Navigation Links
NIH-funded scientists reveal structure of HIV protein key to cell entry

Using protein engineering and two different cutting-edge structural biology imaging techniques, researchers have developed a detailed picture of the protein largely responsible for enabling HIV to enter human immune cells and cause infection. An in-depth understanding of the atomic structure of the HIV envelope trimeror Env, the three-component protein found on HIV's surfaceis critical to better understanding how HIV gains entry into cells and for creating potential HIV vaccines.

Atomic-resolution imaging of the Env protein has previously been elusive because of the protein's complex, delicate structure. To capture the image, a team of scientists at The Scripps Research Institute and Weill Medical College of Cornell University engineered a more stable version of the protein. Then, in separate studies, using first cryo-electron microscopy and then X-ray crystallography, the researchers were able to reveal the structure of the Env trimer, how it assembles and how it interacts with broadly neutralizing antibodies that target HIV.

Their research, described in two papers published online today in Science Express, received major support from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.


Contact: NIAID Office of Communications
NIH/National Institute of Allergy and Infectious Diseases

Page: 1

Related medicine news :

1. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
2. NIH-funded analysis estimates effective PrEP dosing
3. NIH-funded trial launched to assess experimental TB drug
4. Better stroke care, everywhere: NIH-funded study boosts local hospitals clotbuster use
5. NIH-funded researchers begin trial of Shigella vaccine candidates
6. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
7. Scientists solving the mystery of human consciousness
8. Scientists uncover multiple faces of deadly breast cancer
9. Scientists identify major source of cells defense against oxidative stress
10. Scientists tailor cell surface targeting system to hit organelle ZIP codes
11. Scientists rewrite rulebook on breast cancer in landmark global study
Post Your Comments:
Related Image:
NIH-funded scientists reveal structure of HIV protein key to cell entry
(Date:11/24/2015)... ... November 24, 2015 , ... ... States to support their local poison centers through donations on Tuesday, Dec. 1, ... calls it “a day that inspires people to collaborate in improving their local ...
(Date:11/24/2015)... R.I. (PRWEB) , ... November 24, 2015 , ... With ... Amica Insurance is sharing safety tips to help protect your family and vehicle. , ... crashes around the 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... designated an Aetna Institute of Quality® Bariatric Surgery Facility for treating individuals living ... cost of health care services available to its members to help them make ...
(Date:11/24/2015)... ... November 24, 2015 , ... Sir Grout of Baltimore is ... certification. The award recognizes good companies for excellence in service and a commitment ... and hard surface restoration company earned this recognition after a thorough review by ...
(Date:11/24/2015)... York, N.Y. (PRWEB) , ... November 24, 2015 , ... ... Giving Tuesday, the global movement driven by social media and the generosity of people ... Speaks, then encourage their social media networks to give – and share the personal ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 2015 F1000Workspace - a research ... it was launched just six months ago. --> ... platform for scientists - since it was launched just six ... loaded on to F1000Workspace - a research collaboration, ... was launched just six months ago. --> ...
(Date:11/24/2015)... 1, a free mobile-first network that enables healthcare professionals ... new completely redesigned web version that includes uploading. The ... primarily on a desktop, to upload images directly from ... base, Figure 1 is hosting an event during the ... (RSNA) Annual Meeting. Joshua Landy , ...
(Date:11/24/2015)... -- iRhythm Technologies, Inc. , a leading digital health care ... will participate in the 27th Annual Piper Jaffray Healthcare Conference at ... . Kevin King , Chief Executive Officer of ... 8:50am ET. --> --> ... . --> iRhythm is a privately held ...
Breaking Medicine Technology: