Navigation Links
NIH-funded scientists identify potential malaria drug candidates
Date:11/17/2011

Researchers have discovered a group of chemical compounds that might one day be developed into drugs that can treat malaria infection in both the liver and the bloodstream. The study, which appears in the Nov. 18 issue of Science, was led by Elizabeth A. Winzeler, Ph.D., of the Scripps Research Institute in La Jolla, Calif., and was partially funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Caused by four related parasites in the genus Plasmodium, malaria is transmitted to humans via the bite of an infected mosquito. Once the bite occurs, the parasites travel to the liver, where they usually multiply rapidly for about a week without causing symptoms. Symptoms begin when the parasites spread from the liver to the rest of the body through the bloodstream. However, the parasites can lay dormant in the liver for periods ranging from several months to years before an infected person demonstrates symptoms.

Most of the malaria drugs currently in development target the symptomatic, blood stage of infection. To help achieve malaria eradication, however, a drug would ideally treat infection during both the liver and blood stages. Currently, the World Health Organization recommends only one treatment, primaquine, for the initial, liver stage of certain types of malaria infection; however, primaquine and related drugs can cause a dangerous blood disorder among patients with a genetic condition that is common in malaria-endemic regions of the world. Additionally, drug resistance has been reported, which amplifies the need to find new treatment alternatives.

By screening more than 4,000 chemical compounds that had previously shown activity against blood-stage Plasmodium, the investigators searched for a compound that would also inhibit liver-stage parasites and whose protein structure would allow the modification necessary for future drug development. They found that a group of th
'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH-funded scientists find 2009 H1N1 pandemic influenza vaccine protects mice from 1918 flu virus
2. University of Mississippi Medical Center to lead in nationwide NIH-funded Alzheimers study
3. NIH-funded study finds early HAART during TB treatment boosts survival rate in co-infected people
4. In NIH-funded study, researchers uncover step in brain events leading up to addiction
5. NIH-funded study uses new technology to peek deep into the brain
6. NIH-funded study finds new possible risk factor of heart disease
7. NIH-funded researchers find new ways to confuse blood-seeking mosquitoes
8. Traumatic brain injury: NIH-funded researchers will assess biomarkers for diagnosis and treatment
9. NIH-funded research points to potential therapy for tumor-associated epilepsy
10. NIH-funded twin study finds occupational chemical exposure may be linked to Parkinsons risk
11. Scientists Pinpoint Area of Brain That Fears Losing Money
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... 160 years of neuroanatomy on its head. , Myelin, ... for the fast transmission of impulses along the axons ... according to a new work lead by Professor Paola ... the University,s Department of Stem Cell and Regenerative Biology, ... of Molecular and Cellular Biology. , "Myelin is a ...
(Date:4/18/2014)... Simon Fraser University psychologists have made a brain-related ... of attention-deficit disorders. , This discovery opens up ... hinder or suppress a specific brain activity that ... distraction. , The Journal of Neuroscience ... by John McDonald, an associate professor of psychology ...
(Date:4/17/2014)... inflammation in benign prostate tissue was associated with ... was found even in those with low prostate-specific ... in Cancer Epidemiology, Biomarkers & Prevention , ... Research. , An analysis of prostate tissue biopsies ... of the Prostate Cancer Prevention Trial (PCPT) found ...
(Date:4/17/2014)... Ill. One of the most popular vaccine brands ... And doctors may be overlooking some cost factors when ... a more expensive option, according to a new study ... vaccines to administer can be driven by numerous factors," ... and a professor of computer science and of mathematics ...
(Date:4/17/2014)... 2014) Two recent papers by a University ... may help scientists develop treatments or vaccines for ... encephalitis and other disease-causing flaviviruses. , Jeffrey S. ... genetics at the School of Medicine and an ... Institute, and colleagues recently published articles in the ...
Breaking Medicine News(10 mins):Health News:Finding turns neuroanatomy on its head 2Health News:Finding turns neuroanatomy on its head 3Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:Study recalculates costs of combination vaccines 2Health News:CU researchers discover target for treating dengue fever 2
... Drills and Anesthesia are the instruments dentists’ swear by, what ... to drill// a tooth to treat decay? While you can ... early man could have tapped, researchers have dug up the ... flint head served the purpose of a drill. ...
... one of the world’s poorest country, more than a month ... near its southern border with Nigeria. ,The semi-desert former ... areas on February 28, the day after an outbreak of ... as it lacked the resources to do the job. ...
... administering noxious substance to the patient in the hospital. The woman ... to give lethal doses of drugs to the patient. ... is a member of medical staff but not a qualified nurse. ... bail to return on Wednesday, 17 May. ,The woman, ...
... Tropical cyclone Glenda has increased the spread of the ... Western Australian regions, Kimberley and Pilbara. ,The ... that causes Murray Valley encephalitis (MVE). The cyclone Glenda ... mosquito breeding grounds. ,The Department of Health ...
... According to a recent Florida State University study, hospitals ... in IT// for all hospital operations. ,According ... hospitals, Manatee Memorial and Lakewood Ranch Medical Centre, have ... last few years. He said that, the hospitals are ...
... the medicine metformin is taken once daily it is safe ... words of co-author Dr. Bret Berner, "With this extended-release formula, ... day. The new formulation, which goes by the brand name ... ,Dr. Bret Berner is chief scientific officer and vice ...
Cached Medicine News:Health News:Delayed Start By Niger On Culling Of Poultry 2Health News:Delayed Start By Niger On Culling Of Poultry 3Health News:Technology Can Help Fight Health Care Costs 2Health News:Technology Can Help Fight Health Care Costs 3
(Date:1/14/2014)... /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System - a ... to place and insert the screw accurately - offers ... ligament) repair or reconstruction as it holds the bones ... http://photos.prnewswire.com/prnh/20140114/MN45636 ) The SLIC Screw ...
(Date:1/14/2014)... CLEVELAND , Jan. 14, 2014 NineSigma ... will hold its Innovation Leadership Summit , May ... in Cleveland Ohio . ... innovators and organizations committed to breakthrough achievements through open ...
(Date:1/14/2014)... , Jan. 14, 2014   Evidera , a ... announced that the Center for Drug Evaluation and Research ... first draft qualification guidance document for a patient-reported outcome ... of Chronic Pulmonary Disease Tool [EXACT] for Measurement of ...
Breaking Medicine Technology:Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 2Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 3Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 4
... June 2 Today In the Face of ... help pain management advocates expand their outreach efforts through popular ... to social media applications, such as Facebook, and walks users ... communication vehicles. Topics include "An Overview of Social Media," "Advocacy ...
... , JERUSALEM , June ... of oral drug delivery systems, announced,today that its subsidiary Oramed ... Ltd. ("Laser Detect"), an Israeli company listed on,the Tel Aviv ... be,called Entera Bio Ltd. ("Entera"). Under the terms of the ...
Cached Medicine Technology:In the Face of Pain® Offers Social Media 101 for Pain Management Advocates 2Oramed Pharmaceuticals Forms Joint Venture - Launches Entera Bio Ltd. 2Oramed Pharmaceuticals Forms Joint Venture - Launches Entera Bio Ltd. 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: