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NIH awards WSU researcher $1.7 million to study non-alcoholic fatty liver disease
Date:7/28/2011

es NAFLD.

"This project will not only define the molecular basis by which a novel stress-sensing protein factor regulates lipid metabolism, it will also be significant for designing new strategies to prevent and treat human non-alcoholic fatty liver disease and its associated metabolic syndromes," said Zhang.

The first step in Zhang's investigation is to identify the mechanism that causes fatty acids to activate CREBH. He will then decipher the molecular code that allows CREBH to control the amount of fatty acids in the liver. His final step will be to understand the involvement of CREBH in taking fatty liver disease to its more severe state, steatohepatitis.

Zhang is collaborating with School of Medicine colleagues Leonard Lipovich, Ph.D., assistant professor of molecular medicine and genetics and of and neurology; Todd Leff, Ph.D., associate professor of pathology; Bruce Berkowitz, Ph.D., professor of anatomy and director of WSU's Small Animal MRI Facility. Zhang is also working with Stephen Duncan, D.Phil., Marcus Professor of Human and Molecular Genetics at the Medical College of Wisconsin; and Maria Isabel Fiel, M.D., professor of pathology at the Mount Sinai School of Medicine in New York City.


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Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

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