Navigation Links
NIH-funded study uses new technology to peek deep into the brain
Date:1/18/2011

Changes within deep regions of the brain can now be visualized at the cellular level, based on research on mice, which was funded by the National Institutes of Health. Published Sunday in Nature Medicine, the study used a groundbreaking technique to explore cellular-level changes over a period of weeks within deep brain regions, providing a level of detail not possible with previously available methods. The study was supported by the National Institute on Drug Abuse (NIDA), the National Cancer Institute, and the National Institute of Neurological Disorders and Stroke.

Researchers at Stanford University used time-lapse fluorescence microendoscopy, a technique that uses miniature probes to directly visualize specific cells over a period of time, to explore structural changes that occur in neurons as a result of tumor formation and increased stimulation in the mouse brain. This could lead to greater information on how the brain adapts to changing situations, including repeated drug exposure.

"Continued drug use leads to changes in neuronal circuits that are evident well after a person stops taking an addictive substance," said Dr. Nora D. Volkow, director of NIDA. "This study demonstrates an innovative technique that allows for a glimpse of these cellular changes within the brain regions implicated in drug reward, providing an important tool in our understanding and treatment of addiction."

Investigators focused on two brain regions within the study, the hippocampus and striatum. The striatum, a brain region important for motor function and habit formation, is also a major target for abused drugs. Some researchers believe that a shift in activity within the striatum is at least partly responsible for the progression from voluntary drug-taking to addiction. This new technique could allow a better understanding of how these processes occur at the cellular level, leading to insights into mechanisms underlying addictive behaviors.

"The results should now allow neuroscientists to track longitudinally in the living brain the effects of drugs of abuse at the levels of neural circuitry, the individual neuron, and neuronal dendrites," said Dr. Mark Schnitzer, corresponding author for the article. "For example, our imaging methods work well in the dorsal striatum, which we have followed with microscopic resolution over weeks in the live brain. This should permit researchers interested in the reward system to address a range of issues that were previously out of reach."


'/>"/>

Contact: NIDA Press Office
media@nida.nih.gov
301-443-6245
NIH/National Institute on Drug Abuse
Source:Eurekalert

Related medicine news :

1. NIH-funded scientists find 2009 H1N1 pandemic influenza vaccine protects mice from 1918 flu virus
2. University of Mississippi Medical Center to lead in nationwide NIH-funded Alzheimers study
3. NIH-funded study finds early HAART during TB treatment boosts survival rate in co-infected people
4. In NIH-funded study, researchers uncover step in brain events leading up to addiction
5. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
6. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
7. TV drama can be more persuasive than news program, study finds
8. Study carried out into biological risks of eating reptiles
9. Neuroimaging study may pave way for effective Alzheimers treatments
10. Study finds racial gaps continue in heart disease awareness
11. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... Sun Health registered ... the organization’s successful Care Transitions program at the 9th Annual Orthopedic ... “Minimizing Costs in the Post-Acute Environment Through Effective Transitions of Care.” , Major ...
(Date:5/5/2016)... Diego, CA (PRWEB) , ... May 05, 2016 , ... ... travel nursing firm, is encouraging people all over the United States to thank a ... May 12, Aya Healthcare will donate $5 to the American Red Cross of San ...
(Date:5/5/2016)... Ohio (PRWEB) , ... May 05, 2016 , ... United ... Cycle. , Clark brings more than 15 years of experience within the healthcare ... from a successful career as the Director of Patient Financial Services at Spectrum Health. ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... for iOS and Android devices. VisualDx is the first point of care ... support across general medicine. The system speeds diagnosis, therapy decisions and patient ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... With May flowers, summer is just around ... it means a welcome respite from school and the ability to play all day and ... for their children or watch the little tykes themselves. Summer also means trips to the ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 According to ... Growth and Demand Forecast to 2022 - Industry Insights by ... Diagnostic Center and Others)" by P&S Market Research, the global ... in 2015, and it is expected to grow at a ... high slice type segment is expected to witness the faster ...
(Date:5/4/2016)... D.C. , May 4, 2016 ... member companies concluded a series of free workshops ... in global requirements for Good Distribution ... of quality assurance which ensures that products are consistently stored, ... the marketing authorization (MA) or product specification. Only a ...
(Date:5/4/2016)... DUBLIN , May 4, 2016 /PRNewswire/ ... the addition of the  "Global Multiple Myeloma ...  report to their offering.       ... Multiple Myeloma Market and Competitive Landscape Highlights ... pipeline products, Multiple Myeloma epidemiology, Multiple Myeloma ...
Breaking Medicine Technology: