Navigation Links
NIH grant to Emory and pediatric partners aims to improve kidney transplants for children
Date:3/11/2008

Emory University School of Medicine and Children's Healthcare of Atlanta are teaming up with two university hospitals in California to find new ways to make kidney transplants more tolerable for children.

Emory and Children's will partner with UCLA's Mattel Childrens Hospital in Los Angeles and Lucile Packard Children's Hospital at Stanford in Palo Alto for a study of kidney transplants in children.

The National Institutes of Health has awarded the partner institutions a five-year grant totaling approximately $6 million for Clinical Trials in Organ Transplantation in Children (CTOT-C).

In the last decade, doctors have been able to refine the regimens of drugs given to transplant patients. Successful transplantation depends on immunosuppressant drugs to prevent tissue rejection, but the drugs bring multiple side effects such as kidney disease and an increased risk of cardiovascular disease.

"Most anti-rejection drugs were developed in adults and are adapted for children by simply adjusting for weight," says Allan Kirk, MD, PhD, scientific director of the Emory Transplant Center and the study's leader. "But the immune system doesnt grow in parallel with a child's weight. The result is that children are often over-immunosuppressed."

Coordinating work among the three university hospitals will allow the study to encompass a group of patients that spans various demographic groups and national origins, says Dr. Kirk, who is a professor of surgery and pediatrics at Emory School of Medicine, a Georgia Research Alliance Eminent Scholar, and an attending surgeon at Children's Healthcare of Atlanta.

As children mature and are gradually exposed to various environmental stresses, such as viral infections, the set of T cells (white blood cells) they have in their bodies that are able to respond to infections or other outside agents changes.

Part of the CTOT-C program will catalog and define how pediatric kidney transplant patients' T cell repertoires evolve as they get older.

The team plans to develop ways to "fingerprint" the pediatric patients' immune systems with information on which genes are turned on and off in their white blood cells. With that information as a diagnostic tool, therapy could be tailored to an individual child at a given point in time, Dr. Kirk says.

"The good news is that outcomes in kidney transplantation have become much more successful in the last couple of decades," says Barry Warshaw, MD, chief of pediatric nephrology at Children's Healthcare of Atlanta and associate professor of pediatrics at Emory. "The bad news is that kidney transplants still dont last a lifetime."

Dr. Warshaw says one of the key aims of the clinical studies will be to develop a simple blood or urine test to inform doctors whether kidney rejection is "revving up," possibly avoiding painful biopsies.

"We're very excited about this grant and expect that it will one day be seen as a landmark in pediatric renal transplantation," he says.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Related medicine news :

1. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
2. Mass. General Hospital receives Gates Foundation grant to expand HIV controllers study
3. Doug Flutie, Jr. Foundation Grants NAA $10,000 for Burbacher/Charleston Study
4. NYU College of Nursing researcher awarded $4.1M grant to study nurses work decisions
5. Highmark Inc. Supports Employee Volunteerism Efforts with $5,500 in Community Grants
6. Alzheimers Foundation of America Awards Grants to Local Groups Nationwide
7. AMA Foundation Announces Seed Grant Research Recipients
8. FDA Grants Over-The-Counter Clearance to GentleWaves(R) for the First Home Use Light-Based Device to Treat Wrinkles
9. EPA Funds Grants for Lead Poisoning Prevention Projects in Two Wisconsin Communities
10. EPA Funds Grants for Four Lead Poisoning Prevention Projects in Michigan Communities
11. EPA Funds Grants for Lead Poisoning Prevention Projects in Two Ohio Communities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... Dr. Sadati’s recent ... cosmetic procedures. Along with performing procedures, the magazine also highlights that Dr. Sadati ... procedures. One of the most common procedures he performs is his natural facelift. ...
(Date:2/11/2016)... Chicago, IL (PRWEB) , ... February 11, 2016 ... ... dedicated to the healthcare industry, ranked among the top five firms in the ... Services and HIT Implementation Support and Staffing. KLAS is a research and insights ...
(Date:2/11/2016)... ... February 11, 2016 , ... Atlantic Information Services, ... Benefit Model: A Case Study for Plans and Purchasers.” Executives from Intel Corp. ... with Intel on value-based health benefits program Connected Care, will discuss the challenges ...
(Date:2/11/2016)... ... February 11, 2016 , ... Life is known for throwing curves. It’s ... older, who gather once a year to play softball to raise money through ... the more than 50 players who competed in this year’s softball tournament share a ...
(Date:2/11/2016)... Laredo, TX (PRWEB) , ... February 11, 2016 ... ... and surrounding communities with their ongoing community involvement program, introduces a new charity ... with hospitalized children, donations are now being accepted at https://donate.rmhc.org/ . , ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- Walgreens has committed to provide drug disposal kiosks ... D.C. as part of a program to combat ... advocacy organization As You Sow. Conrad MacKerron , ... on to unneeded drugs because they lack easily accessible collection ... --> Conrad MacKerron , Senior Vice President at As ...
(Date:2/11/2016)... 11, 2016   Health 2.0 , the premiere ... technologies, announced today " 10 Year Global Retrospective ", ... over the past ten years.   ... Health 2.0 has served as the preeminent thought-leader in ... thousands of technologies, companies, innovators, and patient-activists through an ...
(Date:2/11/2016)... , Feb. 11, 2016  NOIT™ Research LLC, a ... "Gift of Change" campaign to assist needy families in ... such unit sold between February 10, 2016 and March ... a needy family. The NOIT is an auditory stimulus ... individuals develop language skills. Beth Shier ...
Breaking Medicine Technology: