Navigation Links
NIH-led scientists discover HIV antibody that binds to novel target on virus
Date:9/3/2014

WHAT:

An NIH-led team of scientists has discovered a new vulnerability in the armor of HIV that a vaccine, other preventive regimen or treatment could exploit. The site straddles two proteins, gp41 and gp120, that jut out of the virus and augments other known places where broadly neutralizing antibodies (bNAbs) bind to HIV. This newly identified site on the viral spike is where a new antibody found by the scientists in an HIV-infected person binds to the virus. Called 35O22, the antibody prevents 62 percent of known HIV strains from infecting cells in the laboratory and is extremely potent, meaning even a relatively small amount of it can neutralize the virus.

Following their discoveries, the scientists found that 35O22-like antibodies were common in a group of HIV-infected people whose blood contained antibodies that potently neutralized a broad array of HIV strains. According to the researchers, this suggests that it might be easier for a vaccine to elicit 35O22 than some other known bNAbs, which are less common.

Since 35O22 binds only to forms of the viral spike that closely resemble those that naturally appear on HIV, the scientists believe a vaccine that elicits 35O22-like antibodies would need to mimic the natural shape of the spike as closely as possible. This would require a different approach than that used in many previous experimental HIV vaccines, which have included just parts of the viral spike rather than a structure that looks like the entire native viral spike.

In addition, the researchers report, the HIV strains that 35O22 neutralizes complement strains neutralized by other bNAbs. This suggests that eliciting or combining 35O22 with a few other bNAbs in a vaccine or a prevention or treatment regimen could likely neutralize the vast majority of HIV strains found around the globe, according to the scientists.


'/>"/>

Contact: Laura S. Leifman
laura.sivitz@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. CU scientists discovery could lead to new cancer treatment
2. Scientists Find Differences in Brains of Those With Dyslexia
3. Scientists Rewrite Bad Memories in Mice
4. Scientists map the editing marks on fly, worm, human genomes
5. Scripps Research Institute scientists link alcohol-dependence gene to neurotransmitter
6. Kessler Foundation scientists study impact of cultural diversity in brain injury research
7. Scientists Spot Genetic Clues to Crohns Disease
8. Leading scientists call for a stop to non-essential use of fluorochemicals
9. Scientists Say Blood Sodium Could Predict Mesothelioma Outcomes, According to Surviving Mesothelioma
10. Illinois scientists work with World Health Organization to fortify condiments, seasonings
11. Virus, zebrafish enable scientists to map the living brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... 2014 Insuranceragents.info has released a ... life insurance plan for vulnerable family members. , Life ... members. Providers in the family should always carry a ... hardships for the rest of the family. , ... can benefit more from temporary coverage or from a ...
(Date:10/1/2014)... and ATLANTA (PRWEB) October 01, 2014 ... security executive networking and relationship-marketing firm, announced ... Information Security Executive® and Project of the ... top-ranking decision makers representing organizations in financial ... Projects include large-scale technology endeavors that address ...
(Date:10/1/2014)... 2014 Between 23 million and 50 ... according to figures from the National Institutes of Health ... and many of them have something else in common: ... celiac disease. Gluten Free Therapeutics, makers of CeliVites ... celiac disease by publishing a series of blog posts ...
(Date:10/1/2014)... 2014 Scientists at the University of ... target immune system proteins has the power to knock ... details of the new study on their website. ... Researchers in the UWA School of Pathology and Laboratory ... mice with mesothelioma with promising results. , “A ...
(Date:10/1/2014)... Woodland Hills dental implants ... of dental specialists who treat full mouth implant cases ... Oviedo. Dr. Reshad of the Anacapa Dental Art Institute, ... two continents, will give a full-day presentation Oct. 4 ... , “These specialists want to improve their skills and, ...
Breaking Medicine News(10 mins):Health News:Life Insurance for Families - Clients Can Compare Affordable Rates Online! 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:New Mesothelioma Study Says Mice Cured by Immuntherapy “Cocktail”, Reports Surviving Mesothelioma 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 3Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 4
... Coverage Continues to Drop Even Before the,Economic Downturn in ... Exceeds the Combined,Population of 24 States Plus the District ... Bureau,s annual,report released today shows that the number of ... continued worsening of health,coverage for America,s workers., While ...
... study could explain why "daddy" and "mommy" are often ... be hard-wired to recognize certain repetition patterns. , ... British Columbia post-doctoral fellow Judit Gervain and a team ... of 22 newborns (2-3 days old) when exposed to ...
... 26 WaterPure,International, Inc. (the "Company" or "WaterPure") ... executed an amended Atmospheric Water,Generator (AWG) patent license ... of the original license. Under the previous agreement,WaterPure ... in the current,year. The revised terms now call ...
... both the SIRIUS and XM services on SIRIUS, Hits 1 SIRIUS channel 1 ... ... channel 24, NEW YORK, Aug. 26 SIRIUS XM ... Campaign to broadcast its "Just Stand Up" national,fundraising event live on Friday, September ...
... Sciences Inc. today,announced the development of their ... medical devices that release drugs at,constant rates ... has already been used,by Particles Sciences to ... polymeric materials often follows a burst/first-order kinetic ...
... of Alberta in Edmonton, Canada, shows thatfor womenthe caffeine advantage ... don,t drink coffee can get just as much of a ... a study in the latest edition of Nutrition Research ... you are hooked on caffeine or not, if you need ...
Cached Medicine News:Health News:Number of Uninsured Decreased in 2007 But Census Report Shows Growing Health Coverage Problems 2Health News:UBC scientist unveils secret of newborn's first words 2Health News:WaterPure International, Inc. and Everest Water Ltd. Revise Payment Terms of Patent License to Produce Water From Air 2Health News:SIRIUS XM Radio Joins Stand Up To Cancer Campaign with Live Broadcast of Star-Studded 'Just Stand Up' Fundraising Event on September 5 2Health News:SIRIUS XM Radio Joins Stand Up To Cancer Campaign with Live Broadcast of Star-Studded 'Just Stand Up' Fundraising Event on September 5 3Health News:SIRIUS XM Radio Joins Stand Up To Cancer Campaign with Live Broadcast of Star-Studded 'Just Stand Up' Fundraising Event on September 5 4Health News:Particle Sciences Develops Zero-Order-Release Combination Device Technology 2Health News:Java gives caffeine-naive a boost, too 2
(Date:9/30/2014)... 2014 Arbor Pharmaceuticals, LLC. - Product ... Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - Product Pipeline ... Arbor Pharmaceuticals, LLC.,s pharmaceutical research and development focus. ... current therapeutic developmental pipeline of Arbor Pharmaceuticals, LLC.,s, ... assessment by drug target, mechanism of action (MoA), ...
(Date:9/30/2014)...  Decision Resources Group finds that the Asia Pacific ... China , India , ... through 2023. Dental implant procedure volumes will grow as physicians are ... Other key findings from Decision Resources Group,s coverage of the ... , Dental implant penetration: Penetration of dental implants among the ...
(Date:9/30/2014)... , Sept. 30, 2014  Alimera Sciences, Inc. ... that specializes in the research, development and commercialization of ... a $25 million advance from Hercules Technology Growth Capital, ... is the second and final advance under the Loan ... United Kingdom , Alimera Sciences Limited, entered ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3Alimera Sciences Receives $25 Million Advance from Hercules Technology Growth Capital 2
... International Group, Ltd. ("Biosensors" or the "Company", Bloomberg: BIG ... marketer of innovative medical devices for interventional cardiology and ... third fiscal quarter (" Q3 FY12 ") and nine ... Q3 FY12 Performance Highlights: ...
... Misonix, Inc. (NASDAQ: MSON ), ... markets innovative therapeutic ultrasonic products worldwide for wound ... surgical and medical applications, today reported financial results ... ending December 31, 2011.  Michael A. McManus Jr., ...
Cached Medicine Technology:Biosensors Reports Continued Strong Sales and Earnings Growth in the Third Quarter of Fiscal Year 2012 2Biosensors Reports Continued Strong Sales and Earnings Growth in the Third Quarter of Fiscal Year 2012 3Biosensors Reports Continued Strong Sales and Earnings Growth in the Third Quarter of Fiscal Year 2012 4Biosensors Reports Continued Strong Sales and Earnings Growth in the Third Quarter of Fiscal Year 2012 5Biosensors Reports Continued Strong Sales and Earnings Growth in the Third Quarter of Fiscal Year 2012 6Misonix Reports a 29% and 24% Increase in Revenue for the Second Quarter and Six Months Fiscal 2012 Financial Results 2Misonix Reports a 29% and 24% Increase in Revenue for the Second Quarter and Six Months Fiscal 2012 Financial Results 3Misonix Reports a 29% and 24% Increase in Revenue for the Second Quarter and Six Months Fiscal 2012 Financial Results 4Misonix Reports a 29% and 24% Increase in Revenue for the Second Quarter and Six Months Fiscal 2012 Financial Results 5Misonix Reports a 29% and 24% Increase in Revenue for the Second Quarter and Six Months Fiscal 2012 Financial Results 6
Gently curved jaws with fine angled sharp tips for puncture and grasping the capsule. Round handle is excellent for precise finger tip control. Made in titanium....
Regular tip. 1 mm x 13 mm. Serrated. Insulated....
Colibri style with 1.5 mm long angled tip and 0.12 mm teeth. Serrated handles with polished finish....
Straight shafts with 4 mm jaws. Serrated handle with dull finish. Jaws straight....
Medicine Products: