Navigation Links
NIH-funded scientists reveal structure of HIV protein key to cell entry
Date:10/31/2013

Using protein engineering and two different cutting-edge structural biology imaging techniques, researchers have developed a detailed picture of the protein largely responsible for enabling HIV to enter human immune cells and cause infection. An in-depth understanding of the atomic structure of the HIV envelope trimeror Env, the three-component protein found on HIV's surfaceis critical to better understanding how HIV gains entry into cells and for creating potential HIV vaccines.

Atomic-resolution imaging of the Env protein has previously been elusive because of the protein's complex, delicate structure. To capture the image, a team of scientists at The Scripps Research Institute and Weill Medical College of Cornell University engineered a more stable version of the protein. Then, in separate studies, using first cryo-electron microscopy and then X-ray crystallography, the researchers were able to reveal the structure of the Env trimer, how it assembles and how it interacts with broadly neutralizing antibodies that target HIV.

Their research, described in two papers published online today in Science Express, received major support from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.


'/>"/>

Contact: NIAID Office of Communications
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert  

Page: 1

Related medicine news :

1. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
2. NIH-funded analysis estimates effective PrEP dosing
3. NIH-funded trial launched to assess experimental TB drug
4. Better stroke care, everywhere: NIH-funded study boosts local hospitals clotbuster use
5. NIH-funded researchers begin trial of Shigella vaccine candidates
6. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
7. Scientists solving the mystery of human consciousness
8. Scientists uncover multiple faces of deadly breast cancer
9. Scientists identify major source of cells defense against oxidative stress
10. Scientists tailor cell surface targeting system to hit organelle ZIP codes
11. Scientists rewrite rulebook on breast cancer in landmark global study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH-funded scientists reveal structure of HIV protein key to cell entry
(Date:7/11/2014)... surgery to repair damage to the anterior cruciate ligament (ACL) ... -- could increase a young athlete,s risk for further injuries, ... patients, aged 8 to 16, who had ACL reconstruction surgery. ... after their injury, 37 had surgery six to 12 weeks ... after their injury. The youngsters who had surgery later ...
(Date:7/11/2014)... CA (PRWEB) July 11, 2014 Ticket ... Bryan Tickets at the Sleep Train Amphitheatre in Wheatland, ... venues that can compare to what the Sleep Train Amphitheatre ... musical events and special attractions over the course of its ... 16th, the Sleep Train Amphitheatre in Wheatland (Sacramento metro area) ...
(Date:7/11/2014)... The “Proteomics Market by Technology (Protein Microarray, Mass ... X-ray Crystallography) - Instruments, Reagents & Services - ... major market drivers, restraints, and opportunities in North ... World (RoW). , The proteomics market has experienced ... due to the increasing need of proteomic outcomes ...
(Date:7/11/2014)... who screened positive for a history of hazardous or ... 50 percent after receiving mobile phone text messages following ... study published online yesterday in Annals of Emergency ... Young Adult Emergency Department Patients: A Randomized Clinical Trial ... 50,000 adults ages 18 to 24 visit ERs and ...
(Date:7/11/2014)... By Steven Reinberg ... -- Stress, hostility and depression may increase the risk for ... depression seemed to raise the risk of a stroke or ... also found that stress apparently raised stroke or TIA risk ... said. A TIA is a mini-stroke caused by a temporary ...
Breaking Medicine News(10 mins):Health News:Delaying Kid's Knee Surgery Could Be a Bad Play, Study Finds 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 2Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 3Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 4Health News:Text message medicine: Texts from the ER can reduce binge drinking 2Health News:Stress, Depression May Boost Stroke Risk, Study Finds 2Health News:Stress, Depression May Boost Stroke Risk, Study Finds 3
... SCHAUMBURG, Ill., May 12 For the estimated ... important fashion accessory,that many women wear, and change, daily. ... more than they bargained for when purchasing,inexpensive earrings. Nickel ... on the earlobes and repeated exposure can make treatment,difficult., ...
... investigation after efforts uncover ... system abuse, ... New York State in 2007. With so many recipients and,providers involved, the ... fraud, waste, and abuse., Over the last two years, Salient Corporation, ...
... for event -, MCLEAN, Va., May 12 ... more effective than real, live dogs or cats ... other aging-related,illnesses?, Come find out Monday, June ... Community (VHRC) in McLean, Va., hosts an industry ...
... its,Distinguished Americans series, the U.S. Postal Service released ... Edward Livingston Trudeau (1848-1915), the,founder and first president ... of Tuberculosis, the precursor to the American Lung ... treating tuberculosis, a,highly infectious disease that at one ...
... Indoor Air Professionals advises consumers on indoor air quality, ... Asthma Awareness Month,according the Environmental Protection Agency (EPA), and ... consumers on the,importance of clean indoor air in relation ... nearly 2 million Americans to the emergency,room in the ...
... earn both national, ... state kudos, SOUTHFIELD, Mich., May 12 ... Care Network of,Michigan., BCN is one of 20 companies worldwide receiving the ... the second year,in a row BCN has earned the annual award. On May ...
Cached Medicine News:Health News:Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel 2Health News:Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel 3Health News:Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel 4Health News:Salient Corporation's Performance Management Solution Helps NY State Counties Identify Medicaid Fraud, Waste, and Abuse 2Health News:Paro, the World's Only Robotic Baby Harp Seal - Designed Specifically for Therapy - to be Focus of Industry Event at Vinson Hall Retirement Community in McLean, Va., June 2 2Health News:American Lung Association Founder Honored With New U.S. Postage Stamp 2Health News:Asthma Awareness Month Spawns Healthy Advice 2Health News:Blue Care Network of Michigan Named a Great Workplace by Gallup, MBPA 2Health News:Blue Care Network of Michigan Named a Great Workplace by Gallup, MBPA 3
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon Solution, ... advanced memory and analog IC solutions, today announced that ... July 24, 2014, at 7:00 a.m. Pacific Time (10:00 ... for the fiscal 2014 third quarter ended June 30, ... telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time on ...
(Date:7/10/2014)... , July 10, 2014  Valeant Pharmaceuticals International, Inc. ... announced it has completed the sale to Galderma of ... owned or held by Valeant for $1.4 billion in ... S.A, which recently completed its acquisition of Galderma. ... of our products to a company that is firmly ...
(Date:7/10/2014)... WOONSOCKET, R.I. , July 10, 2014 CVS ... its board of directors has approved a quarterly dividend of ... The dividend is payable on August 1, 2014, to holders ... Caremark CVS Caremark is dedicated to helping ... integrated pharmacy company in the United States ...
Breaking Medicine Technology:
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... used in the ARED study, as well ... which suggested no AMD disease progression in ... period. Macula Complete also contains efficacious amounts ... support the mitochondria, as well as to ...
... MacularProtect delivers levels of ... vision and macular health in ... by The National Eye Institute. ... of lutein, an antioxidant found ...
... is a scientifically advanced nutritional formulation ... and full body health. MacularProtect Complete ... trial and other advanced research. It ... provides a broad foundation of antioxidants, ...
Medicine Products: