Navigation Links
NIH awards WSU researcher $1.39M to study chromatin's role in cell division
Date:8/16/2011

DETROIT The National Institute of General Medical Sciences of the National Institutes of Health recently awarded Lori A. Pile, Ph.D., assistant professor of molecular cell biology in Wayne State University's College of Liberal Arts and Sciences, $1.39 million to research how the alteration of chromatin regulates cellular division and growth. The study is intended to support the development of cancer treatments currently undergoing clinical trials.

Chromatin is a DNA-protein structure that resembles a long DNA "string" wrapped around protein "beads." When certain molecules, called chromatin modifiers, react with the protein beads, the entire chromatin structure either decompresses or coils up tightly. "Chromatin modification depends on whether the proteins were acetylated or deacetylated in other words, what kind of modifier reacted with the protein," said Pile.

There are two main types of chromatin modifiers. Histone acetyltransferases (HATs) acetylate the proteins, loosening the chromatin structure. Histone deacetylases (HDACs) deacetylate and tighten DNA's grip on the proteins. A correct balance of action of these chromatin modifiers is necessary for normal cell division. Both activities are required for cells to multiply. But when the balance tips in favor of the deacetylation step, cells can multiply too much, Pile said, and cancer is often the culprit.

That is why deacetylation is being targeted by researchers looking for a way to treat patients with cancer. Yet the exact role of HDACs and deacetylation requires more in-depth exploration.

"While a number of chromatin modifiers are currently being tested as anti-cancer agents in clinical trials, the molecular mechanisms behind their cancer-killing properties are not well understood," said Pile. "Our study is anticipated to clarify these mechanisms and refine the molecular tools designed to target cancer."

These "molecular tools" are histone deacetylase inhibitors, or HDIs. To refine HDIs, Pile will uncover the mechanisms of the target, HDAC chromatin modifiers. She will test a particular HDAC called Swi-independent SIN3 and determine whether SIN3 does, in fact, regulate cell growth and multiplication and, if so, how it affects deacetylation and gene repression.

"Inhibiting HDACs, the agents that fuel unregulated cell division, is anticipated to be an effective approach to preventing cancer progression," said Pile.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. Mental Health America Encourages Journalists, Media Professionals to Submit Entries for 2010 Media Awards
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. International Diabetes Federation awards $2 million to 9 global diabetes research projects
4. Highmark Foundation Awards $120,000 to the American Heart Association
5. Diane von Furstenberg Establishes The DVF Awards to Recognize Outstanding Women Leaders
6. Siemens Awards for Advanced Placement Honor Top U.S. Science and Math Students and Teachers
7. Awards Strengthen Stonhard's Reputation for High-Performing Floors in the World's Most Prominent Pharmaceutical Facilities
8. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
9. AADR awards the 2010 Distinguished Mentoring Award to Irwin D. Mandel
10. AADR awards the 2010 AADR William B. Clark Fellowship to Isabel Gay
11. AADR awards the 2010 Distinguished Scientist Award to John Greenspan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... , ... May 27, 2016 , ... W.S. Badger ... announced today that it has been recognized as one of the best small businesses ... was named as one of nine small businesses providing progressive benefits to new parents ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... ... with Mediaplanet to help educate the many who are unaware of the plight ... to aphasia will run within the “Stroke Awareness” campaign. , The link between ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... in the pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation ... providing proof of successfully certified products, services and staff. , Validation Center is ...
(Date:5/26/2016)... ... May 26, 2016 , ... Intalere, ... members and suppliers for its inaugural Member Conference at the Paris Hotel in ... elevating the operational health of America’s healthcare providers. , The conference was highlighted ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia ... negative impact on long-term patient survival, reports a team of UPMC researchers in ... week in the Journal of Thoracic and Cardiovascular Surgery, provide critical information that ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 According to ... Type (3D, 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic ... User (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast to ... Medical Animation Market for the forecast period of 2016 ... 301.3 Million by 2021 from USD 117.3 Million in ...
(Date:5/25/2016)... 25, 2016 According to market ... Growth and Demand Forecast to 2022 - Industry Insights ... Others)" published by P&S Market Research, the global insulin ... 2015, and it is expected to grow at a ... insulin pump segment is expected to witness the fastest ...
(Date:5/25/2016)... England , May 25, 2016 ... company employing the precision of circulating tumour DNA ... today announces the appointment of Professor Clive ... provide medical leadership across the clinical development programme, ... Inivata,s products help deliver significant improvements in clinical ...
Breaking Medicine Technology: