Navigation Links
NIH grants to Children's Hospital will advance novel stem cell treatments for blood disorders
Date:2/16/2010

odel system for understanding how blood disorders develop. "Many blood diseases are difficult to study in patients, in terms of the exact mechanisms by which cells develop abnormally," said Weiss. "We will investigate iPSCs in models of two pediatric disorders, with the goal of using our improved knowledge of cell biology to devise treatments."

Weiss's group will focus on blood diseases associated with Down syndrome. Children with Down syndrome are at higher risk for transient myeloproliferative disorder, a precursor of leukemia, as well as for acute megakaryoblastic leukemia. Using animal models, the researchers will stimulate iPSCs to mimic disease processes seen in Down syndrome, in hopes of discovering ways to prevent these forms of leukemia.

A third goal of Weiss's project is to collect tissues from patients, then reprogram their cells into iPSCs and develop them into tissue banks for specific diseases. In this effort, his team will concentrate on a genetic blood disorder called Diamond Blackfan anemia.

Weiss's team at Children's Hospital will partner with scientists at two other institutions in the region: Pennsylvania State University, in State College, Pa., and the Coriell Institute for Medical Research, in Camden, N.J.

"The successful completion of these grants was in large part based on the recent establishment of the Human Embryonic Stem Cell Core at Children's Hospital," said Poncz. "These two grants illustrate the promising future that stem cell biology holds, not only for research purposes and for hematologic and oncologic disorders, but for a wide range of diseases that presently have suboptimal therapies. The future of stem cell therapy may be limited only by our imagination."


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. U.S. Labor Department Awards $10.1 Million for Safety and Health Training Grants
2. Sunesis Pharmaceuticals Reports New Option Grants Under NASDAQ Marketplace Rule 4350
3. American Cancer Society awards research grants to 109 investigators at 77 institutions nationwide
4. USAID Announces First Malaria Communities Program Grants
5. The Highmark Foundation Awards $580,000 in Highmark Healthy High 5 Grants to Four Non-Profit Organizations
6. KV Pharmaceutical Company Reports Results of Special Independent Committee Review of Stock Option Grants
7. FDA Grants Clearance to Langford IC Systems, Inc.
8. Dienst Custom Homes Grants Over 40 Wishes in Three Years
9. United Animal Nations Offers Financial Assistance Grants of up to $500 to Help Southern California Fire Victims Obtain Vet Care, Temporary Boarding for Pets
10. PA Health Department Awards Community Primary Care Challenge Grants
11. FDA Grants Kiadis Pharma Lead Product ATIR Orphan Drug Designation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... 24, 2015 Indiana Fiber Network, LLC ... Midwest Telecom of America, Inc. (MTA) has selected IFN ... Cory Childs, IFN Enterprise Sales Manager, fiber route diversity ... “IFN’s fiber transport provides MTA with the diverse fiber ... Tier 1 Internet and voice carriers located at Henry ...
(Date:5/24/2015)... May 24, 2015 ... CEO - The students were ... at the fourth annual A Day ... at Geneva National in Lake Geneva. ...     -Badger High School,         Jonathan Alfonso,         Bridget ...
(Date:5/23/2015)... FL (PRWEB) May 23, 2015 On Saturday, ... build a new playground for Branches Florida City exactly five ... former play space in 2010. , A large fire tore ... playground on May 23, 2010 in the middle of the ... The fire was later declared arson even though it is ...
(Date:5/23/2015)... Newport Beach, CA (PRWEB) May 23, 2015 ... Newport Beach, California, has just posted a new article ... ear gauge repair. As Dr Benvenuti explained in ... who wear enlarged plugs in their earlobes. , Known as ... into the earlobe hole, which Dr. Benvenuti said will eventually ...
(Date:5/23/2015)... 2015 On Wednesday, May 20, 2015, ... has been the target of a sophisticated cyberattack,” and ... company’s ongoing Information Technology (IT) security efforts in the ... The most notable attack on health insurers was reported ... nation’s second largest health insurer, revealed that they had ...
Breaking Medicine News(10 mins):Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:Dr. Benvenuti, a Plastic Surgeon in Newport Beach, CA, Posts New Article about Repairing Ear Gauges 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4
... cancer progresses quickly among old men. This results in a ... by this disease are more likely to die from some ... results in adverse side effects. But conservative treatment in case ... suggest that men 75 years or older may not benefit ...
... disorders like anorexia and bulimia which has initially haunted the ... affected //due to sheer peer pressure, families and friends. The ... The authors wanted to analyze the gap in the literature ... female adolescents. ,Such questions were seriously thought only ...
... Warner, the minister for National Health Service reform said ... order to be safe and stable.// Andrew Foster, the ... that various ingrained practices have to undergo a change. ... greater choice and allowing more hospitals to move to ...
... There are numerous foreigners that are flying to India and desperate ... Kerala or the beautiful beaches// of Goa but to rid themselves ... a Canadian, Amir a Bangladesh-born American and Hardeep a Sikh from ... hub of laparoscopic surgeries is Kolkata as shows the flooding of ...
... its last lap of seeking enrollment from drug companies, and results ... three major insurance players. ,United Health Group seems to be ... and a financial agreement with them to support the company. AARP ... ,80 companies have been in the fray with more ...
... known for its severe dearth of general practitioners, further substantiated ... the throes of a severe GP crisis. ,The research ... current trend of Doctors, gravitating to specialist sectors, which if ... sector lean and totally understaffed. ,Dr Catherine Joyce ...
Cached Medicine News:Health News:Old Men Do Not Benefit From Screening of Prostate Cancer 2Health News:India is the "IT" destination for obesity cure: med tourism 2
(Date:5/22/2015)... Taskforce representing Canada,s living victims of ... the Minister and Health Canada have put into this program ... of the thalidomide survivors, and more than 70% of them ... annual adjustments for inflation. Certain of the thalidomide ... on the severity of their disability, tax free, with inflation ...
(Date:5/22/2015)... HILL, N.C. , May 22, 2015 /PRNewswire/ ... critical to pharmaceutical brand recognition and success. ... LLC conducted a study to provide pharmaceutical and ... of investment (FTEs and budget) that are being ... Pharmaceutical and biotech marketing managers can utilize this ...
(Date:5/22/2015)... , May 22, 2015 The leading ... $13 billion global cardiac rhythm management device market ... found that Medtronic, St. Jude Medical, Boston Scientific ... of this market segment. The healthcare market research ... , uses 2015 as a base year, providing ...
Breaking Medicine Technology:Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4
... /PRNewswire-Asia/ -- Recently, Wang Qiao, the eight-year program student ... tutored under Yan Lynan, went to San Francisco to ... meeting with the director of his department, Mr. Li ... The theme of the meeting is "The Pros ...
...  Marken announced today that it has opened its first ... service operations and offer local service to its customers ... operates in the country through its partners, managing thousands ... country.  This new office has been created recognizing that ...
Cached Medicine Technology:Student of Liver And Vascular Surgery of West China Hospital of Sichuan University Addresses The 18th ILTS Annual Meeting in the United States 2Marken Opens Branch Office In Seoul, South Korea 2
... The assay is a direct competitive ... in human serum or plasma. A specific ... it available for antibody binding. Estradiol then ... to fluorescein isothiocyanate (FITC) and alkaline phosphatase ...
... the most potent, naturally secreted estrogen and ... ovary [1]. In the ovary, estradiol is ... a less potent estrogen derived from androstenedione. ... body tissues. In men, small amounts of ...
... troponin I (cTnI) has been useful in ... Emergency Departments (ED) with chest pain. 18-20 ... when blood levels of sensitive and specific ... isoenzyme of creatine kinase (CK-MB), and myoglobin, ...
The second-generation Dade Behring Acute Care Troponin I (cTnI) method is the first FDA cleared high sensitivity cTnI assay with the low-end precision necessary to meet the ESC/ACC guidelines (CV <10...
Medicine Products: