Navigation Links
NIH funds UT Dallas study on cause of Huntington's disease
Date:3/26/2013

Dr. Santosh D'Mello, professor of molecular and cell biology at the University of Texas at Dallas, has received a federal grant for research that may shed light on why and how specific brain cells are affected by Huntington's disease, a devastating, degenerative brain disorder.

The grant from the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, provides $1.67 million over 5 years.

"Results from our studies could provide valuable insight into why specific brain cells degenerate in Huntington's disease," said D'Mello, who holds appointments in the School of Natural Sciences and Mathematics and the School of Behavioral and Brain Sciences. "I'm pleased with this new grant, particularly given the current funding environment. We're eager to get started on this research."

Huntington's disease is caused by a genetic mutation that is passed down through families. According to the Huntington's Disease Society of America, more than 250,000 Americans have the disease or are at risk of inheriting the disease from an affected parent. The disorder causes parts of the brain to waste away, leading to progressively worsening symptoms ranging from behavioral changes to motor skill impairment to dementia. There is no cure or treatment that can alter the course of the disease.

D'Mello's research, which the NIH has supported for several years, is focused in general on investigating the biological mechanisms underlying neurodegenerative disorders, including Huntington's disease, Alzheimer's, Parkinson's and amyotrophic lateral sclerosis. His recent research results suggest that a key player in promoting neurodegeneration is a protein called histone deacetylase-3 (HDAC3). In preclinical studies, D'Mello's laboratory and other researchers have found that high levels of this protein are toxic to brain cells.

The new grant will allow D'Mello and his research team to investigate possible connections between HDAC3 and Huntington's disease. The genetic mutation responsible for the disorder affects a protein called huntingtin, resulting in a form of the protein that does not function properly. D'Mello will test the hypothesis that the mutant form of huntingtin inherited by patients with Huntington's disease activates the neurotoxic effects of HDAC3 that lead to brain-cell loss.

"Understanding these underlying mechanisms is an important step toward developing new strategies to treat neurodegenerative disorders," D'Mello said.

This is the third NIH grant D'Mello has received in the past year. Those grants have allowed his research group to pursue studies of proteins and genes that are linked to brain development, as well as the consequences of genetic mutations that result in neurodevelopmental disorders.

For example, the grants support D'Mello's work on the biological mechanisms of the proteins MeCP2 and FoxG1, mutations in which have been linked to a neurodevelopmental disorder called Rett syndrome that primarily affects girls.

In recently published research, D'Mello's laboratory found that elevated levels of the FoxG1 protein have a highly protective effect on cultured brain cells. Those findings are now being extended to mice, D'Mello said. He is developing mice that are genetically engineered to overproduce FoxG1 in the brain and will examine whether high levels of the protein can protect against brain degeneration. If that theory is borne out, he said, it could have implications for drug development and treatment strategies for neurodegenerative disorders.


'/>"/>

Contact: Amanda Siegfried
amanda.siegfried@utdallas.edu
972-883-4335
University of Texas at Dallas
Source:Eurekalert

Related medicine news :

1. EU funds research project on obesity and metabolic complications
2. Local Chiropractor Hosting Free Community Event and Giving an iPad Mini Away to Raise Funds for Nonprofit Children's Center at her Grand Opening
3. Healthentic Raises Funds to Support Seattle’s Homeless Population This Holiday Season
4. AdvisorsMD Donates Funds to Mision Vida Nueva
5. St. Michaels Dr. Sean B. Rourke receives federal funds for iHIV/AIDS research
6. DFG funds new Collaborative Research Center at the Mainz University Medical Center
7. CDC funds Wayne State University research to understand, prevent teen dating violence
8. Grant funds West Coast Metabolomics Center
9. ASHA grant funds cutting-edge AIDS research at Tel Aviv University
10. MTSS-mba Membership Benefits Administration Software for Private and Taft-Hartley Employee Benefit Funds Releases New Pension Modules
11. Dallas Dermatologist Christine Brown, M.D. Now Offers Breakthrough Technology to Freeze Away Fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... CT (PRWEB) , ... March 29, 2017 , ... HealthCareMandA.com ... —on Thursday, April 20, 2017, at 1:00 PM ET. A recording of the webinar ... the Interactive Webinar Series. , Home health and hospice companies are still popular targets ...
(Date:3/29/2017)... ... 2017 , ... Immunotherapy has emerged as one of the most promising options ... be the next revolution in our fight against this complex disease. One of the ... checkpoint inhibitors such as PD-1 and PD-L1 inhibitors. , While a few single analyte ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... Pittsburgh now have easier access to the robotic-assisted total-hip and partial-knee replacement ... (AHN). Orthopaedic surgeons at Forbes Hospital and Jefferson Hospital recently started performing ...
(Date:3/29/2017)... PA (PRWEB) , ... March 29, 2017 , ... The ... W’80, WG’81, and Julie Taffet Moelis, W’81, have made a $10 million gift to ... deferred admission opportunity that will provide a pathway to a Wharton MBA for highly-qualified ...
(Date:3/29/2017)... ... ... has helped over 1.5 million SharePoint users learn the content management system faster and ... for SharePoint was at the farm level. Enterprises using SharePoint Online in Office 365 ... recently released a modified version of the Help System, VisualSP for Site Collections, which ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... -- According to a new market research report "Medical Radiation ... Survey Meter, Solid-State), Products (Personal Dosimeters, OSL, Badges), Safety (Apron, Shields, Face ... market is expected to reach USD 1,215.4 Million by 2021 from USD ... 2021. Continue Reading ... ...
(Date:3/29/2017)... 29, 2017  The Pharmaceutical Care Management Association (PCMA) ... report on patient out-of-pocket spending: ... Services (CMS), the average amount spent out-of-pocket for drugs ... spending in 2016, down from 23% in 2006. ... not a coverage problem. Health plans don,t have unlimited ...
(Date:3/29/2017)... 29, 2017  Spiral Therapeutics, Inc. today announced ... Farma, S.L. for the worldwide exclusive rights to ... the field of otolaryngology for aggregate payments of ... The agreement provides Spiral with the option to ... product profile. Under the terms of the agreement, ...
Breaking Medicine Technology: