Navigation Links
NIH-funded researchers use antibody treatment to protect humanized mice from HIV
Date:2/11/2014

NIH-funded scientists have shown that boosting the production of certain broadly neutralizing antibodies can protect humanized mice from both intravenous and vaginal infection with HIV. Humanized mice have immune systems genetically modified to resemble those of humans, making it possible for them to become HIV-infected.

Led by David Baltimore, Ph.D., of the California Institute of Technology, the investigators inserted the genes encoding the NIH-discovered broadly HIV neutralizing antibody VRC01 into a vector, a virus that infects mice but does not cause disease. In a unique technique known as vectored immunoprophylaxis (VIP), the researchers infected laboratory mice with this altered virus, enabling certain of their cells to produce the antibodies for extended periods. To test the applicability of this approach to human infections, the researchers used a novel method of repeatedly exposing these mice to low doses of HIV in a manner that mimics human sexual intercourse. In two separate experiments, the investigators assessed protection from infection with two strains of HIV: a standard laboratory strain as well as one that is commonly transmitted among humans.

Two of the 10 mice expressing VRC01 antibodies became infected with the laboratory strain of HIV after 13 to 15 exposures to the virus. In contrast, all nine mice without the antibodies were infected with HIV within six exposures. In the second experiment, researchers used a modified form of the VRC01 antibody, known as VRC07, and challenged the mice with an HIV strain known to be heterosexually transmitted among people. The mice expressing the VRC07 antibody were completely resistant to infection during repeated intravaginal challenge. Taken together, these results indicate that VIP can protect mice from infection with strains of HIV that cause human disease and suggest that a similar strategy could be developed to reduce transmission in people, the authors write.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. NIH-funded scientists reveal structure of HIV protein key to cell entry
2. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
3. NIH-funded researchers begin trial of Shigella vaccine candidates
4. Better stroke care, everywhere: NIH-funded study boosts local hospitals clotbuster use
5. NIH-funded trial launched to assess experimental TB drug
6. NIH-funded analysis estimates effective PrEP dosing
7. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
8. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
9. Researchers discover new hormone receptors to target when treating breast cancer
10. Kessler Foundation MS researchers study predictors of employment status
11. RI Hospital researchers identify components in C. diff that may lead to better treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ... California, will be included in the 2016 “Guide to America’s Top Plastic Surgeons” ... on the amalgamation of their education, experience, and professional associations. , One ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... veterinarian diagnostic imaging systems and the first company to offer robotic ... a Heart at their tradeshow booth # 941 for the American Association of ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... journeys, announced today that it has raised $6.0 million in an initial round ... Clarify Health’s conviction that patients and their caregivers can receive far better care ...
(Date:11/30/2016)... ... November 30, 2016 , ... The ... been designated as a Cigna Infertility Center of Excellence. The Cigna Center of ... , “It’s an honor to be designated a Cigna Infertility Center of Excellence," ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... health treatment has announced the opening of a new residential mental health treatment ... with mental health issues such as severe anxiety, depression, bi-polar disorder, and other ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , Dec. 2, 2016 The U.S. ... for Jardiance (empagliflozin) to reduce the risk of cardiovascular ... and cardiovascular disease. "Cardiovascular disease is ... 2 diabetes mellitus," said Jean-Marc Guettier , M.D., ... Products in FDA,s Center for Drug Evaluation and Research. ...
(Date:12/2/2016)... December 2, 2016 Persistence Market ... market in its upcoming report titled, "Global Market Study on Cardiac ... CAGR of -1.4% between 2016 and 2024". The global cardiac ... 2015 and this is likely to decline to US$ ... global cardiac pacemaker market is anticipated to exhibit a ...
(Date:12/2/2016)... 2016 According to the latest market ... on Automated Endoscope Reprocessors: Single Basin Automated Endoscope Reprocessors Product ... 2016 and 2024 " the global automated endoscope reprocessors market was valued at ... at a CAGR of 7.2% during an eight-year forecast period ... by 2024. ...
Breaking Medicine Technology: