Navigation Links
NIH launches effort to define markers of human immune responses
Date:8/11/2010

A new nationwide research initiative has been launched to define changes in the human immune system, using human and not animal studies, in response to infection or to vaccination. Six U. S.-based Human Immune Phenotyping Centers will receive a total of $100 million over five years to conduct this research.

Funding for the centers is provided by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Support for the first year of this initiative will come from the American Recovery and Reinvestment Act.

"Recognizing the differences in immune system activity before, during and after exposure to an infectious agent or vaccine will help in the development of safer, more effective therapeutics and vaccines," says NIAID Director Anthony S. Fauci, M.D. "This research effort also will contribute to the ongoing evolution in our ability to study the immune system."

Investigators will analyze samples from well-characterized groups, including children, the elderly and people with autoimmune diseases such as lupus. These groups represent diverse populations with respect to age, genetics, gender and ethnicity. The research teams will examine immune system elements of these populations before and after exposure to naturally acquired infections or to vaccines or vaccine components. The profile that will emerge of the body's response to vaccination will be based on the most sophisticated and comprehensive assays currently available. This will enable new approaches to examining vaccine safety, not just of individual vaccines but of the processes of immunization in general.

Their studies will focus on immune responses to vaccines against specific viruses and bacteria, such as influenza and pneumococcus, as well as to infection with West Nile virus. The investigators will take advantage of technological developments and advances in creating databases and developing mathematical models to identify and analyze the complex changes in immune profiles.

Each awardee will contribute to the establishment of a centralized infrastructure to collect, characterize and store human samples and analyze the large data sets that will be generated. Eventually, the centers will gather the information from this effort into a centralized Web-based database they will make available to the scientific community to promote and support human immunology research.

"This research effort represents a major expansion of efforts to define the principles of human immune regulation, instead of relying on findings from animal models that have limitations and cannot always be extrapolated to people," says Daniel Rotrosen, M.D., director of the Division of Allergy, Immunology and Transplantation at NIAID. "The knowledge gained also will improve our understanding of the range of vaccine responses in particular subpopulations, including newborns, young children, the elderly, patients taking immunosuppressive medications and those with underlying diseases of the immune system, such as allergy and autoimmune diseases."

The following six core institutions and principal investigators will participate in the inaugural program:

  • Baylor Research Institute, Dallas Jacques Banchereau, Ph.D.
  • Dana-Farber Cancer Institute, Boston Ellis Reinherz, M.D.
  • Emory University, Atlanta Bali Pulendran, Ph.D.
  • Mayo Clinic, Rochester, Minn. Gregory Poland, M.D.
  • Stanford University, Calif. Mark Davis, Ph.D.
  • Yale University, New Haven, Conn. David Hafler, M.D., and Erol Fikrig, M.D.

A portion of the funding for the centers will be dedicated to support smaller studies proposed by investigators outside the program, including pilot projects, the development of research resources and clinical studies.


'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. European Society of Cardiology launches heart-friendly cookery book
2. Springer launches Drug Delivery and Translational Research
3. GlassesUSA.com Launches Eyeglasses Refer-A-Friend Program
4. Flyer Printing Powerhouse, Taradel LLC, Launches Free West Coast Shipping Promotion
5. Search Technologies Launches FAST Search Server 2010 for SharePoint Quick-Start Program
6. Aesthetic Society Launches Project Beauty, NEW Consumer Website Covering All Things Beauty
7. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
8. Estetique Launches New Line of IPL Aesthetic Equipment
9. Publishing and Media Distribution Firm Launches Online Public Relations Kit for Businesses Seeking Free Publicity
10. Growandmake.com Launches New Sustainable Living Guides
11. Vera Bradley Launches National “Be Colorful” Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 19, 2017 , ... ... Thailand presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, ... Noppadon Pakprot, Deputy Governor for Tourism Products and Business at TAT said, “Thailand ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... this summer’s edition of “Vision & Hearing,” advocating for active, healthy lifestyles and ... on resources available for individuals with hearing impairments and shares the latest innovations ...
(Date:8/18/2017)... WV (PRWEB) , ... August 18, 2017 , ... ... financial consulting services and asset protection assistance to communities in North-Central West Virginia, ... provide critical services to at-risk boys in the area. , The Chestnut Mountain ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a Texas based ... area, is spearheading a regional charity campaign organized to provide support to Christina Upchurch ... of this year, Christina and her children returned from out of town to find ...
(Date:8/18/2017)... SAN DIEGO, CA & CARMEL, IN (PRWEB) , ... August 18, ... ... No. 3828 on its 36th annual list, the most prestigious ranking of the nation's ... ASH has been included in the exclusive Inc. 5000 ranking . This year’s ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... , Aug. 7, 2017  Endo International plc (NASDAQ: ... agreements to resolve virtually all known U.S. mesh product ... to resolve the known remaining U.S. claims at reasonable ... beginning in the fourth quarter of 2017 and continuing ... its second quarter 2017 results, the Company intends to ...
(Date:8/2/2017)... Calif. , Aug. 2, 2017 ... Continental Who,s Who as a Pinnacle Lifetime Professional ... the Key Account Manager at Turing Pharmaceuticals, AG. ... negotiations, troubleshooting and relationship building.                ... has more than 25 years of experience as ...
(Date:8/1/2017)... 2017   CerSci Therapeutics , a non-opioid drug ... , has received notice from the National Institute on ... (NIH) that it has been awarded a Direct-to-Phase II ... in 2017 with an additional $1,000,000 to follow in ... application of their lead non-opioid drug candidate CT-044 to ...
Breaking Medicine Technology: