... as well as Homeland Security contacts purchasing solutions for ...
(Date:12/22/2014)... a privately-held medical products and technologies company, today announced ... Officer of the company, effective December 22, 2014. ... Board of Directors of ConvaTec thanks Mr. Berger for ... years," said Magnus Lundberg , the Chairman of ... company is well positioned for the future."  The company ...
Breaking Medicine Technology:TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2
... NEW YORK, Nov. 21, 2011 Reportlinker.com announces ... in its catalogue: The 2011 ... and Sales Forecasts by Country ... presents a detailed analysis of the Vibrio diagnostics ...
... announces that a new market research report is ... Automation Technologies, Products and Markets ... INTRODUCTION ... enactment of the Patient Protection and Affordable Care ...
Cached Medicine Technology:The 2011 Vibrio Diagnostics Market: US, Europe, Japan Test Volume and Sales Forecasts by Country 2The 2011 Vibrio Diagnostics Market: US, Europe, Japan Test Volume and Sales Forecasts by Country 3The 2011 Vibrio Diagnostics Market: US, Europe, Japan Test Volume and Sales Forecasts by Country 4Medical Automation Technologies, Products and Markets 2Medical Automation Technologies, Products and Markets 3Medical Automation Technologies, Products and Markets 4Medical Automation Technologies, Products and Markets 5Medical Automation Technologies, Products and Markets 6Medical Automation Technologies, Products and Markets 7Medical Automation Technologies, Products and Markets 8Medical Automation Technologies, Products and Markets 9Medical Automation Technologies, Products and Markets 10Medical Automation Technologies, Products and Markets 11Medical Automation Technologies, Products and Markets 12Medical Automation Technologies, Products and Markets 13Medical Automation Technologies, Products and Markets 14Medical Automation Technologies, Products and Markets 15
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: