Navigation Links
NIH grant to Emory and pediatric partners aims to improve kidney transplants for children
Date:3/11/2008

Emory University School of Medicine and Children's Healthcare of Atlanta are teaming up with two university hospitals in California to find new ways to make kidney transplants more tolerable for children.

Emory and Children's will partner with UCLA's Mattel Childrens Hospital in Los Angeles and Lucile Packard Children's Hospital at Stanford in Palo Alto for a study of kidney transplants in children.

The National Institutes of Health has awarded the partner institutions a five-year grant totaling approximately $6 million for Clinical Trials in Organ Transplantation in Children (CTOT-C).

In the last decade, doctors have been able to refine the regimens of drugs given to transplant patients. Successful transplantation depends on immunosuppressant drugs to prevent tissue rejection, but the drugs bring multiple side effects such as kidney disease and an increased risk of cardiovascular disease.

"Most anti-rejection drugs were developed in adults and are adapted for children by simply adjusting for weight," says Allan Kirk, MD, PhD, scientific director of the Emory Transplant Center and the study's leader. "But the immune system doesnt grow in parallel with a child's weight. The result is that children are often over-immunosuppressed."

Coordinating work among the three university hospitals will allow the study to encompass a group of patients that spans various demographic groups and national origins, says Dr. Kirk, who is a professor of surgery and pediatrics at Emory School of Medicine, a Georgia Research Alliance Eminent Scholar, and an attending surgeon at Children's Healthcare of Atlanta.

As children mature and are gradually exposed to various environmental stresses, such as viral infections, the set of T cells (white blood cells) they have in their bodies that are able to respond to infections or other outside agents changes.

Part of the CTOT-C program will catalog and define how pediatric kidney transplant patients' T cell repertoires evolve as they get older.

The team plans to develop ways to "fingerprint" the pediatric patients' immune systems with information on which genes are turned on and off in their white blood cells. With that information as a diagnostic tool, therapy could be tailored to an individual child at a given point in time, Dr. Kirk says.

"The good news is that outcomes in kidney transplantation have become much more successful in the last couple of decades," says Barry Warshaw, MD, chief of pediatric nephrology at Children's Healthcare of Atlanta and associate professor of pediatrics at Emory. "The bad news is that kidney transplants still dont last a lifetime."

Dr. Warshaw says one of the key aims of the clinical studies will be to develop a simple blood or urine test to inform doctors whether kidney rejection is "revving up," possibly avoiding painful biopsies.

"We're very excited about this grant and expect that it will one day be seen as a landmark in pediatric renal transplantation," he says.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Related medicine news :

1. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
2. Mass. General Hospital receives Gates Foundation grant to expand HIV controllers study
3. Doug Flutie, Jr. Foundation Grants NAA $10,000 for Burbacher/Charleston Study
4. NYU College of Nursing researcher awarded $4.1M grant to study nurses work decisions
5. Highmark Inc. Supports Employee Volunteerism Efforts with $5,500 in Community Grants
6. Alzheimers Foundation of America Awards Grants to Local Groups Nationwide
7. AMA Foundation Announces Seed Grant Research Recipients
8. FDA Grants Over-The-Counter Clearance to GentleWaves(R) for the First Home Use Light-Based Device to Treat Wrinkles
9. EPA Funds Grants for Lead Poisoning Prevention Projects in Two Wisconsin Communities
10. EPA Funds Grants for Four Lead Poisoning Prevention Projects in Michigan Communities
11. EPA Funds Grants for Lead Poisoning Prevention Projects in Two Ohio Communities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... 30, 2017 , ... The Aresty Institute of Executive Education ... to address the increasingly complex educational needs of today's global executives. Corporate ... corporate finance and will increase their ability to confidently take action in ways ...
(Date:3/30/2017)... Durham, NC (PRWEB) , ... March 30, 2017 ... ... professionals, will host the live audio conference “ Preventing Hospital Readmissions Through Discharge ... April 12, 2017 at 1:00 pm ET. This conference discusses strategies to prevent ...
(Date:3/29/2017)... ... March 29, 2017 , ... In the United States alone, up ... year develop other types of metastatic brain tumors(3). Though most meningiomas are benign, metastatic ... focus on finding more effective treatment options, the San Diego Gamma Knife Center ...
(Date:3/29/2017)... , ... March 30, 2017 , ... CHARM CITY RUN ... Run has announced that Mercy Medical Center will serve as the official title sponsor ... region. On Sunday, June 25, 2017, thousands of women will walk or run the ...
(Date:3/29/2017)... ... March 29, 2017 , ... Wells Pharmacy Network, a proud ... the upcoming World Congress, in Hollywood Florida April 6-8, 2017. , Ben David, ... visionary leader in the training of physicians, scientists, and members of the public ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017  The leader in accelerated orthodontics, OrthoAccel ® ... Daher , Manal Ibrahim , Kenji Ojima ... be the featured microlecture presenters at the AcceleDent ® ... Orthodontists (AAO) Annual Session, April 21-25, 2017. Orthodontists and ... daily at 11:20 a.m. On the opening morning of ...
(Date:3/29/2017)... New York , March 29, 2017 /PRNewswire/ ... recently published a report, which provides an exhaustive ... to the study, nearly 242 companies are functional ... fragmented and competitive. With the leading companies, such ... Purdue Pharma LP, focusing aggressively on various marketing ...
(Date:3/29/2017)... , March 29, 2017 Varian Medical Systems ... report results for the second quarter of fiscal year 2017 ... 2017.  The news release will be followed by a teleconference ... news release and a link to the conference call webcast ... .  To access the teleconference call and replay: ...
Breaking Medicine Technology: