Navigation Links
NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
Date:7/14/2010

JUPITER, FL, July 14, 2010 For Immediate Release A pair of scientists on the Florida campus of The Scripps Research Institute has been awarded a $2.3 million grant by the National Institutes of Health (NIH) to conduct research relevant to developing new treatments for drug addiction.

Patricia McDonald, an associate scientific director in the Translational Research Institute at Scripps Florida and an assistant professor in the Department of Molecular Therapeutics, and Theodore Kamenecka, an associate scientific director in the Translational Research Institute, are co-principal investigators for the five-year project funded by the NIH's National Institute on Drug Abuse (NIDA).

The research will focus on indentifying compounds that affect the Neurotensin receptor (NTSR1), a receptor that appears to play a significant role in drug addiction because of its ability to alter levels of the neurotransmitter dopamine in the brain.

"Despite almost three decades of work by the pharmaceutical industry and other researchers, there are still few compounds known to act on NTSR1," said McDonald. "This new funding will help us thoroughly explore the interactions between the receptor and its signaling pathways and its impact on dopamine, which helps drive addiction and relapse."

The neurotransmitter dopamine is released when addictive drugs stimulate a reward circuit in the brain. Drug-induced changes in the reward circuit then reinforce the link between the pleasurable experience and the drug, increasing the tendency towards addiction. Blocking the surge of dopamine could protect the brain from these addictive changes, while substantially reducing the risk of relapse.

Kamenecka noted, "Our grant was something special in the sense that the NIH was looking for something very specific new ways to accelerate the search for potential treatments of central nervous system disorders, which is what we expect to deliver. It also provides a good opportunity for Patsy's and my laboratories to collaborate on an important therapeutic area drug addiction is an area with a lot of unmet medical needs."

The scientists said they expect to use a multiple test or assay approach to identify compounds that act on NTSR1, a method both believe will be an improvement over the current single assay approach typically used in the pharmaceutical industry.

"We want to avoid missing any potentially valuable compounds," McDonald noted, "so we plan to cast as wide a net as possible to capture compounds that modulate the receptor through different mechanisms."

If the team identifies compounds of interest, the scientists plan to determine their "functional fingerprint," then work with addiction experts at Scripps Florida, such as Associate Professor Paul Kenny, to help validate the compounds as potential therapeutics for addiction. Their search may ultimately move beyond addiction, however, since NTSR1 and related receptors such as NTSR2 and NTSR3 are also involved in diseases such as Alzheimer's, Parkinson's, and even some cancers.


'/>"/>

Contact: Miko Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Related medicine news :

1. AOSSM presents prestigious research awards at annual meeting
2. Solar Eclipz's Portable Umbrella And Canopy Curtain, Called The ezShade, Wins Coveted Outstanding Product Award From Disney Owned iParenting Media Awards
3. Outstanding high school students receive AGA Foundation 2010 Student Research Fellowship Awards
4. Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators
5. Parkinsons Disease Foundation announces research awards totaling $1.2 million
6. Nominations Wanted for Vascular Disease Foundation President's Awards
7. Dorland Health People Awards Accepting Entries through Friday, June 25, 2010
8. The Jewish Fund Awards Mercy Primary Care Center $100,000 Over Three Years for Chronic Disease Management of Hypertensive Patients
9. ASTRO patient education program recognized by AAA Awards
10. Susan G. Komen for the Cure awards grant to Lombardis V. Craig Jordan
11. Intent.com Launches 30 Days of Intentions and Announces Winners of 2010 Intent Web Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics ... PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... of Morris F. Collen, a pioneer in the field of medical informatics, this prestigious ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... 2017   OrthoAtlanta has been named the official ... Committee (AFHC) for the 2018 College Football Playoff (CFP) National ... Mercedes-Benz Stadium in Atlanta, Georgia . OrthoAtlanta ... In" campaign, participating in many activities leading up to, and ... ...
(Date:9/12/2017)... 12, 2017  Consumer reviews on the independent review site ... number one company for hearing aids, ranking it higher than ... ... by Consumers For Hearing Aids ... is an online store that provides high performance, state-of-the-art, German-engineered hearing ...
(Date:9/9/2017)... , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September ... Washington, D.C. offering free MRI brain scans to the public.Where:  ... will be parked at 501 K Street NW, Washington, D.C.What:BTF brings its ...
Breaking Medicine Technology: