Navigation Links
NIH-funded scientists reveal structure of HIV protein key to cell entry
Date:10/31/2013

Using protein engineering and two different cutting-edge structural biology imaging techniques, researchers have developed a detailed picture of the protein largely responsible for enabling HIV to enter human immune cells and cause infection. An in-depth understanding of the atomic structure of the HIV envelope trimeror Env, the three-component protein found on HIV's surfaceis critical to better understanding how HIV gains entry into cells and for creating potential HIV vaccines.

Atomic-resolution imaging of the Env protein has previously been elusive because of the protein's complex, delicate structure. To capture the image, a team of scientists at The Scripps Research Institute and Weill Medical College of Cornell University engineered a more stable version of the protein. Then, in separate studies, using first cryo-electron microscopy and then X-ray crystallography, the researchers were able to reveal the structure of the Env trimer, how it assembles and how it interacts with broadly neutralizing antibodies that target HIV.

Their research, described in two papers published online today in Science Express, received major support from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.


'/>"/>

Contact: NIAID Office of Communications
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert  

Page: 1

Related medicine news :

1. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
2. NIH-funded analysis estimates effective PrEP dosing
3. NIH-funded trial launched to assess experimental TB drug
4. Better stroke care, everywhere: NIH-funded study boosts local hospitals clotbuster use
5. NIH-funded researchers begin trial of Shigella vaccine candidates
6. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
7. Scientists solving the mystery of human consciousness
8. Scientists uncover multiple faces of deadly breast cancer
9. Scientists identify major source of cells defense against oxidative stress
10. Scientists tailor cell surface targeting system to hit organelle ZIP codes
11. Scientists rewrite rulebook on breast cancer in landmark global study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH-funded scientists reveal structure of HIV protein key to cell entry
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join ... wage raise to $12 an hour by 2020 and then adjusting it yearly to increase ... of the minimum wage, assure the wage floor does not erode again, and make future ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
Breaking Medicine Technology: