Navigation Links
NIH-funded researchers use antibody treatment to protect humanized mice from HIV
Date:2/11/2014

NIH-funded scientists have shown that boosting the production of certain broadly neutralizing antibodies can protect humanized mice from both intravenous and vaginal infection with HIV. Humanized mice have immune systems genetically modified to resemble those of humans, making it possible for them to become HIV-infected.

Led by David Baltimore, Ph.D., of the California Institute of Technology, the investigators inserted the genes encoding the NIH-discovered broadly HIV neutralizing antibody VRC01 into a vector, a virus that infects mice but does not cause disease. In a unique technique known as vectored immunoprophylaxis (VIP), the researchers infected laboratory mice with this altered virus, enabling certain of their cells to produce the antibodies for extended periods. To test the applicability of this approach to human infections, the researchers used a novel method of repeatedly exposing these mice to low doses of HIV in a manner that mimics human sexual intercourse. In two separate experiments, the investigators assessed protection from infection with two strains of HIV: a standard laboratory strain as well as one that is commonly transmitted among humans.

Two of the 10 mice expressing VRC01 antibodies became infected with the laboratory strain of HIV after 13 to 15 exposures to the virus. In contrast, all nine mice without the antibodies were infected with HIV within six exposures. In the second experiment, researchers used a modified form of the VRC01 antibody, known as VRC07, and challenged the mice with an HIV strain known to be heterosexually transmitted among people. The mice expressing the VRC07 antibody were completely resistant to infection during repeated intravaginal challenge. Taken together, these results indicate that VIP can protect mice from infection with strains of HIV that cause human disease and suggest that a similar strategy could be developed to reduce transmission in people, the authors write.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. NIH-funded scientists reveal structure of HIV protein key to cell entry
2. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
3. NIH-funded researchers begin trial of Shigella vaccine candidates
4. Better stroke care, everywhere: NIH-funded study boosts local hospitals clotbuster use
5. NIH-funded trial launched to assess experimental TB drug
6. NIH-funded analysis estimates effective PrEP dosing
7. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
8. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
9. Researchers discover new hormone receptors to target when treating breast cancer
10. Kessler Foundation MS researchers study predictors of employment status
11. RI Hospital researchers identify components in C. diff that may lead to better treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2019)... ... October 14, 2019 , ... Khalieghya Dandie-Evans, a liver transplant ... atop the Donate Life Rose Parade® float in the 131st Rose Parade® on New ... donation across Northern California and Northern Nevada, the organization’s service area. , Khalieghya, 17, ...
(Date:10/15/2019)... (PRWEB) , ... October 15, 2019 , ... Nashville Fertility ... be the latest fertility doctor to join the practice. In addition to treating general ... syndrome (PCOS). , The team at NFC looks forward to Dr. Van Heertum joining ...
(Date:10/10/2019)... ... October 10, 2019 , ... ... and information technology (IT) services for the healthcare industry, has completed the first ... Authority (PHA) of the Commonwealth of The Bahamas towards a fully integrated health ...
(Date:10/8/2019)... ... ... SoCal Adolescent Wellness announces the opening of a second location in Lake ... better serve the families in Orange County," said Becca Moody, CEO of SoCal Adolescent ... this pre-intervention program has on the lives of the adolescents and families we work ...
(Date:10/8/2019)... ... 08, 2019 , ... As a world-renowned expert using intravital ... with the University of Maryland Department of Veterinary Medicine, continues to make new ... and his lab have discovered a new pathway by which liver macrophages called ...
Breaking Medicine News(10 mins):
(Date:10/17/2019)... ... October 17, 2019 , ... Mount Sinai researchers have identified ... who would otherwise have no treatment options, according to a study published in ... and aggressive pediatric nervous system tumors and generally has a poor prognosis, particularly ...
(Date:10/17/2019)... ... , ... The findings of a new study on lung injury associated with ... by toxic chemicals rather than the inhalation of oily substances. , The study, ... Report of Eight Cases ,” by Sanjay Mukhopadhyay, MD, FASCP, et al., was published ...
(Date:10/15/2019)... ... ... An Alabama jury has returned a $9 million verdict for the family ... Lee County. , In December of 2014, Hope Johnson visited Auburn Urgent Care after ... days earlier with similar, but milder complaints. On that first visit, she was examined ...
Breaking Medicine Technology: