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NIH grant to Emory and pediatric partners aims to improve kidney transplants for children
Date:3/11/2008

transplant patients' T cell repertoires evolve as they get older.

The team plans to develop ways to "fingerprint" the pediatric patients' immune systems with information on which genes are turned on and off in their white blood cells. With that information as a diagnostic tool, therapy could be tailored to an individual child at a given point in time, Dr. Kirk says.

"The good news is that outcomes in kidney transplantation have become much more successful in the last couple of decades," says Barry Warshaw, MD, chief of pediatric nephrology at Children's Healthcare of Atlanta and associate professor of pediatrics at Emory. "The bad news is that kidney transplants still dont last a lifetime."

Dr. Warshaw says one of the key aims of the clinical studies will be to develop a simple blood or urine test to inform doctors whether kidney rejection is "revving up," possibly avoiding painful biopsies.

"We're very excited about this grant and expect that it will one day be seen as a landmark in pediatric renal transplantation," he says.


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Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

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