Navigation Links
NIH-funded scientists reveal structure of HIV protein key to cell entry
Date:10/31/2013

Using protein engineering and two different cutting-edge structural biology imaging techniques, researchers have developed a detailed picture of the protein largely responsible for enabling HIV to enter human immune cells and cause infection. An in-depth understanding of the atomic structure of the HIV envelope trimeror Env, the three-component protein found on HIV's surfaceis critical to better understanding how HIV gains entry into cells and for creating potential HIV vaccines.

Atomic-resolution imaging of the Env protein has previously been elusive because of the protein's complex, delicate structure. To capture the image, a team of scientists at The Scripps Research Institute and Weill Medical College of Cornell University engineered a more stable version of the protein. Then, in separate studies, using first cryo-electron microscopy and then X-ray crystallography, the researchers were able to reveal the structure of the Env trimer, how it assembles and how it interacts with broadly neutralizing antibodies that target HIV.

Their research, described in two papers published online today in Science Express, received major support from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.


'/>"/>

Contact: NIAID Office of Communications
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert  

Page: 1

Related medicine news :

1. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
2. NIH-funded analysis estimates effective PrEP dosing
3. NIH-funded trial launched to assess experimental TB drug
4. Better stroke care, everywhere: NIH-funded study boosts local hospitals clotbuster use
5. NIH-funded researchers begin trial of Shigella vaccine candidates
6. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
7. Scientists solving the mystery of human consciousness
8. Scientists uncover multiple faces of deadly breast cancer
9. Scientists identify major source of cells defense against oxidative stress
10. Scientists tailor cell surface targeting system to hit organelle ZIP codes
11. Scientists rewrite rulebook on breast cancer in landmark global study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH-funded scientists reveal structure of HIV protein key to cell entry
(Date:4/23/2014)... pilot study by Massachusetts General Hospital (MGH) investigators may ... treatment for a serious medical problem use of ... caused by the Clostridium difficile ( C. ... online in the journal Clinical Infectious Diseases , ... material from donors unrelated to patients was as successful ...
(Date:4/23/2014)... Moffitt Cancer Center researchers say clinical trials for ... leukemia (AML) are very promising. Patients treated with ... and daunorubicin, are showing better responses than patients ... , "Acute myeloid leukemia is an aggressive ... success, especially in older patients," explained Jeffrey Lancet, ...
(Date:4/23/2014)... researcher is looking to give exercise enthusiasts the extra ... research shows that a cyber buddy can help. , ... Health Journal , is the first to indicate that ... during exercise, a software-generated partner also can be effective. ... real can still motivate people to give greater effort ...
(Date:4/23/2014)... - Purdue University researchers have developed a way to ... by using tiny gold particles with tails of synthetic ... agricultural and biological engineering, used gold nanoparticles to target ... BRCA1 messenger RNA splice variants, which can indicate the ... these mRNA splice variants in a cell can be ...
(Date:4/23/2014)... the gastro-intestinal tract has long been considered to be ... Sahlgrenska Academy have used refined microscopic techniques that indicate ... of the gastro-intestinal tract is only as large as ... The digestive tract, which passes from the mouth through ... length of about 5 meters in a normal adult, ...
Breaking Medicine News(10 mins):Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 3Health News:Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia 2Health News:Cyber buddy is better than 'no buddy' 2Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2Health News:The surface area of the digestive tract 'only' as large as a studio apartment 2
... remain stableWASHINGTON, Jan. 6 Karen Ignagni, President and CEO ... data released by CMS today showing that health spending in ... decade at 6.1 percent in 2007. According to the ... 2007, the same rate as in 2006, but much lower ...
... MAQUET Inc., a subsidiary of the Swedish-based ... largest surgical equipment companies in the world, has ... installation of its advanced, prefabricated VARIOP operating ... enables hospitals and surgical centers to reconfigure spaces ...
... University of California, San Francisco has received a $7.5 ... to address the shortage of healthcare workers in Tanzania. ... UCSF Global Health Sciences and the Muhimbili University of ... and document strategies to enable MUHAS and other African ...
... 6 For veterans struggling financially due to a job ... offers an assortment of programs that can relieve the costs ... "With the downturn in the economy, VA recognizes that many ... Dr. James B. Peake. "Therefore, it is important that eligible ...
... can cut down on pounds in middle age, study says ... less. , While it may sound painfully obvious, nutrition experts ... weight loss, because the practice can sometimes boomerang, triggering binge ... eating less can pay big dividends, particularly as you age. ...
... survey recently conducted by the Society of Corporate Compliance ... (HCCA) reveals that the declining economy may be increasing ... In addition, this increased risk is occurring at ... expected to at best hold steady, if not decline.The ...
Cached Medicine News:Health News:AHIP Statement on National Health Expenditure Data 2Health News:MAQUET opens North America's first VARIOP prefabricated operating suite system 2Health News:UCSF-Tanzania get $7.5M from Gates Foundation for partnership to train African health workers 2Health News:It Pays to Eat Less as You Age 2Health News:Legal and Ethical Violations Risks Seen Rising, But Not Resources to Control the Risk 2Health News:Legal and Ethical Violations Risks Seen Rising, But Not Resources to Control the Risk 3
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
(Date:1/15/2014)... LOUISVILLE, Ky. , Jan. 15, 2014  Manufacturers, ... technologies must be able to protect their most ... (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because ... Industry, it steadfastly remains one of the most ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Intellectual Property Insurance for Medical-related Products and Services 2
... Nov. 10, 2011 The Medical Oncology Association ... Solutions recently signed an agreement to work together ... the quality and costs of cancer care in ... provides clinical, reimbursement and distribution services to help ...
... DENVER, Nov. 10, 2011 The American Society of Bariatric ... Bubba Smith.  Our condolences go out to his family, friends ... the medication phentermine was a contributing factor to his death ... using such medications as prescribed. While the ...
Cached Medicine Technology:Medical Oncology Association of Southern California, Cardinal Health Specialty Solutions Collaborate With Payors to Improve Quality, Costs, Accessibility of Cancer Care 2Medical Oncology Association of Southern California, Cardinal Health Specialty Solutions Collaborate With Payors to Improve Quality, Costs, Accessibility of Cancer Care 3Physicians Who Treat Obesity Respond to the News of Bubba Smith's Overdose 2
... for use with GIA DST ... with Titanium Staples)., ,The ... and the SGIA™ Knifeless Stapler ... pediatric and thoracic surgical procedures ...
The Reusable Purse String Clamp is intended for use in the mechanical construction of a purse string suture. The clamp can be used on any part of the gastrointestinal tract except the esophagus....
... Device for use with VALTRAC™ ... Ring)., ,The Purstring™ Device ... and esophageal surgery for the ... and is intended for use ...
... to create an automatic purse-string with ... 45 disposable instrument has application in ... surgery for temporary and permanent purse-string ... disposable instrument has application in intestinal, ...
Medicine Products: