Navigation Links
NIH grants to Children's Hospital will advance novel stem cell treatments for blood disorders
Date:2/16/2010

In addition to boosting the supply of platelets to carry out their usual biological roles, the researchers also seek to customize them as drug delivery vehicles. In mouse studies, for instance, Poncz's team previously treated the bleeding disorder hemophilia by loading platelets with the clotting factor that is deficient in that disease. "In addition to investigating platelets for treating hemophilia in people, we will investigate their potential role in delivering other bioactive proteins to sites of vascular injury," said Poncz. "For instance, platelets might deliver an enzyme called urokinase to selectively disintegrate blood clots."

Second grant will investigate induced pluripotent stem cells A separate grant from the NHLBI also supports stem cell research, but focuses on a more recently discovered type of cell. This two-year, $997,000 grant was awarded to hematologist Mitchell Weiss, M.D., Ph.D. The Grand Opportunity (GO) Grant, funded by the American Recovery and Reinvestment Act, is part of an NHLBI program to support novel research designed to quickly advance an area of biomedicine in significant ways.

Scientists demonstrated in 2007 that they could reprogram human somatic cells (the vast majority of cells that are not sperm or egg cells) into a pluripotent statethe capacity to develop into other types of human cells. In this project, Weiss and colleagues will manipulate induced pluripotent stem cells (iPSCs) into becoming hematopoietic, or blood-forming, cells.

"These cells represent a potentially remarkable tool for custom-fitting new tissue to an individual patient," said Weiss. "Because they originate from an individual patient's cells, they will not be rejected as foreign by the patient's immune system." But much work remains to be done in fully characterizing how iPSCs develop, and in understanding how they may differ from both hESCs and from typical blood cells.

Weiss will also investigate iPSCs as a powerful new m
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. U.S. Labor Department Awards $10.1 Million for Safety and Health Training Grants
2. Sunesis Pharmaceuticals Reports New Option Grants Under NASDAQ Marketplace Rule 4350
3. American Cancer Society awards research grants to 109 investigators at 77 institutions nationwide
4. USAID Announces First Malaria Communities Program Grants
5. The Highmark Foundation Awards $580,000 in Highmark Healthy High 5 Grants to Four Non-Profit Organizations
6. KV Pharmaceutical Company Reports Results of Special Independent Committee Review of Stock Option Grants
7. FDA Grants Clearance to Langford IC Systems, Inc.
8. Dienst Custom Homes Grants Over 40 Wishes in Three Years
9. United Animal Nations Offers Financial Assistance Grants of up to $500 to Help Southern California Fire Victims Obtain Vet Care, Temporary Boarding for Pets
10. PA Health Department Awards Community Primary Care Challenge Grants
11. FDA Grants Kiadis Pharma Lead Product ATIR Orphan Drug Designation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014 The holidays are here, and ... season. Many may be thinking about how to enjoy these ... few weeks. Health Republic Insurance of New York has compiled ... Chernus, to provide some smart ideas to enjoy the holiday ... 1)    Avoid arriving at a holiday gathering over-hungry , Have a ...
(Date:12/22/2014)... Shanghai, China (PRWEB) December 22, 2014 ... for MabThera (rituximab) for the treatment of non-Hodgkin’s lymphoma ... Health , a leading global healthcare consulting firm. MabThera ... B-cell lymphoma (DLBCL), the most common form of NHL. ... Market Access and Barriers,” the incidence of NHL in ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Only weeks ... southern and mid-western cities to have a battery manufacturer ... TalkLocal ( http://www.talklocal.com ) is launching in Henderson ... economy. , “A strong manufacturing sector is going ... founder Gurpreet Singh explained, “and TalkLocal works with small ...
(Date:12/22/2014)... Pasadena sleep apnea dentist, Dr. Marine ... drivers are 15 times more likely to cause deadly ... experts believe that sleep-deprived drivers may be just as ... of Americans may be sleep-deprived without even knowing it. ... 18 million Americans have sleep apnea, but as many ...
(Date:12/22/2014)... Luxury Linen purveyor Peacock Alley ... to provide logistics and support for one of Dallas’ ... a long history of giving back to the community in ... year's Toy Drive were Whataburger® and 99.5 The Wolf. , ... holidays. Providing gifts to children who would otherwise not receive ...
Breaking Medicine News(10 mins):Health News:Health Republic Insurance of New York Offers Five Simple Tips to Eat Healthy During the Holidays 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2
... Rao, an American scientist of Indian origin has been ... a new system which makes use of data for ... is the Senior Director of Engineering Research Development at ... ,Rao is reported to have contributed towards ...
... drinkers go in for wholesome and healthy food, beer drinkers ... also seen among// wine drinkers when compared to beer ... in Copenhagen have found that beer drinkers buy unhealthy food ... prefer wine, according to BBC News. ,Studying ...
... Jefferson and colleagues from Cochrane Collaboration (International private organization ... trials) reviewed data from over 50 clinical trials involving ... researchers found that the old drugs which were used ... some drugs like amantadine and rimantidine which were used ...
... employ people with Asperger's Syndrome, who suffer from difficulties ... total of 50,000 people who suffer from this disorder, ... //People who suffer from the Asperger's Syndrome have difficulty ... though the intelligence of those who suffer from this ...
... Researchers from McMaster University has reported in the Journal ... found that the scientists screened 480 strains of Streptomyces ... all the strains were multi-drug resistance //as they were ... antibiotics. ,The researchers were astonished by ...
... transmission case is due today in Harbin court today. The ... blood collected from an infected couple who sold their blood ... Northeast China. // It was found that 15 people were ... and the other four got infection indirectly from the infected, ...
Cached Medicine News:
(Date:12/19/2014)... You,re visiting the dentist for what you ... or she says you need a root canal. Though ... have several questions and feel apprehensive about your upcoming ... nothing to worry about. The Pennsylvania Dental Association (PDA) ... anxiety the public may have surrounding this common procedure ...
(Date:12/19/2014)... , Dec. 19, 2014 In ... research and marketing communication tools are essential for ... competitive – consequently consumers, desires, preferences, and unmet ... environment, market research groups across all industries are ... communication tools. However, the adoption of new market ...
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/942kh3/micro_market ) ... Market Monitor: North American Dermatology Diagnostic Devices Market" ... http://photos.prnewswire.com/prnh/20130307/600769 Cosmetic surgeries ... resulted in fueling the overall demand of the ... these dermatology devices is to assist in identifying ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3
... , , NEW YORK, ... ), a medical technology company testing its proprietary treatment method for ... and Safety Monitoring Board ("DSMB") reviewed clinical data on 77 patients ... that the trial continue to enroll patients with the goal of ...
... , LISBON, Portugal, September 11 ... Confirms Superiority of the New Intranasal Treatment,for Breakthrough Cancer Pain ... today further demonstrate the efficacy of Instanyl in,management of breakthrough ... of the European Federation of Chapters of the International,Association for ...
Cached Medicine Technology:Data Safety Monitoring Board Unanimously Recommends Continuation of Delcath's Phase III Clinical Trial 2Data Safety Monitoring Board Unanimously Recommends Continuation of Delcath's Phase III Clinical Trial 3Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 2Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 3Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 4
... potent, naturally secreted estrogen and is the ... In the ovary, estradiol is produced from ... potent estrogen derived from androstenedione. Estrone and ... In men, small amounts of estradiol are ...
... ADV is a Microparticle ... the quantitative determination of ... human serum or plasma ... Troponin-I values are used ...
... most potent, naturally secreted estrogen and is ... [1]. In the ovary, estradiol is produced ... less potent estrogen derived from androstenedione. Estrone ... tissues. In men, small amounts of estradiol ...
The second-generation Dade Behring Acute Care Troponin I (cTnI) method is the first FDA cleared high sensitivity cTnI assay with the low-end precision necessary to meet the ESC/ACC guidelines (CV <10...
Medicine Products: