Navigation Links
NIH funds UT Dallas study on cause of Huntington's disease
Date:3/26/2013

Dr. Santosh D'Mello, professor of molecular and cell biology at the University of Texas at Dallas, has received a federal grant for research that may shed light on why and how specific brain cells are affected by Huntington's disease, a devastating, degenerative brain disorder.

The grant from the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, provides $1.67 million over 5 years.

"Results from our studies could provide valuable insight into why specific brain cells degenerate in Huntington's disease," said D'Mello, who holds appointments in the School of Natural Sciences and Mathematics and the School of Behavioral and Brain Sciences. "I'm pleased with this new grant, particularly given the current funding environment. We're eager to get started on this research."

Huntington's disease is caused by a genetic mutation that is passed down through families. According to the Huntington's Disease Society of America, more than 250,000 Americans have the disease or are at risk of inheriting the disease from an affected parent. The disorder causes parts of the brain to waste away, leading to progressively worsening symptoms ranging from behavioral changes to motor skill impairment to dementia. There is no cure or treatment that can alter the course of the disease.

D'Mello's research, which the NIH has supported for several years, is focused in general on investigating the biological mechanisms underlying neurodegenerative disorders, including Huntington's disease, Alzheimer's, Parkinson's and amyotrophic lateral sclerosis. His recent research results suggest that a key player in promoting neurodegeneration is a protein called histone deacetylase-3 (HDAC3). In preclinical studies, D'Mello's laboratory and other researchers have found that high levels of this protein are toxic to brain cells.

The new grant will allow D'Mello and his research team to investigate possible connections between HDAC3 and H
'/>"/>

Contact: Amanda Siegfried
amanda.siegfried@utdallas.edu
972-883-4335
University of Texas at Dallas
Source:Eurekalert

Page: 1 2

Related medicine news :

1. EU funds research project on obesity and metabolic complications
2. Local Chiropractor Hosting Free Community Event and Giving an iPad Mini Away to Raise Funds for Nonprofit Children's Center at her Grand Opening
3. Healthentic Raises Funds to Support Seattle’s Homeless Population This Holiday Season
4. AdvisorsMD Donates Funds to Mision Vida Nueva
5. St. Michaels Dr. Sean B. Rourke receives federal funds for iHIV/AIDS research
6. DFG funds new Collaborative Research Center at the Mainz University Medical Center
7. CDC funds Wayne State University research to understand, prevent teen dating violence
8. Grant funds West Coast Metabolomics Center
9. ASHA grant funds cutting-edge AIDS research at Tel Aviv University
10. MTSS-mba Membership Benefits Administration Software for Private and Taft-Hartley Employee Benefit Funds Releases New Pension Modules
11. Dallas Dermatologist Christine Brown, M.D. Now Offers Breakthrough Technology to Freeze Away Fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... 2014 OpenWorks, one of America’s leading ... 2014 Lincoln Guild Invitational. The John C. Lincoln Health ... the Phoenix-area Desert Mission community programs. Open Works was ... tournament was held at Camelback Golf Club in Scottsdale. ... efforts of Desert Mission — including a food bank, ...
(Date:11/18/2014)... (PRWEB) November 18, 2014 Sorrel Sky ... , showcasing a special selection of her beautiful, one-of-a-kind pieces. ... to stroll in to the gallery, Friday, December 5 from ... in Santa Fe. , Showers artistic creations began at her ... memories continue to inspire her designs. She studied at the ...
(Date:11/18/2014)... -- Hispanic women who,ve had at least five children are ... trouble than those who,ve had fewer children or none, a ... Shivani Aggarwal of Wake Forest School of Medicine analyzed data ... New York City and San Diego. About 12 percent of ... A type of heart trouble called ventricular diastolic dysfunction -- ...
(Date:11/18/2014)... HealthDay Reporter MONDAY, Nov. 17, ... infected with Ebola in his native country died Monday morning at ... Saturday at Nebraska Medical Center in Omaha. He was a general ... capital city of Freetown. Sierra Leone, Guinea and Liberia are ... Ebola outbreak that began last spring and is the worst in ...
(Date:11/17/2014)... 2014 Vernon Brewer, Founder and President of ... two weeks and saw firsthand the devastating holocaust that ISIS ... Iraq and Syria. , “‘Holocaust’ is not a term I ... or driven thousands of Christians and members of other faiths ... is desperate. As ISIS expands, they continue to kill ...
Breaking Medicine News(10 mins):Health News:OpenWorks Sponsors 2014 Lincoln Guild Invitational Golf Tournament Hosted by Scottsdale's Camelback Golf Club 2Health News:Elizabeth Showers Trunk Show & Personal Appearance Hosted by Sorrel Sky Gallery 2Health News:Certain Heart Dysfunction More Likely in Hispanic Women With Many Kids: Study 2Health News:Doctor With Ebola Dies at Nebraska Hospital 2Health News:President of WORLD HELP Travels to Iraq and Jordan; Finds Religious Holocaust Being Executed by ISIS 2Health News:President of WORLD HELP Travels to Iraq and Jordan; Finds Religious Holocaust Being Executed by ISIS 3
... ... Diet , many of their subscribers and readers demand for more alkaline and organic food…, ... (PRWEB) June 14, 2010 ... natural health and dieting products from all over the world. Since the launch of the ...
... faster deterioration of their other kidney if they have the ... finds. The results will be presented Sunday at The Endocrine ... more than 6,000 adults in the United States are living ... in function of their remaining kidney, depending on their age ...
... Neurosurgeons from across ... , ... On July 30 and 31, Buffalo will play host to the 4th Annual Brain Endoscopy ... American Association of Neurological Surgeons (AANS). The course is intended for neurosurgical residents, ...
... factors may not develop the condition, study suggests , ... number of obese people, those extra pounds do not ... report. , For those few without other risk factors ... obese doesn,t raise their risk of cardiovascular trouble. , ...
... , ... and dedication of emerging leader participants in VA Leadership Program ,Class of 2009, at VA ... a Lifeclinic Health Station to be used by its Veterans. , ... Burtonsville, MD (PRWEB) June 22, 2010 ...
... ... and uses it! ,Camera to data toggle application revolutionizes any Windows Mobile Device with Camera ... , ... Since the invention of the Kodak roll film camera in 1888, engineers, inspectors and professionals ...
Cached Medicine News:Health News:Official Alkaline Diet Site Launches Organic Food Store for Healthy Living And Natural Weight Loss 2Health News:Official Alkaline Diet Site Launches Organic Food Store for Healthy Living And Natural Weight Loss 3Health News:Metabolic syndrome in living kidney donors worsens function of remaining kidney 2Health News:International group of neurosurgeons to assemble in Buffalo 2Health News:International group of neurosurgeons to assemble in Buffalo 3Health News:Obesity Doesn't Always Guarantee Heart Disease 2Health News:Obesity Doesn't Always Guarantee Heart Disease 3Health News:Fresno Community Shows Appreciation to Veterans with Donation of Lifeclinic Health Station 2Health News:Mobile and Patented: DATA-TO-CAMERA TOGGLE on handheld device replaces old camera and clipboard approach everywhere! Beats IPAD to camera punch too..... 2
(Date:11/18/2014)... CRANBURY, N.J., Nov. 18, 2014  Palatin ... company developing targeted, receptor-specific peptide therapeutics for ... medical need and commercial potential, today announced ... 30, 2014.  Recent Highlights ... Dysfunction (FSD): , €7.5M ($9.8M) total upfront ...
(Date:11/18/2014)... 18, 2014 Tocagen Inc. today ... and progression free survival at six months for recurrent ... & Toca FC, compared to published benchmarks. HGG includes ... brain cancer. The data were delivered in an oral presentation ... Education Day of the Society for Neuro-Oncology (SNO) by ...
(Date:11/17/2014)... , Nov. 17, 2014 Asterias Biotherapeutics, ... the emerging field of regenerative medicine, today announced that ... Research and Development, will participate in a live Google ... Medicine (CIRM) discussing the latest progress in stem cell-based ... CIRM Google Hangout session is scheduled for Tuesday, November ...
Breaking Medicine Technology:Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2015 Results; Teleconference and Webcast to be held on November 18, 2014 2Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2015 Results; Teleconference and Webcast to be held on November 18, 2014 3Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2015 Results; Teleconference and Webcast to be held on November 18, 2014 4Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2015 Results; Teleconference and Webcast to be held on November 18, 2014 5Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2015 Results; Teleconference and Webcast to be held on November 18, 2014 6Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2015 Results; Teleconference and Webcast to be held on November 18, 2014 7Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 2Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 3Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 4Interim Data Show Increased Median Overall Survival of Recurrent Brain Cancer Patients Treated with Tocagen's Toca 511 & Toca FC, Compared to Published Benchmarks 5Asterias Biotherapeutics to Participate in Live Google Hangout Discussion of Stem Cell-Based Therapies for Spinal Cord Injury 2
... Multi-Center Study in Skin Graft Donor Site Patients ... Inc. (NYSE,Alternext: ULU) today announced that it has ... donor sites treated with Altrazeal(TM) Silver,compared with a ... be conducted at four clinical sites with 40,evaluable ...
... BATTLE CREEK, Mich., and EVANSTON, Ill., Oct. 20, ... Center of,Excellence for Simulation Research (CESR) of Western ... research partnership, using in,situ simulation to improve the ... (MI) to balloon angioplasty (D2B). Mentice Inc.,was selected ...
Cached Medicine Technology:ULURU Inc. Announces the Commencement of First Clinical Study Using Altrazeal(TM) Silver 2ULURU Inc. Announces the Commencement of First Clinical Study Using Altrazeal(TM) Silver 3American College of Cardiology and Center of Excellence for Simulation Research of Western Michigan University (CESR) Partner for in situ Simulation to Improve Team Communication and Door-to-Balloon (D2B) Time 2American College of Cardiology and Center of Excellence for Simulation Research of Western Michigan University (CESR) Partner for in situ Simulation to Improve Team Communication and Door-to-Balloon (D2B) Time 3American College of Cardiology and Center of Excellence for Simulation Research of Western Michigan University (CESR) Partner for in situ Simulation to Improve Team Communication and Door-to-Balloon (D2B) Time 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: