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NIH expands study to better understand kidney disease progression
Date:7/29/2013

e better kidney function or less severe disease -- known as mild to moderate CKD -- than the original study participants. They will also be screened for protein in the urine, a sign of kidney damage. Most of the U.S. population with CKD has mild to moderate disease.

"By more closely studying a group with better kidney function, we can try to learn how to prevent kidney disease," Star said. "We want to better understand the risk factors for worsening of kidney function to design new strategies for treatment of CKD and its complications."

Lastly, although the CRIC study investigators carefully studied the association of cardiovascular disease with CKD, recent analyses revealed that many patients were hospitalized frequently for respiratory and digestive illnesses. This finding led study investigators to plan to collect more information on the impact of CKD on hospitalizations, according to Star. "Together with expanding the existing study population to include additional older patients and earlier stages of CKD, this fresh approach amounts to a regeneration of the CRIC study that will map out a whole new way to evaluate the impact of CKD," he said. "Although the relationship between CKD and cardiovascular disease is still a major focus, since it's the big killer among CKD patients, the CRIC study will examine more closely these other related illnesses that impact so significantly on patients' overall functioning and health."

Feldman added that the study will continue, in accordance with applicable data privacy laws and policies, to send study data and specimens from all participants to the Central NIDDK Repositories. All data and specimens are made available to a wider research community to expand the usefulness of the study.

An estimated 20 million or more American adults have CKD, and over 400,000 people in the United States and 2 million worldwide depend on dialysis to treat kidney failure. CKD costs the nation $44 billion pe
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Contact: Bill Polglase
NIDDKMedia@mail.nih.gov
301-496-3583
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Source:Eurekalert

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