Navigation Links
NIH funds development of new broad-spectrum therapeutics
Date:10/13/2011

Four companies are to develop broad-spectrum therapeuticsantibiotics, antivirals and an antitoxinto prevent or treat diseases caused by multiple types of bacteria or viruses, under contracts awarded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Total funding for the four contracts could reach $150 million over a maximum five-year period.

The contracts are designed to support essential research and development activities to enable promising investigational therapies to move toward early-phase clinical studies and, if successful in clinical studies, on to eventual licensure. The ultimate goal is to develop products that the U.S. government can stockpile to protect the public in the event of a bioterror attack or public health crisis.

In line with NIAID's strategic plan for biodefense and emerging infectious diseases research, these contracts move beyond the paradigm of drug development that is sometimes called "one-bug, one-drug." (http://www.niaid.nih.gov/topics/BiodefenseRelated/Biodefense/Documents/biosp2007.pdf)The contracts are to focus on candidate therapies that can be used against classes of pathogens rather than being agent-specific. Such broad-spectrum therapeutics would improve preparedness for all infectious threats, whether they occur naturally or are deliberately introduced.

The following companies are recipients of the new contracts:

CUBRC Inc., Buffalo, N.Y., in partnership with Tetraphase Pharmaceuticals, Watertown, Mass.Researchers will develop a fully synthetic tetracycline product, TP-271, to treat the bacterial disease tularemia, and respiratory infections such as community-acquired bacterial pneumonia. Both intravenous and oral formulations of the drug will be evaluated in preclinical studies for safety and efficacy, and several preliminary 1 clinical trials are planned. The compound will also be tested in nonclinical studies for activity against anthrax and plague. The initial award is for $5.7 million, with the potential for up to $35 million over five years.

Enanta Pharmaceuticals Inc., Watertown, Mass.Researchers will develop and evaluate a candidate from a novel class of next-generation broad-spectrum antibiotics known as bicyclolides. Bicyclolides are small-molecule anti-infectives. Enanta's bicyclolide has demonstrated potential for activity against anthrax, plague and tularemia in cell culture studies, as well as efficacy against anthrax and tularemia in mice. The compound will be evaluated for effectiveness against multiple bacteria that might be used as agents of bioterror, and several Phase 1 clinical trials are planned. Bicyclolides represent a promising new class of broad-spectrum antibiotics that have demonstrated activity against the two major groups of bacteria, known as gram-negative and gram-positive bacteria. These groups of bacteria are distinguished by the presence or absence of peptidoglycan, which is visible in lab specimens when the bacteria are stained using the Gram method. In general, the two types of bacteria are treated using different types of drugs.The initial award is for $14.3 million with the potential for a five-year total of up to $43 million.

Unither Virology LLC, Silver Spring, Md.Unither will develop and evaluate UV-4, an investigational antiviral drug with potential as a treatment for influenza and dengue fever and possible applications for viral hemorrhagic fever, smallpox and hepatitis. The drug is derived from a class of compounds known as iminosugars that includes drugs approved for other indications, such as diabetes and Gaucher's disease. UV-4, which may also reduce the potential for drug resistance, is expected to undergo toxicity studies, a preliminary safety study and a Phase 2 clinical trial for dengue fever. Unither has received an initial award of $10.5 million with the potential for up to $45 million over five years.

XOMA (US) LLC, Berkeley, Calif.The company will develop an intravenous antitoxin to treat human botulism poisoning. XOMA's monoclonal antibody product will target serotypes C and D of Clostridium botulinum neurotoxin and would also neutralize C/D and D/c mosaic/hybrid toxins. The development of human botulinum monoclonal antibodies would replace existing horse-based antitoxin products that are difficult to make and pose safety concerns for humans. A preliminary clinical trial is planned for XOMA's anti-C/D toxin product. The company received $7 million in its initial NIAID award with the potential for up to $28 million in five years.


'/>"/>

Contact: Ann Mosher
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Federal Recovery Funds Allow Eries Shriners Hospital to Reduce Energy Costs, Invest Savings in Patient Care
2. Three Security Firms Create Consortium To Automate Meaningful Use Requirements And Qualify Clients For $Billions In Stimulus Funds
3. Study: Federal funds support health depts., but leadership is key
4. Legacy(SM) Case for Tobacco Funds to be Heard by Ohio Supreme Court
5. Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital
6. EVMS receives more than $1 million in federal funds to develop new ways to reverse type 1 diabetes
7. Major League Baseball Players Alumni Help Lazarex Cancer Foundation Raise Funds
8. Prize4Life Launches “Art, Life, Spring” Online Art Auction to Raise Funds for Lou Gehrig's Disease Research
9. Just Graduated College Seniors Ride for Loved Ones With Diabetes Cycling Cross Country to Raise Funds to Help Find a Cure
10. Only 5 percent of cancer research funds are spent on metastases, yet it kills 90 percent of all cancer patients
11. Amazing Grace Charity Golf Tournament to Raise Awareness, Funds for Neuroblastoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... Aviv, Israel (PRWEB) , ... April 26, 2017 , ... ... today announced a new partnership with Med-e-Mass , the largest Electronic Medical Records ... enable Med-e-Mass to link care plan incentives to a patient’s remote health progress, empowering ...
(Date:4/26/2017)... ... April 26, 2017 , ... Infertility may be a result ... has helped many women become pregnant upon treating their diagnosis. , ... outpatient evaluations. We can provide the necessary information to diagnose and treat ...
(Date:4/26/2017)... ... April 26, 2017 , ... Want to ... website ( CRISPRCas.pioneer.com ) that demonstrates how this advanced plant breeding technology is ... better food, with fewer resources. It highlights the business’ principles, research and collaboration ...
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... ... human performance, is proud to announce that it has received 510(k) clearance from ... the MyoCycle Home and the MyoCycle Pro. , Both devices are stationary cycling ...
(Date:4/25/2017)... ... April 25, 2017 , ... ProRehab Physical ... be the preferred physical therapy provider for Derby City CrossFit, effective immediately. , ... CrossFit as quickly and effectively as possible, ProRehab’s sports physical therapists will work ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017 Research and Markets has ... Manufacturing Services Market Analysis By Service (Manufacturing, Research), By Country, ... - 2025" report to their offering. ... The Latin American pharmaceutical contract manufacturing ... 2025 Low drug registration cost in Latin American ...
(Date:4/19/2017)... 2017 Global Surgical Drainage Device Market: Overview ... to remove excess liquid and air. The fluid to ... or lymph. Surgical drains are used in a wide ... surgery, cardiovascular surgery, neurosurgery, plastic surgery etc. Common use ... accumulation of fluid e.g. blood or pus. Surgical drains ...
(Date:4/19/2017)... , April 19, 2017 ... an immune response in pets such as canine, ... are of various types such as Attenuated Live ... Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated live ... virus or bacteria, which have been weakend under ...
Breaking Medicine Technology: